M-proteinini is antibody-kana chikamu chechirwere-chinogona kuratidza mukuedzwa kweropa rako uye / kana urini, uye kuvapo kwayo kunogona kureva zvinhu zvakasiyana. Mune mishonga yeropa yakadai sa myeloma , 'M' mu 'M protini' inomirira monoclonal. A prototype monoclonal inobudiswa neasina kuchena, kenza kana kuti precancerous cells. Iko kunonzi monoclonal protein nokuti pane clone imwe chete, mono-clone ye "zvakafanana-mapatya emukenza," yose ichiita protein.
Mepuroteni yeM ino yakafanana nechigadzirwa chakakosha, kubudisa-mashizha; haina kurwisana nehutachiona uye harina kushandisa chaiyo.
Mumufananidzo, ye-Y yakasikwa yakagadzirwa bluu, kana kuti immunoglobulin, inonzi M protein.
Chinhu chikuru chakakomberedzwa shure kwacho isero rema plasma, iro rinoita zvirwere. Haasi yose maProtein M ane masimba anoramba akafanana neaya akaratidzwa. Dzimwe nguva, protein yeM myeloma inongova imwechete yeAn antibody.
Zvimwe Zvinyorwa zveM protein
Muchirevo chemuti we myeloma, M protini inoreva kushandiswa kwechimiro chemaviri eplasma yako inogadzira antibody. Zvinosuruvarisa, "Mprotini" inogona kutakura zvinoreva zvakasiyana-siyana mumishonga, zvichienderana nehurukuro kana chirwere chinenge chataurwa.
Mepuroteni yeM inogonawo kutsanangurwa kushandiswa kwemashoko anotevera:
- Monoclonal protein
- Myeloma protein
- Free immunoglobulin light chain
- Paraproteins
- Bence Jones mapuroteni
- The M spike
- I M-chikamu
Muchikamu chino, tiri kutaura zvikuru pamusoro peProteinine yeM inoratidzika nekenza-uye, kunyanya, kune mamwe marudzi ekenza yeropa uye inonzwisisika yemamiriro eropa neropa remafuta.
Zvisinei, mamwe anozivikanwa M mapuroteni anoitika mumishonga, kunyanya panyaya dzezvirwere zvinotapukira sezvinoratidzwa pano:
- Mprotini inogona kumira nokuda kwepirat matrix proteine seyomuProtini yeM1 yevirwere yeHIV .
- Mprotini inogona kushandiswa mukureva bhakitiriya chaiyo, streptococcus pyogenes.
- M protini, kana kuti "protein M," inobatsira kubhakitiriya mycoplasma genitalia .
Blood Cancer
Yese anti-antibody protein inonzi immunoglobulins. Muprotini yeM is immunoglobulin-kana chikamu chemunoglobulin-iyo inorondedzerwa se monoclonal, zvinoreva kuti inogadzirwa nekamwechete yemasero akaoma. Hazvisi zvomuzvarirwo kuti muviri uve nemakopi akawanda eeproteni imwechete iyo yakawanda inowanikwa mu myeloma, uye izvi zvakadzama zvinowanikwa muongororo yekuongorora. Inogonawo kukonzera matambudziko mumuviri, kunyanya kana mazinga achikwirira.
Kwainobva
Mune multipleel myeloma, protein yeM ino inobva kuwandisa kukuru kwemasero eplasma. Kazhinji, masero eplasma achabereka zvirwere zvakasiyana-siyana zvezvirwere. Muhutano hwakanaka kana hutano hwakanaka, huwandu hwemasero epa plasma anokwanisa kubudisa zvakasiyana-siyana zvezvirwere zvakasiyana-siyana zvinonzi mapyclonal antibodies, kana polyclonal immunoglobulins. Apo masero eplasma anova kenza, kazhinji pane imwe chete, yakaipa kwazvo yero yakave yakasimudzira vazhinji vanofanana nemakona. Zvose zviduku zvinokonzera sero imwechete, uye zvinongogadzira mapuroteni ega ega. Sezvo pane zvakawanda zvemasero eplasma, zvichiwedzera zvisinganzwisisiki, vanoita zvakawanda zveprotein ye monoclonal. Kuwanda, kana spike, muhutano weproteiniti imwe chete, inogona kuonekwa muongororo yebazi.
Urongwa hweMonoclonal Antibodies
Anorikisi imwe neimwe inoumbwa nezvikamu zvina. Iko kune maketani maviri akareba mukati, uye maviri maketani maduku kune kunze. Mumufananidzo, unogona kuona serosi ye plasma ine an antibody uye mamwe akawanda mashomanana ekurwisa.
Zvisungo zvechiedza, kana zviduku, kunze kwemitsara mu "blue Y" iri mumufananidzo, inonziwo Bence Jones mapuroteni , kana kuti mahwendefa emunikirini emasikirini akasununguka . Munyaya iyi, inongova chiduku chiduku chechirwere chikuru. Apo puroteni ye M iri chikwata chakareruka, yakawanda zvishoma, chaizvoizvo, kuti inogona kupfuura nemutsvo uye kupinda mumuguta.
Saka, kana kuongororwa kweropa chete kunoitwa zviketani zvitsva zvinogona kushaikwa kubva pavanopinda mumuguta.
Kune rumwe rutivi, kana chirongwa chemukondombera M chiri yose immunoglobulin-guru guru Y riri mumufananidzo-zvino rinogona kuonekwa muropa sezvo rakakura kwazvo kuti risapfuure kumuguta. Uye nokuti mapurotini aya akachengeterwa, huwandu hwakawanda hweprotini yakadaro muinso hunogona kukonzera chirwere chepfungwa.
Kukosha
- Kuongororwa: Mprotheni inowanzowanika mune dzakawanda myeloma uye mamwe mimwe mitemo
- Kuora kwepoyo: Apo maProtein M akawandisa uye ane zvakawanda zvakakwana munyaya yezvakaipa kuti zvivhare zvikamu zvebasa zvepvo, izvi zvinogona kukonzera zvirwere zvepfungwa uye pakupedzisira mafungiro asina hanya.
- Zvichienderana nezviratidzo zvepuroteni yakavigwa, zvimwe zvinokuvadza zvinogona kuitika.
Ropa uye Marrow Mamiriro Ezvo Anowedzera MProtini
Mamiriro ezvinhu angaguma nehupamhi hwepamusoro pemaprotestine M pamubvunzo unoyerera unosanganisira:
- Myeloma - Urine test ichave yakakosha yeprotini muM 50 kusvika ku80% yevanhu vane myeloma.
- MGUS - Monoclonal gammopathy yekusarudzwa kusinganzwisisiki inogona kuva nenzvimbo yakakwirira.
- Waldenstrom's macroglobulinemia - Uyu mukenza, unosanganisira masero ayo anonyatsogadzirisa masero eplasma, angave ane yakakwirira yeprotini yepamusoro.
Mune zvimwe zviitiko, masero anokonzera M-protein ane zvakaipa, uye anogona kupinda mufupa, lymph nodes, chiropa, spleen, kana dzimwe nhengo. Iyi ndiyo mamiriro ezvinhu mune multiple myeloma, yoga plasmacytoma, uye Waldenström macroglobulinemia.
Mune dzimwe nguva, m-protein inobudiswa nediki, shoma, isati yanyangadza clone yemasero yakawedzerwa, uye izvi zvinokonzera zviratidzo. Iyi ndiyo mamiriro mu monoclonal gammopathy yekusarudzwa kusinganzwisisiki MGUS.
Shoko Rinobva
Mamiriro ezvinhu mazhinji anogona kukonzera monoclonal gammopathy, spike mune imwe proteine chigadzirwa; uye, kwete yese yezviitiko izvi vane kenza. Iwe unogona kuva nemapurotini M ane zvimwe zvinokonzera matambudziko, sezvinoita systemic lupus erythematosus, rheumatoid arthritis, uye psoriatic arthritis. Iwe unogona kuva nayo neHitpatitis C utachiona hwehutachiona uye HIV / AIDS. Iwe unogona kunyange kuva nayo newaini yakabva kuWelbrand, chirwere chisingawanzo kubuda ropa. Nokudaro, mumatambudziko akawanda, chikonzero cheprotini yeM inokosha kupfuura kungovapo kwekuwana uku.
Sources:
Leukemia uye Lymphoma Society. Kuziva. https://www.lls.org/disease-information/myeloma/diagnosis
Papanikolaou X, Rosenthal A, Dhodapkar M, et al. Purogiramu ye cytometry inotsanangurwa cytoplasmic immunoglobulin index ndiyo chirevo chikuru chekufambira mberi kweyeymptomatic monoclonal gammopathies kune multiple myeloma (subset analysis of SWOG S0120). Blood Cancer Journal. 2016; 6 (3): e410-.