Kushandiswa kwenguva refu kana kushandiswa kwepamusoro kunobatanidza zvirwere zvakakomba
Proton pump inhibitors (PPIs) iboka remishonga ine chinangwa chokuderedza dumbu reAIDS. Ive yakashandiswa kurapa yakawanda yegastric acid-inorwara zvirwere kwemakore anodarika makumi maviri uye inozivikanwa kuva yakachengeteka uye inobudirira-yakawanda kuitira kuti inonyanya kubvisa H2 blockers semushonga wekusarudza.
Izvi hazvirevi kuti maPPIs haasi kunze kwematambudziko kana zvikanganiso.
Kunyange zvazvo yakawanda yemigumisiro yacho ine unyoro uye inogadziriswa, kune zviitiko zvakawanda zvakashata zvinogona kuitika nekushandisa kwenguva refu kana kushandiswa kwepamusoro. Izvi zvinosanganisira zvinetso nehuwandu hwemaminerari, hunochinja muhutachiona hwemapfupa, uye huwandu hwehutachiwana hwezvirwere zvisingaperi.
Iyo Proton Pump Inhibitors Inoshanda Sei
Proton pump inhibitors inowanzoshandiswa kurarisa zvinetso zvakadai segastroesophageal reflux chirwere (GERD) , peptic ulcers , uye zvirwere zvakanyanya , vanachiremba vanogona kuronga kushandisa PPIs voga kana kuti pamwe chete nemasikirasi. Inogonawo kushandiswa mukubatana nemamwe maantibhakitiriya paanobata Helicobacter pylori (bhakitiriya inowanzobatana nemakumbo echirwere anoramba achiita).
PPIs inoshanda nekusungira kune imwe sero pamadziro emudumbu anonzi parietal cell ine chinangwa chokubudisa hydrochloric acid (HCL). Nokuita kudaro, chirwere hachikwanise kuvhara HCL, zvichibvumira kuti zvipembenene zviporese uye zvisaita kuti zvisiyane.
PPIs yakasiyana neH2 blockers muyo maPPIs akavhara mapumpu asidi apo H2 inogadzirisa chete inodzivisa zviratidzo zvinotungamirira kushandiswa kweA acid. Nokuda kweizvi, PPIs inoshanda kwemaawa makumi maviri nemasere uye inopa zororo kusvika maawa 72. H2 vachengeti, zvakasiyana, shanda maawa gumi nemaviri.
Zvinyorwa zveProton Pump Inhibitors
Kazhinji kutaura, imwe PPI haina kusiyana nezvose izvi kubva kune vamwe.
Vose vane nzira yakafanana yekuita uye yakafanana mitengo yekubudirira. Parizvino maPI anogamuchirwa anosanganisira
- Prilosec (omeprazole)
- Prevacid (lansoprazole)
- Protonix (pantoprazole)
- Aciphex (rabeprazole)
- Nexium (esomeprazole)
- Dexilant (dexlansoprazole)
Pasinei nokufananidzwa kwavo, mamwe maPPIs anotorwa seanobudirira mukurapa mamiriro ezvinhu chaiwo. Semuenzaniso, Dexilant uye Protonix havawanzoshandiswa kurapa hutachiona hweH. Pylori ; vamwe vari. Pamusoro pekunamatira kwekunetseka kwepfungwa, Prilosec uye Prevacid vanokurudzirwa apo vamwe vasiri. Sezvo zvakadaro, zvakakosha kutaura nachiremba wako kuti ave nechokwadi chokuti kushandiswa kwePPI kwakakodzera.
Migumisiro Yechiratidzo uye Kubatana
Kana inotorwa kwenguva pfupi, yakawanda yemigumisiro ine chokuita nePP! kushandiswa kwakanyoro uye kwenguva pfupi. Yakawanda inosanganisira kuvhiringidzika, kurarisa, flatulence, misoro, kushungurudzika mudumbu, kushungurudza, uye kurutsa.
kuwedzera huchapupu hunoratidza kuti kushandiswa kwenguva refu kungaguma nezvinetso zvakakomba. Pakati pavo:
- Izvo zvave zvataurwa kuti kushandisa PPI kunogona kupindira nekudyiwa kwe calcium, zvichiita kuti mapfupa afuke mune dzimwe nguva. Mukupindura, US Food and Drug Administration yakabudisa nyevero muna 2011 vachirayira kuti pamusoro pe-counter-PPI inofanira kushandiswa kwemaawa masere masere panguva imwe chete kusvika kune mishonga mitatu pagore.
- Kubvira kwenguva refu kushandisa PPI kwave kuchibatanidzwa nekuwedzera kwechidiki muhutano hwepagumisi inowanikwa munharaunda uye chirwere cheClostridium difficile .
- Zvidzidzo zvakaratidza kuti kushandiswa kwePPIs kwemakore gumi kune 12.5 muzana wekuda kwekukurira zvirwere zvisingaperi zvepfungwa, zvishoma kudarika 8.5 kubva muzana zvakaonekwa muhuwandu hwevanhu.
- Kuongorora kwakadaro kwakaratidza kuti vanhu vakabata PPIs kwemakore manomwe vaine 13 muzana mukana wekuwana dhementia kana vachienzaniswa nevaya vasina.
Zvakawanda zvemigumisiro iyi yakaipa inowanikwa yakabatana nekuti PPI haisi kungovhara mapumpu asiri mumuviri asi mune imwe muviri wose, zvakare.
Izvi zvinosanganisira chikamu chesero inonzi lysosome inoshandisa asidi kubvisa tsvina. Pasina nzira yekuita nayo, tsvina inogona kuunganidza uye inokonzera sero kuti iwedzere uye yakwegura. Izvi zvinogona kuenzanisa kuwedzera kunoonekwa muzvidzidzo.
Izvo zvinowanikwa zvinosimbisa chokwadi chokuti maPPIs anofanira kungoshandiswa chete kwekusunungurwa kwenguva pfupi kana kurapwa panzvimbo pekuita nzira yekudzivirira zvirwere zvepabonde kwenguva refu.
> Source
- > Jacob Schoenfeld, J. uye Grady, D. "Migumisiro Yakaipa Yakasangana neProton Pump Inhibitors." Nyaya yeAmerican Medical Association. 2016: 176 (2): 172-174.