Zvinokonzera Kufambira Mberi Bone Kugadzikana muKenza
Osteolytic lesions (inozivikanwawo seansteoclastic lesions) inzvimbo dzepfupa rinokuvadza apo pfupa rave rakagadzikana nekuda kwezvipembenene zvakadai seyeeloma uye kenza yemazamu. Zvipembenene pachavo zvinoratidzika semakomba maduku pane X-ray. Vanhu vanowanzoreva kwavari seine "chikafu-chikadyiwa" chitarisiko.
Kubudirira kwezvipembenene zve osteolytic kunogona kutungamirira mukurwadziwa, kumusana kwepaupa kusagadzikana, uye kuwedzerwa kwengozi yefupa kuputsika.
Kurapa kunowanzoshandisa kushandiswa kwemishonga yekudzivirira humwe hutema kurasikirwa uye remishonga inonzi radiation kugadzirisa marwadzo uye zvimwe zviratidzo zvinosanganiswa.
Zvinokonzera Osteolytic Lesions
Osteolytic lesions inoumba kana pane kusawirirana muhutano hwehupenyu hunonzi bone remodeling. Iyi ndiyo iyo masero matsana pamasaga anovhuniwa uye anotsiviwa nemitsva. Munguva dzedzimwe mhando dzekenza, yakafanana neyangueloma, izvi zvinogona kukanganiswa nekugadzirwa kwemasero matsva asingagoni kuchengetedza nekurasikirwa kwekare.
Panyaya ye myeloma zvakananga, kune zvikonzero zvakasiyana siyana nei izvi zvichiitika. Kune rumwe rudzi rwekamuri inonzi osteoblast iyo inokonzera kuvaka pfupa; imwe yacho inonzi osteoclast inosunungura zvinhu zvinoputsa bone sechikamu chegadziriro yekugadzirisa. Apo myeloma inopinda mapfupa emapfupa, inovhara maosteoblast apo ichikurudzira osteoclasts kuti iparadze masero kunyange nokukurumidza.
Ndezvipi zvinoguma zvikwata zvekuvhiringidzika apo sero yakagadzirwa kazhinji yakafanana neyeafah.
Mukuwedzera kune myelomas, chikonzero chinowanzokonzera maziso eesteolytic is cancer yepamastra (kanzira dzainge dzakapararira mberi kwechimbo chemuviri wepakutanga). Izvi zvinosanganisira zvirwere zvekenza zve prostate, utachiona, mapapu, hono, uye chifuva.
Zvipembenene zvinowanzowanikwa mumapfupa makuru, akadai sehenya, musana, pelvis, ribcage, uye mapfupa makuru emakumbo.
Migumisiro yeBhudha Inokuvadza muMyeloma
Osteolytic bone tsvina inogona kukonzera zviratidzo zvakasiyana pasinei nekenza pachayo. Pakati pavo:
- Kutambura kwepfupa kunowanzosviba uye kunogona kuva kwakaoma kwazvo, kazhinji kunowanikwa nehutano hwehutano nekurwadziwa kunokonzerwa nefupa kushandiswa
- Osteoporosis (kufambira mberi kuderera kwefupa)
- Kuparara kwechipatara kunokonzerwa nemapfupa akave asina simba nekenza
- Hypercalcemia yechipfupa mumapfupa ayo akavhuniwa nekenza kubudisa calcium yakawanda muropa. Izvo zvinogona kutungamirira mukushushikana, kurutsira, kusava nesimba, kuvhiringidzika, myalgia (kurwadziwa kwemisimba) uye arthralgia (marwadzo akabatana). Arrhythmia (inenge isina kufanana nemwoyo) isiriwo dambudziko rinowanzoti, kana risina kutorwa, rinogona kuuraya.
Kurapa Osteolytic Lesions
Osteolytic zilonda zvinoshandiswa nekubatanidzwa kwema-dose radiation uye bisphosphonates , kirasi yemishonga inowanzoshandiswa kune vanhu vane osteoporosis. Kupora (zoledronic acid) imwe mishonga inonyanya kushandiswa mukenza yekudzivirira kuipa kwepfupa zvironda.
Bisphosphonates inopiwa mukati-kati kwemavhiki mana. Zvimwe zvinosanganisa zvinosanganisira kuderedzwa kwepfungwa uye, zvisingawanzoitiki, osteonecrosis yejaya (apo pfupa rejaya rinotanga kuipa).
> Sources
- > Bhutani, M .; Turkbey, B ;; Tan, E ,; et al. "Bone marrow kusagadzikana uye mapfupa emapfupa ekutanga mune myeloma yakawanda uye inopfurikidza nezvirwere: Anotarisira kudzidza achishandisa kufungidzira kwakanaka uye morphologic." Leukemia & Lymphoma . 2015: 57 (5): 1114-21.
- > Rajkumar, S. "Myeloma nhasi: Dendase tsanangudzo uye kurapwa kunoitwa." American Journal of Hematology . 2016. 91 (1): 90-100.
- > Reagan, M .; Liaw, L .; Rosen, C ;; et al "Dynamic interplay pakati pemafu uye multiple myeloma: mafambiro ekutanga osteoblast." Bone . 2015; 75: 161-9.