Tsvakurudzo itsva kutsvaga mishumo ye methotrexate ngozi
Methotrexate inorwisa mishonga inoshandiswa kuporesa mamwe marudzi ekenza pamwe nehuwandu hwezvinetso zve autoimmune , kusanganisira zvakanyanya psoriasis uye rheumatoid arthritis (RA) .
Zvinoshamisa, zvidzidzo zvakawanda zvakaratidza kuti methotrexate inogona, kuwedzera, kuwedzera kungoti yekenza kuvanhu vane RA, kusanganisira melanoma, leukemia, myeloma, kenza yemapapu, uye lymphoma.
Mumakore gumi kubvira apo yekutanga yezviongorori izvi yakabudiswa, pane nharo yakaramba ichitaura pamusoro pokuti ingozi chaiyo inogona kunge yakadini. Iko methotrexate yakachengeteka kushandiswa here, kana pane zvikonzero zvinogona kuisa vamwe vanhu pangozi huru kupfuura vamwe?
Zvakaitwa Nekutsvakurudza Kwokutanga
Muna 2008, kuongorora kweAustralia kwakaongorora nhoroondo dzezvokurapa dzevakadzi makumi matatu nemakumi mashanu nevarume vane RA vainge vashandisa methotrexate vasati vamboenda muna 1986 uye vachienzanisa chiyero chekenza muboka iroro kune yevanhu vakawanda.
Maererano nekutsvakurudza, vanhu vane RA vainge vakurudzirwa ne methotrexate vaiva ne50 muzana yengozi yakakura yekudzidzira kenza yemhando ipi zvayo. Uyezve, vakave nekuwedzera kwemazana mashanu muhutano hwekusava Hodgkin lymphoma (NHL) pamwe nekuwedzera katatu kenza yemapapu uye mungozi yekenza.
Kunze kwevanhu 459 vakabatanidzwa mukudzidza, 87 maitiro akaipa akawanikwa.
Kunyange zvazvo chidzidzo ichi chichitsigira kutsvakurudza kwakapfuura kune njodzi yekenza yemuNHL uye yemapapu kune vanhu vane methotrexate-based therapy, vazhinji munharaunda yezvesayenzi havana kuramba vakajeka kuti kana methotrexate yaiva chikonzero kana chirwere chairo.
Izvi zvaive zvakanyanya kuitika kumaranoma kubva pakagadzirirwa kwekudzidza kwaisabvumira kuti kuiswa kwezviitiko zvakadai sezera kana kuti kubuda kwezuva.
Zvakawanikwa munguva ichangobva kuwanikwa Kutsvaga
Muna 2017, masayendisiti paYunivhesiti yeGenhenburg muSweden akaita shanduko yekuongorora kuti ione zvakakonzerwa nengozi ye melanoma mune methotrexate-vanorwara nevarwere vane RA.
Kushandisa nhamba kubva kuNational Board of Health and Welfare, vatsvakurudzi vakaongorora mafaira emhosva kune ani zvake anopfuura makore gumi nemasere akapiwa mushonga kubva muna 2005 kusvikira muna 2014.
Maererano nekudzidza kwakabudiswa, vanhu vane RA vainge vabatwa ne methotrexate vaingova ne10 muzana mukuru wehutachiona hwemaranoma kupfuura huwandu hwevanhu. Uyezve, vazhinji vezviitiko izvi vaibatanidza vakadzi vakanga vatanga kurapwa mushure memakore makumi manomwe. Sezvo vakadaro, zera rinogona kuita basa rakakura zvikuru rakapiwa kuti melanomas inowanzoonekwa kuvanhu vanopfuura 65.
Vamwe vatsvakurudzi, panguva iyo, vatanga kuongorora sangano reRA nekenza zvisinei nokuti methotrexate. Chimwe chekutsvakurudza kwakaitwa neYunivhesiti yeManchester School of Medicine yakagadzirisa dambudziko kubva pane zvinomwe zvekliniki zvidzidzo zvakabudiswa kubva muna 2008 kusvika muna 2014.
Zvose mapfumbamwe mabhuku akabatanidza zvinongororwa. Vanomwe vakaongorora dambudziko rose rekenza kuvanhu vane RA; vane masere vakatarisa lymphoma, melanoma, mapapu, colorectal, uye nekenza yengara; zvinomwe zvinotarisana nekenza yeprostate; uye vana vakatsvakurudza nezvechirwere chemucheche.
Pakupedzisa kugadziriswa, vatsvakurudzi vakadzoka kuti njodzi yakawanda yekenza yakanga iri yega inenge 10 muzana yakakura kudarika vanhu vazhinji.
Uyezve, njodzi yekamu, kervical, colorectal, uye kenza yeprostate yakanga yakaderera pakuenzanisa.
Izvozvowo hazvina kutendeka kune dzimwe kanza. Pakati pezvakawanikwa:
- Chiyero che lymphoma chakanga chakakwirira kwazvo, kunyanya Hodgkin chirwere chakanga chakawedzera 12 panjodzi.
- Kanzera yemaperembudzi kazhinji yairatidza kuwedzera kweviri.
- Melanoma yakanga ine zvishoma zvishoma ne25 muzana
Hazvishamisi kuti aya aiva kanzura yakanyatsotsanangurwa mukudzidza kweAustralia.
Izvi hazvirevi kuti methotrexate haina kutora chikamu mumukana wekenza. Zvinongotiudza kuti kutarisirwa kwakanyanya kunoda kutorwa kuti kuve nekenza kuongorora muvanhu vane RA kana methotrexate inorayirwa kana kwete.
> Sources:
> Buchbinder, R .; Bherere, M .; Heuzenroeder, L. et al. "Kuitika kwemaranoma nezvimwe zvirwere zvinosanganisira rheumatoid arthritis varwere vanobatwa ne methotrexate." Arthritis Rheum . 2008; 59 (6): 794-9. DOI: 10.1002 / mifananidzo.23716.
> Polesie, S .; Gillstedt, M .; Mwanakomana, H. et al. "Methotrexate kurapwa uye njodzi yezvipembenene zvinouraya melanoma: kuongorora kunyoresa mabhuku-based cohort study." Brit J Derma. 2017; 176 (6); 1492-1499. DOI: 10.1111 / bjd.15170.
> Simon, T ;; Thompson, A .; Gandhi, K. et al. "Kuitika kwechirwere muvarwere vakura vane rheumatoid arthritis: a .meta-analysis." . Arthritis Res Ther. 2015; 17 (1): 212. DOI: 10.1186 / s13075-015-0728-9.