Iyi dambudziko rinowanzoitika muhosha yaPasinson inoda nzira yekufungisisa
Levodopa ndiyo mishonga "yegoridhe" yemishonga yaPasinson, iyo inoreva kuti ndiyo inobatsira uye inotanga kushandisa mishonga. Inoshanda kuburikidza nekushandurwa kuva dopamine, iyo inobatsira munhu kutama uye kudzora masimba avo.
Zvinosuruvarisa asi, nokuda kwevanhu vakawanda, sezvo Parkinson iri kufambira mberi, levodopa haishandisi zvakare mukuparadza kana kudzora zviratidzo zvemunhu.
Izvi ndezvekuti, nekufamba kwenguva, levodopa inotanga kupfeka nekukurumidza nekukurumidza, zvichikonzera mishonga "on-off phenomenon."
Zvakanaka, iwe paunotora madhiraji emishonga seyevodopa purogiramu yenguva dzose, haufaniri kuona zvakawanda zvekusiyana kwezviratidzo zvako pakati pemadhora. Mune mamwe mazwi, zviratidzo zvako zvinofanira kuramba zvichingoitika nguva yakawanda, pasinei nokuti iwe wakapedza kushandisa mushonga wako.
Zvisinei, apo in-off chiitiko chinotanga kuPalinson's disease, iwe uchanzwa zviri nani ("pane") sechirwere chitsva chemishonga yako inotanga kushanda, uye yakaipa ("kure") usati wafanirwa nemumwe mubairo . Pakupedzisira, nguva ye "on" states inova shoma uye kupfeka "kubva" kunoitika nokukurumidza (nekukurumidza kune imwewo mukana we levodopa).
Maitiro aParkinson's On-Off Phenomenon Anofunga
Dzimwe nyanzvi dzakatsanangura "pa" nguva sokufananidzira kuisa chiedza, uye "nguva" nguva apo magetsi achienda.
Mune "pane" mamiriro ezvinhu, munhu ane chirwere cheChinsinson anganzwa anesimba uye anokwanisa kufamba-famba nyore nyore. Zvisinei, mune "nzvimbo", munhu wacho angave akaoma kwazvo, anonoka, uye angave asingakwanisi kutamira zvachose kwemaminitsi mashomanana. Munhu angave akaomawo kutaura, uye iwe unogona kumuona iye achitaura mazwi avo.
Sezvaunogona kufungidzira, iyo "kunze" mamiriro ezvinhu inogona kunge isina kunetseka.
Kutarisira Phenomenon In-Off muPasinson
Mune vamwe vanhu vane chirwere chePasinson, "kubuda" kuchinja kunenge kuchiitika. Vanoziva kuti migumisiro yevavodopa ichapedza mushure maawa anenge matatu, saka vanogona kuronga maererano.
Kune vamwe vanhu, zvinosuruvarisa, ku "on-off" kuchinja kunenge kusingazivikanwi, uye izvi, chokwadi, ndiyo yakaipisisa mamiriro ezvinhu. Hapana anoziva kuti nei kushanduka kusingaziviki mune dzimwe nguva.
Izvozvo zvakati, pane zvishoma zvingasarudzwa iwe kana iwe waunoda kutanga kutarisana ne-on-off phenomenon.
Kune vamwe vanhu, kuchinja kwemotokari kunofanirwa kupindura maitiro ekudzora-kusunungurwa kwevevodopa (inonzi Sinemet CR). Zvisinei, iyo-control-release release yevodopa haishande zvakanaka kune munhu wose uye zvinosuruvarisa, inogona kuita kuti dzimwe zviratidzo zvirambe dzichiwedzera.
Panzvimbo pokutsvaga kune rumwe rudzi rwevodopa, chiremba wako anogona kuderedza nguva pakati peevodopa doses nemaminitsi anenge 30 kusvika ku60 (zvikurukuru muPasinson yakakwirira).
Zvimwe, chiremba wako angakurudzira kuwedzera mishonga. Dopamine agonists, kana yakawedzerwa ku levodopa, inogona kuderedza nguva yaunopedza "kubva," asi inouya nehutano hwemamwe matambudziko akadai sekuona maitiro uye maitiro ekumanikidzira.
COMT inhibitors seComtan (entacapone) inogona kuramba ichiwedzera uye inowedzera mhizha yeLevodopa asi inogona kuwedzera migumisiro yaro kubva nayo.
Pakupedzisira, kana uwedzerwa ku levodopa, MAO-B inhibitor inogona kubatsira (kunyange nemigumisiro). MAO-B inhibitor inoshanda nekudzivirira enzyme iyo inowanzoita kuti dopamine muuropi iite.
Nokuda kwechirwere chePacinson, yakakonzerwa nemukumbo gel inodhaka yevavodopa inogona kubatsira, uye mune zvikamu zvakakomba zvezvipfeko izvi zvichiita, mushonga unoshandiswa unonzi Apokyn (apomorphine hydrochloride injection) unogona kubatsira.
Shoko Rinobva
Izvozvi-zvinoitika chinetso chinetso chisina kunaka mukurapa chirwere chePasinson, uye apo vamwe vanhu vanogona kuzviona pakutanga kwekutanga kwevodopa, vanowanzozviona mumakore matatu kusvika mashanu.
Nepo kune nzira dzakasiyana-siyana dzokurwisana nechiitiko ichi, bhiza rako rakanakisisa nderokurukura zvose zvaunogona kuita nechiremba wako. Zvaunoda iwe pachako zvinogona kunge zviri nani zvakakosha kune rimwe zano kana mishonga inopesana nezvimwe- izvo zvinoshanda zvakanyanya kuti iwe usasvike kune mumwe munhu.
> Sources:
> Fasano A et al. Intrajejunal levodopa inokonzerwa nehutachiona hwePacinson yakakura: kwenguva yakareba zvinokonzerwa nemotokari uye zvisingaiti motokari uye zvinokonzera hutano uye mutarisiri hwehupenyu hwehupenyu. Yurope Ongororo yeMedical and Pharmacological Sciences. 2012 Jan; 16 (1): 79-89.
> Martinez-Martin P et al. EuroInf: kuenzanisa kwakawanda kwechiitiko chekuongorora apomorphine uye levodopa kuputirwa muhosha yaPasinson. Movement Dambudziko. 2015 Mbudzi; 30 (4): 510-6.
> Pahwa R, Lyons KE. Chirevo cheLevodopa-chakavhara muPalinson's disease: kuziviswa uye kutungamirirwa. Curr Med Res Opin . 2009 Apr; 25 (4): 841-9.
> Stocchi F, Jenner P, Obeso JA. Ndeapi iyo levodopa motokari yekuchinja inotanga kuonekwa muhosha yaPasinson? Eur Neurol . 2010; 63 (5): 257-66.
> Tarsy D. (2017). Kuchinja kwemotokari uye dyskinesia muPalinson's disease. Hurtig HI, ed. Kusvika pari zvino. Waltham, MA: UpToDate Inc.