Kuchengeta kurapwa kunogona kukonzera kukanganisika kweMM mune zvimwe
Tysabri (natalizumab) chirwere chinoshandura zvirwere chinoshandiswa mukurapa kudzokera kune vanhu vane multiple sclerosis (MS) . Iyo inopesana kukwanisa kwemasero ezvirwere zvekuzvidzivirira kuti apfuure ropa-uropi hunopesana hunoparadzanisa uropi nemutsipa wesipinha kubva mumuviri wose. Izvo masero aya anogona kukonzera kukuvadza kwemitsipa sezvaanovabvisa zvidziviriro zvavo zvekudzivirira (inozivikanwa se myelin sheath ).
Tysabri inogamuchirwa neU.S. Food and Drug Administration (FDA) kuti ishandiswe muSMS monotherapy (isingafaniri kusanganiswa nedzimwe nzira dzokurapa) uye inotarisirwa intravenously mazuva makumi mana nerimwe.
Ngozi Dzakabatana neTysabri Use
Kunyange zvazvo Tysabri yakaratidzwa kuderedza kudzokorora zvakare kune vanhu vane MS kuburikidza ne 68% inotyisa, haisi kunze kwezvinetso zvayo. Muna 2005, FDA yakabudisa nyevero yebhokisi inopa mazano kuvarwere navanachiremba kuti Tysabri akanga ari pakati pemakumi maviri nemakumi mashanu evashandisi vakawana hutachiona hwehutachiona husingazivikanwi hunonzi progressive multifocal leukoencephalopathy (PML) .
Chimwe chinyanyozivikanwa chinonyanya kunetseka ndechechiitiko chinonzi rebound apo kusagadzikana kana kukanganisa kwechirwere kwakakonzera kudzoka kweSMS kudzokerazve zviratidzo , mune dzimwe nguva zvakanyanya kupfuura apo kana kurapwa kwakatanga.
Kunzwisisa Chigadziriswa Chinoitika
ITysabri yakagadziriswa yakatanga kuonekwa muna 2007 apo vatsvakurudzi veDutch vakaongorora maitiro eMRI evanhu vakanga vari kutora Tysabri asi vaifanira kumira apo mushonga wacho wakambotora kubva pamusika nemhaka yezvinetso zve PML.
Munguva iyi mwedzi gumi nemwedzi, chirwere chemasayendisiti chakawana kuti chiyero chezvipembenene mukati mehutano hwemagetsi zvakange zvichiwedzera kubva pavhareji ye 3.43 pakutanga kwekurapa kusvika kune 10.32 mushure mekurapa kwakamira.
Zvinoshamisa kuti izvi hazvina kuonekwa kuti zvakanyanya kuipa kune vanhu vaive vachirapa kwenguva refu.
Chaizvoizvo, zvaive zvakasiyana. Maererano nekutsvakurudza, avo vainge vawana zvirwere zveTysabri zvakapetwa kaviri kune zviya zvakange zviri mukurapa kwehuwandu hwose hwekudzidza (anenge makumi matatu nemaviri).
Chimwe chidzidzo chakafanana muna 2014 chakatsigira zvirevo izvi uye chakagumisa kuti kukanganisa kwechirapa kwakabatanidzana nekamwe kaviri kowedzera mujodzi yekudzoka zvakare. Kunyanya pamusoro pezvo zvakadaro kwaive kuripo kwekuti chikamu chevanhu ava chakanga chichidzoka zvakare mushure mokumisa Tysabri kupfuura asati atanga kurapwa.
Izvi Zvinotitaurira
Masayendisiti haazive zvachose nei chikonzero ichi chichiitika chichiitika. Izvo zvakave zvichiratidzwa mune mamwe madhiragi eEMS , kusanganisira Gilenya (fingolimod) , uye kune huri huno huno hunoziva pamusoro pezvingaitwa kuti zvidzivirire.
Izvo zvatinoziva ndeizvi: vanhu vari pangozi huru ndivo avo vanotora mwedzi miviri yeTysabri ndokubva vamira. Kana kurapwa naTysabri kuchikurudzirwa, iwe semurwere unoda kuzvipira kurapwa uye unamatira. Iwe haugoni kutora zvinodhaka zvemaawa kana kusarudza kumira kana iwe uchinzwa zviri nani.
Mishonga inogadziriswa inofanira kutungamirirwa neyanyanzvi anozivikanwa uyo anogona kunyatsoziva kana kana Tysabri isisisina kudiwa.
> Sources:
> Fox, R .; Cree, et al. "Chirwere cheSMS chirwere muRESTORE: maawa makumi maviri nemaviri masalizumab ekurasikirwa kwekudzidzira kurapwa." Neurology 2014; 82 (17): 1491-8.
> Sorensen, P .; Koch-Henrikson, H .; Petersen, T. et al. "Kudzokorora kana kuputika kwekliniki kunodzokororazve mushure mekuregererwa kwema natalizumab therapy mune varwere vakawanda veMMS." J Neurol . 2014; 261 (6): 1170-7.
> Vellinga, M .; Castelijns, J .; Barkhof, F. et al. "Kuwedzera shure kwekuwedzera kwechikwata chemukondombera mumutambo weT2 wechirwere mumatachiona anonzi MS-natalizumab." Neurology. 2008; 70 (13): 1150-1.