Otrexup Is Single-Dose Autoinjector
Otrexup ( methotrexate ) inonzi subcutaneous, single-dose autoinjector ine mishonga yemishonga methotrexate. Otrexup yakatanga kugamuchirwa neU.S. FDA musi waOctober 11, 2013. Otrexup, yakagadzirwa naAnatares Pharma, Inc. ndiyo imwe nzira yemuromo methotrexate, vial-and-syringe injectable methotrexate, kana imwe carinjector inonzi single-dose, Rasuvo .
Zviratidzo zveOtrexup
Otrexup, a folate analog metabolic inhibitor, yaiva FDA-inogamuchirwa kuti vatungamiri vevanhu vane chirwere chakanyanya, chinoshanda cherumatoid arthritis uye polyarticular vana vechidiki idiopathic arthritis vakange vasina kukwana kugadzirisa mushonga wekutanga. Otrexup yaibvumidzwawo kuitira kutarisa zviratidzo zvinosangana nechisimba, kuporesa psoriasis kune vanhu vakuru avo vasina kukwanisa kupindura kune dzimwe mishonga. Otrexup haIYE inobvumirwa kuitira kurapwa kwezvirwere zveeoplastic.
Administration of Otrexup
Kutanga doses re methotrexate kune 7.5 mg kamwe kamwe kwevhiki kune vanhu vane rheumatoid arthritis, 10 mg / m2 kamwe chete kwevhiki kune varwere vane polyarticular vana vechidiki idiopathic arthritis, uye 10 kusvika ku25 mg kamwe kwevhiki ye psoriasis. Otrexup inoshandiswa se kamwe kamwe-vhiki nevhiki, mujinga mutsva. Inogona kuiswa muhudyu kana mudumbu pane imwe nzira.
Otrexup inowanikwa mumayero pakati pe10 kusvika ku25 mg muzvikamu zvishanu zvemagetsi.
Chimwe chimiro che methotrexate, kunze kweOtrexup, chinofanira kushandiswa kune varwere vanoda muromo, maitiro, maitiro, intra-arterial, kana intrathecal dosing, maawa asingasviki 10 mg pavhiki, madhigiri makuru kupfuura 25 mg pavhiki, madhigirii epamusoro , kana kuchinjwa kwechirwere zvisingasviki 5 mg kukuwedzera.
Contraindications
Otrexup haifaniri kushandiswa nevakadzi vane pamuviri, vana vanoyamwisa, kana avo vane chirwere chechiropa kana kudhakwa. Uyewo, Otrexup inofanira kudziviswa nevanhu vane immunodeficiency syndromes, kusati kwavapo-kushaya ropa, kana kuzivikanwa hypersensitivity kusvika methotrexate.
Zvinowanzovhiringidza Kuchinja
Otrexup inobatanidza nehuwandu hwekushushikana kwakaipa, kusanganisira: kuora mwoyo, kurwadziwa mumimba, dyspepsia, kuputika kwemuromo, muronda wemuromo, kupisa, nasopharyngitis, chirwere, chiropa, kushanda, kusuruvara, musoro, bronchitis, low platelet count, low number white blood masero, kuperevedza kwemarudzi ose emasero eropa, chizivi, photosensitivity, uye alopecia.
Kana iwe uchinzwa chiitiko chakaipa kana kusakanganisika, iwe unogona kuudza iyo ku FDA pa http://www.fda.gov/medwatch/ kana kudana 1-800-FDA-1088. Iwe unogonawo kuonana nemuiti weOtrexup pa http://www.otrexup.com kana nekudana 1-855-Otrexup (1-855-687-3987).
Kubatana Kwemishonga
Kutora aspirin , NSAIDs , kana corticosteroids ne Otrexup inogona kupedzera serum methotrexate mazinga zvichiita kuti kuwedzerwa kuora. Kutora proton pump inhibitors nekushandisa Otrexup zvakare kunogona kuwedzera nekuwedzera serum methotrexate mazinga, kuwedzera njodzi yekutyisa.
Iva nechokwadi kuti chiremba wako ane rondedzero yezvino mishonga yose uye zvigadziri zvaunotora. Iyowo pfungwa yakanaka kushandisa imwe pharmacy, kana zvichikwanisika, nezvemishonga yako yese yemishonga. Zviri nyore kutarisa kushandiswa kwezvinodhaka zvinoshandiswa kana mishonga yako yose iri mumakombiyuta ehurmisiki yaunosarudza.
Manyevero uye Kuchengetedza
Pane nyevero yebhokisi yakasvibiswa inosangana neOtrexup iyo inotaura kuti zvakakomba zvinokonzerwa nehutano uye rufu zvakataurwa maererano nekushandiswa kwe methotrexate. Varwere vachishandisa chiremba vanofanira kuongororwa nokuda kwepfupa remafu, chiropa, mapapu, ganda, uye zvinetso zvekutsvaira. Methotrexate yakave ichitaurirwa kuti inokonzera rufu rwekufa kana kuberekwa kusina kuipa ndicho chikonzero icho chinopesana nekamuviri.
Zvisingatarisirwi zvakanyanya mapfupa emapfupa ekuderedza, kuperesa anemia, uye kushaya mishonga kunokonzerwa nevarwere vanotora NSAID pavanoshandisa methotrexate. Liver toxicity, fibrosis, uye cirrhosis zvinogona kuitika mushure mekushandisa kwenguva yakareba methotrexate. Nhengo dzepneumonitis dzinogona kuitika panguva ipi zvayo uye kunyange nehana shoma ye methotrexate. Diarrhea, ulcerative stomatitis, hemorrhagic enteritis, uye intestinal perforation inogona kuitika. Zvakanyanya, zvinogona kuuraya, kugadzikana kweganda kunogona kuitika. Zvichida kuuraya zvirwere zvinotapukira zvinogona kukura zvakare.
Non-Hodgkins lymphoma nemamwe tumarara zvakataurwa kune varwere vanobatwa nehana shoma methotrexate. Izvo zvinofanira kuonekwa kuti mumamiriro ezvinhu apo yakaipa lymphoma yakagadzirwa panguva yekurapa ne methotrexate, kurega methotrexate kwaive kwakakwana kukonzera kuderedzwa kwe lymphoma.
Methotrexate zvakare inonzi yakakonzera kusabereka mune vamwe varwere, pasi peperm count uye nekuenda kumwedzi kusagadzikana. Izvi zvinogona kuva dambudziko apo methotrexate inoshandiswa uye kwenguva yakati mushure mokumiswa.
Shoko Rinobva
Vanhu vari kushandisa Otrexup vanofanira kuva nenguva yekuongororwa ropa, kusanganisira ropa rose rakawanda, mazwi enzymes, uye maitiro epimpomu. Kana nyaya yemapurmari inenge ichifungidzirwa, chirongwa chepfupa x-ray uye mapirmoni chinogona kudiwa.
Vanhu vanoshandisa Otrexup vanofanira kuva nekuziva kwezvinogona kukanganisa migumisiro, kuitira kuti vagoziva uye vaudze nyaya pakarepo pavanenge vachiitika. Ichokwadi kuti urongwa hwezviitiko zvinotambudza zvinotyisa, asi yeuka, vanhu vazhinji vanoshandisa methotrexate vasina matambudziko. Kuziva uye kuongorora kunokosha.
Sources:
Otrexup. Kunyatsorondedzera Mashoko . Revised 3/2016.
Otrexup Approval History. Drugs.com.