High Grade Large uye Small Cell Neuroendocrine Tumors yeColon
Kana iwe kana munhu waunoda akaonekwa kuti ane chirwere chinotyisa kana chepamusoro cheurouroendocrine yekoloni kana rectum iwe unogona kunge uchitya uye uchinetseka. Zvirwere zvechisimba zvinopisa neuroendocrine hazvisi zvishoma kudarika mamwe emamwe kenza kanoroni. Mukuwedzera, ivo vanowanzofungidzirwa zvisina kunaka uye zvakakosha kuva vatsigiri venyu kana mune rimwe remavara aya.
Chii chatinoziva nezvekenza iyi, inobatwa sei, uye chii chinonzi chirevo?
Chii Chinonzi Neuroendocrine Tumors?
Zvirwere zveNeuroendocrine zvirume zvinotanga mumasero euroretocrine. Zvinogona kuitika mumakumbo ekudya, mapapu, kana uropi. Muchikamu chekudya chinogona kusanganisira chironda, pancreas, musana muduku, colon, uye rectum.
Mumakoroni uye rectum, tumoramu neuroendocrine inokonzera 2 muzana kana kuti zvishoma zvekodha dzekenza . Zvinosuruvarisa, kusiyana nemamwe mhando dzekenza yekoloni, kufungidzira kusina kuchinja zvakanyanya mumakore achangopfuura nekenza yekenza kuongorora.
Matumbo eEuroendocrine ave achiwedzera, ane kuwedzera kwemazana mashanu kubva muna 1973 kusvikira muna 2004 uye kuwedzera kuwedzera kubvira panguva iyoyo. Hazvina chokwadi kuti nei ichi chiri kuitika panguva ino.
Ane utsinye vs. Mumiriri Mumuviri
Zvironda zveNeuroendocrine zvinotanga kugoverwa kuva zviviri zvakakosha zvikamu zvichienderana nekutsamwa kwemakumbo.
- Kirasi yepamusoro masero masero uye zviduku zvesero seuroendocrine zvinotyisa. Izvi zvinokonzera kukura nokukurumidza uye kupinda mune mamwe maviri
- Zvironda zveCarcinoid zvekoloni zvinonzi zvisinganyengeri. Vanowanzova nekukurumidza kukura nekusanyanya kusvibiswa kudarika masero masero uye maduku masero euroendocrine tumor.
Zvakakosha kuparadzanisa maronda ane utsinye uye asingasviki sezvinoitwa kurapwa kwakanaka uye pamwe nekufananidzira kwakasiyana zvikuru.
Masero Makuru uye Masero Mashoma Madiki
Kirasi yepamusoro, kana zvechisimba, neuroendocrine tumorama inogoverwa kuva huru huru uye zviduku zvemasero esero, izvo zvinopesana zvichienderana nekuonekwa kwemasero pasi pekroscope. Mhando dzose dzekenza dzinofungidzirwa zvikuru "zvisinafferentiated" izvo zvinoreva kuti masero anoonekwa seasati apera kune mamwe masero euroendocrine uye anorarisa zvikuru. Munguva yakapfuura yaifungidzirwa kuti hurukuro dzemasero dzese dzaive dzakajairika, asi chidzidzo che 2016 chakawana kuti 89 muzana yemakumbo aiva maduku masero eurosteocrocrine tumor.
Mune dzimwe nzira, tumakemikari yepamusoro neuroendocrine yakafanana nekenza yemukenza yemapapu, uye kazhinji inobata zvirwere zvakafanana, asi hazvikwanise kubatanidzwa nekusvuta kupfuura zviduku zvekenza dzemapapu uye hazvikwanise kuva nemasitema kumapfupa uye neuropi.
Dzimwe tsvakurudzo dzakaona kuti maturu anowanzoitika kakawanda kune rumwe rutivi rworudyi rwekoloni (kukwira koroni) asi kuongorora kwechangobva kuwanikwa kwakawana kuti nzvimbo yakawanda yezviremara izvi yaiva rectum uye sigmoid colon.
Kenza kenza yeColon haina kutungamirira kukuwedzera kwakanyanya mukufananidzira kwezviremera izvi, kunyange mune imwe dzidzo, 30 muzana yemakumbo yakawanikwa kuti inobatanidza nedenomas .
Ruzhinji rwemakumbo (64 muzana) ndeyeroti 4 kana metastatic panguva yekuongororwa.
Zviratidzo
Zviratidzo zvezvipembenene zveeuroendocrine zvekoloni zvinogona kusanganisira kuchinja mumararamiro, semararha, kurwadziwa kwepamuviri, uye zvose zviripamusoro kana kuderera kweropa rekuyeresa. Sezvo izvi zvipembenene zvinowanzowanikwa mumatanho akazotevera, zviratidzo zvekukura kwekenza zvakadai sekusazvipira kwekurema kwekurema zvinowanzowanikwa.
Kuvimbisa Kuziva Zvakanaka
Kutsvakurudza kunoratidza kuti mhirizhonga ine hutsinye neuroendocrine inowanzotanga kusarudzwa sezviremara zvecarcinoid. Icho chikanganiso chisina kunaka sezvo carcinoid inokura zvishoma uye inowanzopararira.
Kana iwe wakamboudzwa kuti une chirwere checarcinoid, iva nechokwadi chokuti ane ruzivo rwechirwere unobvumirana nekuongorora kwako. Kuita izvi zvinoda kuti iwe ubvunze chiremba wako mibvunzo inokosha:
- Ane chiremba wepachirwere akabatanidzwa mukuverengera kwokupedzisira kwemuviri wangu wepamuviri here?
- Muchengeti wezvirwere ane ruzivo rwekuparadzanisa pakati pemakumbo ane utsinye uye asingasviki neuroendocrine here?
- Ko chiremba wacho anotaura chero upi nechokusava nechokwadi pamusoro pekuongororwa kwangu here?
Kana mhinduro dzacho asiri hongu, hongu, uye kwete (kana chaizvoizvo pedyo neizvozvo), boka rako rezvehutano rine basa rakawanda rokuita risati rakupa iwe tsanangudzo yekujekesa.
Kurapa
Iko haisi ikozvino mishonga inowirirana yezvipembenene zvetsinye neuroendocrine yekoloni uye rectum. Mushonga wacho, zvisinei, unotarisa padanho remuviri. Kana imwe yemakumbo aya inowanikwa mumatanho ekutanga, kuwirirana kwekuvhiya, chirwere chemaawa, uye chemotherapy kunogona kufungwa.
Nokuda kwechikwata chepamusoro-grade grade neuroendocrine tumor, chemotherapy ndiyo kurapa kusarudzwa uye kunogona kukonzera kupona kwenguva refu. Chemotherapy regimens yakafanana neaya inoshandiswa kurapa kenza kemukamu kadiki kadiki , kazhinji inosanganisira zvinodhaka zveplatinum zvakadai sePlatinol (cisplatin) kana Paraplatin (carboplatin.)
Tsvakurudzo dzinosanganisira genomic kufungidzirwa kwezviremara izvi zvinopa tariro kuti, mune ramangwana, inotarisirwa kurapwa inogona kuwanika pakurapa chirwere chacho.
Prognosis
Zvinokanganisa neuroendocrine matumbo zvinowanzoongororwa pane zvidzidzo zvakanyanyisa, mamiriro ezvinhu anowanzokonzera kusagadzikana kwakaipa. Kurapa chete kwakaratidzwa iye zvino kusvika pakuvandudza kupona ndiko chemotherapy.
Panguva yazvino, kupona kwemazuva mashoma (kureba kwenguva inotevera iyo hafu yevanhu yakafa uye hafu ichiri kurarama) ndeyemwedzi 13 kusvika ku15, ine makore maviri ekupona kwema 23 kubva muzana uye kupona kwemakore mashanu kwemasere masere percent.
Kutsungirira
Kuongororwa kuti une kemukari yakakura yeurouroendocrine haisi kungotyisa chete, asi inogona kuva yakavhiringidza sezvo mamiriro acho asina kufanana. Kutaura kwechirwere ichi, nhamo hachina kuchinjwa zvakanyanya mumakore achangobva kupfuura, asi kufambira mberi mune zvokurapa, zvakadai sekuuya kwezvinorapwa zvirwere uye immunotherapy , zvinopa tariro kuti mushonga mutsva uchave uripo mune ramangwana idzva.
Taura nachiremba wako pamusoro pekushandiswa kwekliniki miedzo iyo iri kuongorora idzi mishonga. Iva iwe mupepeti wako mukuchengetedza kwekenza yako uye bvunza mibvunzo. Kumbira rubatsiro kubva kune vaunoda uye uvabvumirire kukubatsira. Mukuwedzera, vanhu vazhinji vanozviona zvichibatsira kuti vasvike kune vekusigirwa munharaunda dzemunharaunda. Kunyange hutsinye hwemapurisa neuroendocrine husingawanzoitiki uye hazvigoneki kuti une boka rekutsigira iri mumunharaunda yako, internet inokubvumira kupinda mukutarisana nevamwe vanotarisana nechinhu chimwe chete iwe uri munyika yose.
Sources:
Conte, B., George, B., Overman, M. et al. High-Grade Neuroendocrine Colorectal Carcinomas: A Retrospective Study of 100 Varwere. Clinical Colorectal Cancer . 2016. 15 (2): e1-7.
Hammond, W., Crozier, J., Nakhleh, R., naK. Mody. Genomic Profiling ye High-Grade Large-Cell Neuroendocrine Carcinoma yeColon. Nhoroondo yeOkudya Kwemazino . 2016. 7 (2): E22-4.
Shafgat, J., Ali, S., Salhab, M, uye A. Oszewski. Kuponeswa kwevarwere neNeuroendocrine Carcinoma yeColon uye Rectum: A-Based-Based Analysis. Zvirwere zveColon neRectum . 2015. 58 (3): 294-303.
Smith, J., Reidy, D., Goodman, K., Shia, J., naG. Nash. Kudzokorora Kudzokorora kwe 126 High-Grade Neuroendocrine Carcinomas yeColon uye Rectum. Annals of Oncology Surgery . 2014. 21 (9): 2956-62.