Rheumatoid arthritis , chirwere chemoto chinokanganisa 1.3 kusvika ku5 mamiriyoni evanhu veAmerica, ndicho chikonzero chemuviri wemuviri wechirwere unokonzera martila nemasangano. Chii chaicho chinotanga haywire mumuviri wemuviri wemunhu ane rheumatoid arthritis kukonzera marwadzo nekuparadzwa kunobatanidza nechirwere ichi?
Zvidzidzo zvakaitwa naDr. Julia Ying Wang weBrigham & Women's Hospital muBoston neHarvard Medical School, pamwe chete neshamwari yake Dr. Michael H.
Roehrl yeHarvard, yakataurwa pamusangano wegore negore weAmerican Chemical Society munaAgasti 2002 uye yakabudiswa muPNAS, ichibata mubvunzo iwoyo.
Pamberi pebasa ra Wang neRohrl, tsvakurudzo yeArthritis yeArthritis yakanyanya kuisa peptidi, kana zvidimbu zveprotini. Wang uye Roehrl vakaratidza kuti glycosaminoglycans, kana kuti GAGs, ndizvo zvinokonzera rheumatoid arthritis panzvimbo peprotein.
The GAGs Theory
Glycosaminoglycans inokonzerwa nemaitiro ehydrohydrates inowanika muhutikiti , hutachiona hunobatanidza , hubatanidza mvura, uye ganda. Glycosaminoglycans yakaoma makhahydrates. Hazvivhiringidzika nema carbohydrate, nenyuchi, uye shuga tinodya muzvokudya zvedu.
Zvakarehwa, mazano aWang akatsanangura kuti maune immune system cells, kana antibodies, anotarisa glycosaminoglycans. I-antibodies inosunga kuGAGs, inowedzera muzvibatanidza, uye inotanga marwadzo uye kuputika kunobatanidza rheumatoid arthritis.
Tsvakurudzo
Muchidzidzo che Wang uye Roehrl, mutsva dzakanga dzakapindwa neGAGs.
Mheve dzakagadzirisa zvirwere zvehurmitis-zviratidzo zvakadai, kusanganisira kuvhuvhuta, kupfupa, uye mapfupa.
Glycosaminoglycan antibodies kubvira panguva yakawanikwa muzvinyorwa zverhumatori varthritis varwere. Inofanira kusimbiswa kuti iyi yaiva yekutanga glycosaminoglycan antibodies yakanga yaonekwa mune mhuka kana vanhu.
Vatsvakurudzi vakataura kuti:
- GAG mishonga inogona kukura semagumisiro eubhakitiriya.
- Mazinga akadai eGAG angaguma apo mabhakitiriya anokonzera mishonga inokonzera hutachiona hunogadzirwa uye kusunungura makhahydrates.
- Mabhakitiriya akawanda ane GAG muchitanda chepamusoro. Mu rheumatoid arthritis, masero ezvirwere zvemasununguko anogona kukanganisa zvakananga maGAGs anowanzoitika mumitumbi yomuviri nenzira imwechete yaanokwanisa kutarisa GAG pamusana pevavhiringidzi vebhakitiriya.
Vatsvakurudzi vaitarisira kuti zvimwe zvidzidzo zvingaratidza nzira yekusunga GAG mishonga, zvichiendesa kumishonga matsva kana mishonga ye rheumatoid arthritis. Chidzidzo chakabudiswa muna 2008, muArthritis Research & Therapy , chakajekesa zvakawanda pamusoro peGAGS:
- GAG-specific antibodies haisipo neonates (macheche).
- GAGs iripo zvakakwana mu serum yevakuru.
- GAGs dzakarongerwa seTI2 antigens. B1 B masero anozivikanwa kuti anopindira neTI2 antigens.
Yakaratidzwa zvakare kuti anti-GAG zvinopesana nemasikirini anonzi autoantibodies anowanikwa mune vanhu vane utano. IgM anti-GAG maviri uye mamwe maGG-anti-GAG anowanikwa maitiro akawanikwa akawanikwa akakwidziridzwa mune sera yevarwere vane arthritis rheumatoid. Kunyange zvazvo varwi-anti-GAG vakange varipo mumagetsi e systemic, synovial fluid uye vaikwanisawo kusunga kumatrix extracellular ye hyaline cartilage.
Vanotsvakurudza vanofunga kuti anti-GAG yekushambadzira kwepisitori "inogadziriswa" mu rheumatoid arthritis zvichida yakabatana nekusunungurwa kwekatekete mamolekemu. Zvinofadza, kukwirira kunopesana neGAG mazinga kunobatanidza nehutachiona hwehutachiona hwehutachiwana mu rheumatoid arthritis. Vatsvakurudzi vakagumisa kuti GAGs inogona kushanda sechirwere chekare chinonzi biomarker ye rheumatoid arthritis.
Sources:
Glycosaminoglycans Inogona Kukonzera Chirwere cheRhumatoid Arthritis. Proceedings ye National Academy of Sciences yeUnited States of America. Wang JY naRohrhr MH. Gumiguru 21, 2002.
Natural Autoantibodies Shanda NaGlycosaminoglycans muRheumatoid Arthritis. Bence Gyorgy et al. Arthritis Research & Therapy. 2008.