Chirwere cheshuga chinowanzoenda chisingaoneki kusvikira chichikwira mberi, asi nyanzvi dzinofunga kuti kunyanya kuongororwa kwakakosha kunopa kurapa kwakanakisisa. Kuti vabatsire mukufungidzira kwokutanga, chirwere cheshuga chekushaya chirwere chemashuga chinogona kufungidzira dambudziko remunhu rekukura kwechirwere cheshuga nguva refu chirwere chisati chaitika. Imwe nzvimbo inonyanya kufarira inhengo yezvirwere.
Antibodies muShuga
Zvirwere zvepamuviri mapuroteni chaiwo anowanikwa muropa uye kune imwe nzvimbo mumuviri. Antibodies inoona uye inorwisa zvinhu zvekunze mumuviri, zvakadai semavirusi uye mabhakitiriya. Dzimwe nguva, zvirwere zvinopesana uye zvinorwisa zvirongwa zvemuviri. Kana izvi zvikaitika, zvirwere zvisingaiti zvinonzi autoantibodies. Kazhinji, mune varwere vane chirwere cheshuga chechirwere, autoantibodies kurwisa uye kuparadza insulin-inobudisa islet beta masero mupancreas. Izvi zvinorwisa zvirwere zvemuviri zvinogona kuitikawo kune varwere vane chirwere chechirwere cheshuga, asi kashoma.
Masayendisiti akacherechedza zvirwere zvakasiyana-siyana zvinoratidzika zvakabatana nekukura kwechirwere cheshuga, kusanganisira glutamic acid decarboxylase 65 antibodies (GADA) uye islet cell antibodies (ICA). Aya ma antibodies anorwisa mapuroteni asingadiwi mukati uye pamasero e-beta.
Mune zvimwe zviitiko, vanhu vane chirwere cheshuga chechirwere chechirwere vane chirwere chepamusoro chemasimba ekurwisa kuti vadzivirire kunze kwekurwisa, pamwe chete ne autoantibodies inorwisa zvirongwa zvemuviri.
Iyo autoantibody kurwisa inofungidzirwa kuti inoparadza iyo chaiyo masero ayo ma antibodies anochengetedza.
Zvikamu makumi mapfumbamwe nemashanu kubva kune vana vanorwara nechirwere cheshuga 1 vane huwandu hwakawanda hweI ICA uye autoantibodies zveGADA. Kusvika ku25% yevanhu vane vanhu vakuru-chekuita chirwere cheshuga 2 vakasimudza mazinga evanhu ava.
Antibodies Mukutanga Kuongorora
Kutsvakurudzwa kwemazuva ano kwakaratidza kuti kuvapo kwe autoantibodies yeGADA kunogona kuva yakasimba yekufananidzira chiratidzo chekupedzisira kwechirwere cheshuga. Muzviitiko zvakawanda, idzi autoantibodies dziripo zvisati zvaitika zviratidzo zve chirwere cheshuga kana prediabetes inopinda. Kushandisa kuongororwa kweropa kuvharidziro yeiyi autoantibodies - kunyanya kune vakoma vevaya vakatoonekwa vane chirwere cheshuga chechirwere cheshuga - vanogona kubatsira kufanotaura kana munhu ari njodzi yekudzivirira chirwere cheshuga uye rudzi rwechirwere cheshuga chinogona kukura. Kuziva kwakadaro kwakadaro kunogona kuita kuti zviyero zvinodzivirira zvirambe zvichitanga kutanga kwechirwere.
Antibodies muShuga Chekuita
Vanhu vazhinji vanoita chirwere cheshuga chechipiri nokuti vane kuwandisa uye vane mararamiro ekugara. Zvisinei, vamwe vevanhu vane chirwere cheshuga cheshuga 2 vanogona kunge vane antibodies uye autoantibodies pamakwikwi akaenzana kana akakwirira kudarika avo vane chirwere cheshuga chechirwere. Varwere vanorwara vane chirwere cheshuga chirwere cheshuga vangada kuedza kuongororwa ropa kuti vaone kana vane autoantibodies varipo mumitumbi yavo. Rudzi rwechipiri diabetics nepamusoro mazinga e autoantibodies zvingangodaro dzinoda insulini munguva yemberi. Idzi ruzivo rungabatsira kubatsira kufanotaura dambudziko rechirwere chevo uye kana vangazopedzisira vachida insulin majekiseni kuti vararame chirwere cheshuga.
Chirwere Chekupedzisira Chirwere Cheshuga Chekukwegura: 'Mukati-pakati' Chirwere cheshuga
Vamwe vanhu vanokudza vanhu vakuru-chinokonzera chirwere cheshuga chinotanga kuonekwa sechirwere chechirwere cheshuga uye chinopindura kumuromo wemishonga yechirwere cheshuga. Zvisinei, mumakore mashomanana, mishonga iyi inorasikirwa nekubudirira kwayo uye varwere vanofanira kutanga kushandisa insulini. Ichi chimiro chechirwere cheshuga dzimwe nguva chinonzi latent autoimmune chirwere cheshuga chevanhu vakuru (LADA), iyo dzimwe nguva inonziwo "mukati-kati chechirwere cheshuga" kana kuti chirwere cheshuga cheshuga nokuti inotanga sechirwere cheshuga 2 isati yava yechirwere cheshuga 1 chirwere cheshuga .
Vanhu vane LADA vane mazinga akakwirira eCIA neGADA, pamwe chete nemazinga akakwirira evanhu vasina kushandiswa nemaantiantibodies.
Nokufamba kwenguva, autoantibodies inowedzera zvirwere, zvichiparadza kukwanisa kwemuviri kubereka insulini. Kana izvi zvikaitika, shandisa chirwere cheshuga chepiri chirwere cheshuga.
Nyanzvi dzinofunga kuti nokuti vanhu vane LADA vane mazinga akawanda ekushanda zvakanaka, zvirwere zvavo zvemasimba zvinokwanisa kudzivirira ma autoantibodies zvakanyanya uye kwenguva yakareba kupfuura vanhu avo vaimbove vane chirwere cheshuga chechirwere chepabonde vari vaduku. Zvisinei, nekufamba kwenguva, autoantibodies yevanhu vane LADA vanoparadza simba remuviri yekubudisa insulini. Nokudaro, kuvimba kwe-insulin kunowedzera nokukurumidza mune murwere weLADA kupfuura kune inowanzoita chirwere cheshuga cheshuga.
Zvinofanira kuonekwa kuti vamwe vanhu vangave nemhando mbiri idzi idzi dzisingabatsiri autoantibodies uye asi havasati vava nehutano hwechirwere cheshuga. Mukuwedzera, zvakakosha kuyeuka kuti inonyanya kukosha zvinhu zvechirwere cheshuga - chirwere uye uremu-hazvina chokuita nekushaya simba kwezvirwere zvemuviri, uye izvi zvinogona kudzorwa nemararamiro akanaka.