Oral Flupirtine: Vakafa Mumvura?
Kwete Pakare Mupayipi?
Chirwere chinonzi oral flupirtine chakanga chiri kuratidza chivimbiso senzira itsva yehutachipatria yekurapa zvakare muna 2008, apo yakaita sekuti mushonga wacho waizotanga kushandura nzira yawo kuenda kuRAA kugamuchirwa. Zvisinei, kubva panguva iyoyo, zvinoratidzika kunge zvakadonha kubva kune radar.
Oral flupirtine yave iripo kuEurope kubvira kuma1980. Ikoko, inoshandiswa kurapa marwadzo kubva kune zvimwe zvinyorwa, kusanganisira kuvhiyiwa, kenza, tsvuku uye chiropa chirwere.
Rine rurefu rurefu semutambo wakachengeteka uye unoshanda.
Iyo US FDA yakapa Adeona Pharmaceuticals muInvestigational New Drug Application kuitira kuti itange kutanga miedzo pa fibromyalgia. Zita rokuti Effirma rakanyoreswa kwairi.
Adeona yakagadziriswa nePipex Pharmaceuticals kushanda kune FDA kufungidzira, asi iyo yekare yePipex website yave ikozvino. Adeona akazoshandura zita rayo kuva Synthetic Biologics, uye Effirma haatauri kupi zvako paSynthetic's website. Hapana chakaiswa neCDA, uye hapana zvidzidzo zvitsva zvakabudiswa.
Nokuti iko zvino, zvinoratidzika sekuti ichi chirwere chakafa mumvura muUnited States Izvo zvinosuruvarisa, sezvo zvakasiyana nedzimwe mapainkiller uye fibromyalgia mishonga mune zvinonakidza uye zvinogona kubatsira.
Iro Oral Flupirtine Ichishanda
Oral flupirtine haisi opiate / narcotic , uye haisi mishonga inopesana nemanzwiro kana anti-seizure , iyo inoita kuti ive yakasiyana zvikuru nedzimwe mishonga inoshandiswa kurapa fibromyalgia .
Adeona akanga ataura kuti aitarisira kuratidza mishonga inorapwa kupfuura kurwadziwa kwe fibromyalgia, asiwo inovandudza manzwiro, kuneta, zvinetso zvekunzwisisa, kushungurudzika kwehope uye basa rose.
Oral flupirtine inoshanda zvakasiyana nekurapa marwadzo anowanzoitika pamusana pokuti inoratidzira sei marwadzo emakwara muuropi.
Opiates , iyo inowanzoshaya basa kune vanhu vane fibromyalgia, simudzai nhamba ye dopamine, iyo inonyanya kukonzera kufara. Panzvimbo pokudzivisa kurwadziwa, maopiates anoita kuti usatarise zvishoma pamusoro pemarwadzo.
Oral flupirtine, kune rumwe rutivi, ine zvinyoro zvishoma pane zvimwe zvivako muuropi zvinonzi NMDA receptors uye, somugumisiro, inoderedza mazinga ako e glutamate . Glutamate inonzi neurotransmitter inoita kuti uropi hwako huve nesimba.
Zvidzidzo zvakabudiswa muna 2008 uye 2009 (Harris) zvinoratidza kuti vanhu vane fibromyalgia vanogona kuva nehupamhi hwe glutamate mune dzimwe nzvimbo dzeuropi uye kuti kana maronda e-glutamate akangodonha, saizvozvo marwadzo anowedzera. Izvo zvinoita muromo flupirtine munhu anonakidza kwatiri.
Vanhu vane fibromyalgia vane nguva yakaoma zvikuru kubvumira mishonga. Mishonga yemishonga inowanzoshandiswa kutitapa, panguva iyo, ine nguva yakareba yemigumisiro uye inogona kunyanya kuoma kushivirira. Oral flupirtine reurope yeEurope sechirwere chisina kujeka ine michirwe yakaipa inoitawo kuti inakidze. Iwe haufaniriwo kuramba uchirapa zvishoma nezvishoma zvechirwere, zvimwe, sezvaunoita nemishonga yezvino ye fibromyalgia.
Chii Zvino?
Zvinoratidzika sega tariro yedu iye zvino ndeyokuti Synthetic kana imwe kambani inosarudza kutanga kutsvakurudza muromo wemvura.
Kunyange kana zviri zveimwe mamiriro ezvinhu, zvingatibatsira - FDA mvumo inoreva kuti yaizove pamusika muU.S. uye vanachiremba vanogona kuiraira isu kubva parairi.
Kunyange zvakadaro, izvozvo zvinotora makore. Saka kunze kwekuti iwe uchida kutamira kuEurope, haisi kutaridzika iwe uchakwanisa kutora muromo flupirtine chero nguva pfupi.
Sources:
Harris RE, et al. Arthritis uye rheumatism. 2008 Mar; 58 (3): 903-7. Dynamic level ye glutamate mukati me insula inobatanidzwa nekuvandudzika mune marwadzo akawanda munzvimbo ye fibromyalgia.
Harris RE, et al. Arthritis uye rheumatism. 2009 Oct; 60 (10): 3146-52. Yakawanda inonzi insular glutamate mu fibromyalgia inobatanidzwa nekurwadziwa kwekuedza.