Pain Signal Influencers
Prostaglandin ndiwo mahomoni anowedzera simba pamusoro pehutano hwepanyama mumuviri wako. Vose vane maitiro akanaka uye akaipa pane hutano hwako. Mune mamwe mazwi, prostaglandin inoshandisa homeostasis, asi inokurudzirawo zvirwere zvirongwa.
Purpose
Izvi zvenguva pfupi zvinorarama zvinogadzirwa kubva kumafuta ane acid, uye vanoita basa mumabasa akawanda ekutanga.
Mamwe emabasa aya anosanganisira, semuenzaniso, vasodilation uye vasoconstriction. Vasodilation uye vasoconstriction,, zvakananga, iyo inotanga kushandura ropa yevhu inotanga nekuvhara. Zvimwe zvinosanganisira bronchoconstriction, iyo inopesana nemhepo inotenderera, kuvhara ropa, uterine contractions, fever, nekuchengetedza mishonga yakadai sedumbu rako.
Pamwe chete nezvinhu zviri muurongwa huri pamusoro apa, prostaglandin inokonzera marwadzo ekurwadziwa uye inodzora kuputika, miviri miviri inoshandura iyo inobatsira anenge munhu wose anobata nemutsipa kana kuti shure.
Maererano nehurukuro ya2003 muChistorical Structure Biology , kune madzishe makumi maviri nemasere eve prostaglandin.
Mishonga Inotarirwa Prostaglandins
Nokuti prostaglandin inotora basa rinokosha pakutanga uye kupfuurira kuputika, mishonga yakawanda yakave yakagadzirwa pamusoro pemakore ekurwisana nemabasa avo. Iyi mishonga inonzi inoshanda pamwe chete uye inodhura, uye vanhu vari pasi rose uye pasi kuburikidza nemakore vave vachidzoka kwavari kuti vatsigire.
Munguva dzekare, maruva emagungwa aishandiswa kugadzirisa marwadzo uye kuderedza fivhiri, uye mazuva ano vazhinji vagadziri vemarudzi ose vanokurudzira muti uyu kune vashandi vavo vane feverish. Muma1820s, iyo inoshandiswa inoshandiswa yemavillow gark yakagadzirirwa kuva salicylic acid. Asi apo varwere vaine zvinetso zvakanyanya zvemuviri, kusanganisira kubuda uye kurutsa, semugumisiro wokutora salicylic acid, acetylsalicylic acid yakatanga kushandiswa panzvimbo yayo.
Muma 1890, acetylsalicylic acid yakatanga mumusika saAspirin nekambani inozivikanwa iye zvino uye seyezvino sa Bayer.
COX Inhibitor Zvinodhaka
Muma1960 kirasi yemishonga inonzi phenylolkanoic acid yakawanikwa yekuderedza kupisa nekurwadziwa. Aya maiti anoita izvi nokudzivirira enzyme cyclooxygenase, kana COX. (COX enzymes inowanzotanga kuita mukutanga kweve prostaglandin.) "Painkillers ne prostaglandin" nyaya inoti zvitatu zve COX zvakawanikwa: COX 1 inodzivirira GI tract yako, COX 2, iyo inobatsira pakuputika, fivha , uye kurwadziwa, uye COX 3 iyo inowanika kunyanya muuropi. Inonyatsozivikanwa COX inhibitors (iyo iripo pamusika) yekutambudzika nekuputika-rudzi rwakatorwa nevanhu vane mitsipa kana kurwadziwa shure-dzinosanganisira aspirin uye ibuprofen ( Advil ). Aspirin uye Advil inodzivisa zvose COX 1 uye COX 2 enzymes. Zvichizivikanwa nemigumisiro yemishonga iyi ndeyekuonda uye kubuda ropa muchigadziko chemukati.
Advil zvakare inouya nechinetso chekurwadziwa kwemoyo uye chirwere, kusuruvara.
Ichokwadi, kunze kweAspirin, yose isiri-steroidal anti-inflammatory drugs (NSAIDs) inouya neye FDA "yebhokisi-bhokisi" yekunyevera kuti kutora mishonga kunosimudzira ngozi yehutano hwehutano.
Iwe unogona kuyeuka Vioxx naBextra , marwadzo aimbova akavimbisa akadzingwa akadzingwa kubva mumusika muna 2004. Chiito chemishonga iyi chaiva chokudzivisa chete COX 2 enzyme; saizvozvowo, vaizivikanwa se COX 2 inhibitors. Kubatsirwa kwavo kwaiva nemigumisiro yemigumisiro yemudumbu yakange yaenda; chinetso chaiva chokuti panguva imwe chete iyi madhiragi aya ainakidzwa ne-blockbuster mumusika, zvakagadzirirwa kuti COX-2 inhibitors yakawedzera dambudziko rekukurira uye kunyange kuuraya mwoyo mwoyo nekurova.
MunaSeptember ya2004, Merck akazvidira kubudisa Vioxx pamusika. MunaEpril 2005, FDA yakaraira Pfizer muiti wezvinodhaka kuti abvise Bextra kubva pamusika asi akabvumira Celebrex (Celecoxib) kuti igare, iyo inoita kusvikira nhasi.
Shoko kubva
Zvinonyatsozivikanwa kuti kuputika ndiko pamidzi yezvirwere zvemazuva ano, zvinosanganisira kurwadziwa kusingaperi. Zvinonyatsozivikanwa kuti kutora mishonga yekugadzirisa matambudziko anokonzerwa nokuputika kunogona kuuya nemigumisiro, mamwe acho anogona kunge akaoma, zvechokwadi.
Kuti zvivepo, vazhinji vanopa utano, varwere, uye mishonga yemasikirwo evashandi vanotsigira kana kutevera kudya kunopesana nokuputika Nyaya yakabudiswa muHarvard Women's Health Watch yakarondedzera kuti zvidzidzo zvakawanda zvakaratidza kudya zvinogona kuva nekupikisa-kupisa simba.
Kuziva kuti ndezvipi zvingabatsira kusimbisa chikonzero chekudya kunogona kubatsira kurwisana nemigumisiro yekuputika.
Vamwe vanhu vanotorawo marangi anopesana-kupisa kana zvidimbu , zvakadai sewillow bark, iyo yakakurukurwa pamusoro apa.
> Sources:
> Mharidzo. Painkillers uye prostaglandins. Natural Structural Biology. 2003
> Harvard Women's Health Watch. Zvokudya zvinorwisa kuputira August 2017.
> Ricciotti, E., PhD, FitzGerald, Garret A., MD. Prostaglandins uye Inflammation. Arterioscler Thromb Vasc Biol. May 2011.