Kushandisa, Migumisiro Yechipfuva, Kuyera, uye Kushandisa Methotrexate Mukubata
Chii Chinonzi Methotrexate?
Methotrexate ndeyekirasi yemishonga inozivikanwa seine antineoplastics. Antineoplastics inokanganisa maitiro emasikirwo emuviri, zvakadai seDNA production uye cell division. Vanobatsira mukurapa kwekenza, nokuti vacharamba kudzivirira kenza yemasera kubva kukura. Methotrexate inogonawo kupiwa kurapa akylosing spondylitis, rheumatoid arthritis, psoriasis, uye Crohn's disease
Methotrexate Inotorwa Sei?
Methotrexate inofanira kutorwa sezvakataurwa nachiremba. Chimiro chepanyama chichagadzirisa muyero kune zvinodiwa zveumwe neumwe murwere. Methotrexate inogona kupiwa sehwendefa, infusion kana injection. Kana ikatorwa kamwechete pavhiki, zvakanakisisa kuitora pazuva rimwechete vhiki imwe neimwe.
Nei Nei Methotrexate Inorondedzerwa?
Nemhaka yokuti methotrexate inodzivirira sero metabolism, inorayirwa kune mamiriro ezvinhu asina kujaira masero ekukura ichinetso, zvakadai se psoriasis kana kenza. Methotrexate inowanikwawo inobatsira pakurapa dzimwe mhaka dzeCrohn's disease uye rheumatoid arthritis . Methotrexate yakave ishandiswawo kukurudzira kusununguka kwepamuviri muEctopic pregnancy.
Ndiani Asingafaniri Kutora Methotrexate?
Taurira chiremba wako kana iwe wakambove nechimwe chezvinhu zvinotevera:
- Iye zvino ari pamuviri
- Chirwere chepoyo
- Chirwere chirwere kana chirwere cheprhosis
- Chirwere chakaremara kana fibrosis
- Neurologic disease
- Zvirwere zvekare
Chii Chinonzi Maitiro Akashata?
Bothersome side effects ye methotrexate inosanganisira misoro, kurara, kuchenesa, kuputika kweganda, dutu, nekushaiwa bvudzi.
Zvinokonzerwa nemigumisiro inosanganisira kutyisa kwechiropa, bone marrow kana, kazhinji, mapapu. Ona methotrexate mapeji emagumisiro ezvinyorwa zvakakwana.
Pane Kubatana Kwezvokudya Here?
Zvinwiwa zvinodhaka hazvifaniri kudyiwa pachinotora methotrexate, sezvo zvingakonzera kukanganisa chiropa, zvichiita kuti kuve nechirwere.
Ndeapi Mishonga Inogona Kuita Nehotrexate?
Vanhu vanotora methotrexate vanofanira kudzivirira zvirwere nemararamiro anorarama. Methotrexate inokonzera kuti muviri wechirwere chemuviri udzivirire, saka chirwere chinorarama nehutachiwana chinogona kukonzera chirwere panzvimbo yehutachiona hwemagunha.
Iyo FDA inokurudzira kuchenjerera mukutora methotrexate pamwe neproton pump inhibitor (PPI) , iyo inodhaka inobatsira kuderedza kuwanda kwehutachimu mudumbu. Dzimwe PPI dzakawanda dzinosanganisira Prilosec ( omeprazole), Nexium (esomeprazole) , uye Protonix (pantoprazole). Kunetseka kunonyanya kuratidzwa kune avo vari kutora madhigirii emurefu we methotrexate. Dambudziko nderokuti PPIs inogona kuwedzera serum mazinga (mari inowanikwa muropa) ye methotrexate. High serum levels inogona kureva kuti kune chepfu inopisa ye methotrexate inovaka mumuviri. Mhedzisiro yese yekubatana uku ichiri kuongororwa, asi ikozvino FDA yakabudisa nyevero pamusoro pekutora methotrexate pamwe ne PPI.
Methotrexate inogona kuwirirana nemishonga inotevera:
- Arthritis drugs (ibuprofen, Advil, Motrin, Naprosyn, Voltaren, Lodine)
- Aspirin kana imwe saricylates
- Azathioprine (Imuran)
- Bismuth subsalicylate (Pepto Bismol)
- Carbenicillin (Geocillin)
- Cholestyramine (Questran)
- Ropa rakapfa (Coumadin)
- Cyclosporine (Sandimmune, Neoral)
- Digoxin (Lanoxin)
- Etretinate (Tegison)
- Phenytoin (Dilantin)
- Probenecid
- Proton pump inhibitors (PPIs)
- Sulfa zvinodhaka (Bactrim)
- Thiazide diuretics (Dyazide, hydrochlorothiazide)
Iko Methotrexate Yakachengeteka Panguva Yekuzvara?
Iyo FDA yakarongedza methotrexate sechirongwa X chemishonga. Izvi zvinoreva kuti kuongorora mhuka kana vakadzi vane pamuviri vakaratidza uchapupu hwakanaka hwekuberekwa kusina kunaka. Methotrexate haifaniri kushandiswa panguva yekudzivirira sezvo inogona kukonzera kusununguka kana kupererwa kwepamuviri muhucheche. Varume vanofanira kusiya methotrexate kwemwedzi mitatu musati mimba.
Vakadzi vanofanira kurega methotrexate kune imwe yeivulation yakazara musati mimba. Methotrexate inopinda mumukaka wamazamu, uye inogona kukanganisa mwana anoyamwa. I-FDA inokurudzira kuti methotrexate isasashandiswa kuvakadzi vezera rekutakura kunze kwekuti "kune uchapupu huri pachena hwehutano hwokuti zvinogona kutarisirwa kuti zviwedzere kuwedzera njodzi dzinofungidzirwa."
Inguva Yakareba Sei Methotrexate Inogona Kuitwa Yakachengeteka?
Methotrexate inogona kutora vhiki dzinoverengeka kuti ibudirire pakurapa chirwere cheCrohn. Inofanira kutorwa chete kwenguva yakareba (mwedzi kana makore) pasi pekutariswa kwepedyo kwechiremba.
Kunobva:
Hospira, Inc. " Methotrexate Injection, USP ." FDA.gov. Oct 2011.
Micromedex Consumer Medication Information. "Methotrexate (Nemuromo)." PubMed Health. Dec 2015.