Mishonga inonzi Nonsteroidal anti-inflammatory pain, inowanzonzi NSAIDs (inonzi in-sayds), ndiyo imwe yemishonga inonyanya kupiwa, kunyanya kune varwere vane maitiro emapfupa akaita sarthritis, bursitis, uye tendonitis. Iyi mishonga inowanika pane-the-counter (semu Ibuprofen, Motrin, Aleve) kana semishonga (semuCelebrex, DayPro, Relafen).
NSAIDs zvinobudirira pamarwadzo ose ekurwadziwa (analgesia), uye kuderedza kuzvimba (anti-inflammatory).
Maitiro Avanoita
Mishonga inoshanda kuderedza kupisa inouya mumapoka maviri makuru:
- Steroid ( sainzi Cortisone )
- Non-Steroidal Anti-Inflammatory Medication (NSAIDs)
Steroid yemishonga inoshandiswa mukurapa kwekuputika inobva kune hormone yakasikwa inogadzirwa nemuviri unonzi cortisol. Kunewo mamwe maitiro e-steroids (kusanganisira cholesterol uye hormone dzepabonde), asi chikamu chechitatu ndeche simba rinopesana nekuputira. Steroid mishonga inogona kupiwa muromo, chirongwa, kana sejojo dzakataridzika , sezvinowanzoshandiswa mumatope.
NSAIDs inoshanda kubvisa zvinoitika zve enzyme inonzi cyclooxygenase. Iyi enzyme yakakosha mumuviri wako pakugadzirwa kwe prostaglandin. Iyo prostaglandin inokonzera kubvunda uye kurwadziwa mumamiriro ezvinhu akafanana neArthritis kana bursitis. Nokudaro nekupindirana nebasa re cyclooxygenase, unoderedza kuve kweprogaglandin, uye kuderedza kurwadziwa nekudzivirira kunobatanidza nemamiriro aya.
Zviri nyore, zvakarurama?
Zvakanaka, pane zvakawanda kwavari. Prostaglandins inewo mamwe mabasa anokosha mumuviri. Imwe rudzi rwe prostaglandin (kune marudzi akawanda) inobatsira kutarisa mudumbu nemaviri anodzivirira (anonzi gastric mucosa). Apo vanhu vanotora mishonga yeNSAID, kubudiswa kwemvura inochengetedza kunogona kuderedzwa, uye vamwe vanhu vari pangozi yekudzivirira zvironda zvepamu.
Zvitsva / Prescription NSAIDs Zviri nani?
Mumakore akawanda apfuura, mamwe mishonga mitsva yakasvika pamusika; izvi zvinowanzozonzi COX-2 inhibitors . Yeuka, yese NSAID inoshanda ne cyclooxygenase (COX). NSAIDs zemazuva ano (semuIbuprofen, Motrin, Aleve) dzinopesana nezvose COX-1 ne COX-2. COX-1 uye COX-2 zvose mapoka e-cyclooxygenase enzymes anoshanda mumuviri wako. Mishonga mitsva (semuenzaniso Celebrex) inonyanya kushanda ne COX-2, uye inobvumira COX-1 kuti iite zvakanaka. Nemhaka yokuti COX-1 inonyanya kukosha mukugadzira mbatya yakachengetedza mumatumbo ako (gastric mucosa), idzi dzeNSAID idzva dzinofungidzirwa kuti hadzina ngozi yekukonzera maronda emudumbu.
Izvozvo zvakati, NSAID idzva hadzina kuratidzirwa kushanda chero chipi zvacho chiri nani pane COX-2 enzyme. Nokudaro, COX-2 inhibitor ine ruzivo rwekuve nehuwandu hwemigumisiro yechirwere, asi kwete ikozvino kununurwa kuri nani kubva kune zviratidzo.
Mbiru-Migumisiro yeNSAIDs
NSAIDs inogona kuwanikwa pane-the-counter, asi izvozvo hazvirevi kuti ivo vane kunze kwezvingave zvakakomba migumisiro. Nzira yakanyanya kufanana-inokonzera kusuruvara kwemuviri. Chikonzero cheizvi chinofungidzirwa kuti chinobva pamigumisiro yemudumbu. Kana kushatirwa kwakanyanya, kunogona kutungamirira kumaronda eropa , uye zvinogona kunge zvakakomba zvikuru.
Usati watanga kutora mishonga yeNSAID unofanirwa kutaura nechiremba wako. Iva nechokwadi chekutendera chiremba wako kuziva nezvimwe zvinetso zvezvehutano zvaunazvo, kunyanya kuwedzera kwehutano, chirwere cheputi, zvinetso, kana dumbu. Mukuwedzera, regai chiremba wenyu azive zvimwe mishonga iwe unogona kunge uri kutora, uye kana iwe uine humwe hunozivikanwa hwemishonga yemishonga.
NSAIDs HAII KUTI ishandiswe kana:
- Iwe uri nepamuviri
- Iwe uri kuyamwa
- Iwe une nhoroondo yemaronda emudumbu
- Uri kutora ropa rinopisa mishonga
NSAID dzinofanira kushandiswa chete pasi peCHIKAMU chekuchengetedzwa kwechiremba kana:
- Iwe une asthma
- Iwe une zvinetso zvechiropa
- Iwe une zvinetso zvemwoyo
- Iwe une zvinetso zvetsvo
Pasi Pasi: NSAIDs Yakachengeteka here?
Nonsteroidal anti-inflammatory medication yakachengeteka uye inogona kuva yakabudirira zvikuru. Kazhinji migumisiro inogona kuwanikwa nekushandiswa kwenguva shoma yenguva. Izvozvo zvakati, mishonga iyi inogona kuve nemigumisiro uye haigoni kushandiswa nemunhu wese. Kunyange zvazvo vanhu vazhinji vane chirwere chinokonzera kutuka vanogona kuwana NSAIDs kuti ibatsire, iwe unofanira kugara uchitaura nechiremba wako kana uri kufunga kutanga imwe yemishonga iyi.
Sources:
Berger, RG "Nonsteroidal Anti-inflammatory Drugs: Kuita Zvisarudzo Zvakarurama" J. Am. Acad. Ortho. Surgery., Gumiguru 1994; 2: 255 - 260.
van Tulder MW, et al. "Kwete-steroidal anti-inflammatory drugs for low-back pain Chirongwa cheChchrane chekuongorora kwakagadzirika 2006 Nyaya 1.