Mune zvimwe, ACE inhibitors semusinopril chinokonzera kukwezva uye kurira.
Angiotensin-kuchinja enzyme inhibitors (ACE inhibitors) semasinopril, captopril uye enalapril mishonga inopesana nemishonga. ACE inhibitors inobatsira pakuderedza kushanda kweropa uye kazhinji inosarudza kune dzimwe nzira dzakadai se beta-blockers (funga propanolol). Kunyange zvakadaro, vamwe vanhu vari paACE inhibitors vanoita kushungurudzika kwakanyanya kunokonzera kana kugadzirisa-kugadzirisa-kutenderera kwechimiro chekusangana, muromo nerurimi (angioedema) iyo inoita kuti mishonga iyi iome kana kuti inouraya.
Chii Chinonzi ACE Inhibitors?
ACE inhibitor inovhara enzyme yakaita angiotensin inoshandura angiotensin I kusvika angiotensin II. Nokudzivisa iyi danho rinodiwa mune renin-angiotensin system , ACE inhibitor inogona kuderedza kushanda kweropa kuburikidza nevasoconstriction uye kuora mwoyo kwebasa reldysterone.
Aldosterone inonzi steroid hormone (mineralocorticoid) inogadzirwa neadrenal glands (zona glomerulosa), inogara pamusoro peitsvo dzako. Aldosterone inoronga kusvibiswa kwemuti neinso nephrons. Kunyanya, aldosterone inoshanda kusvitsa sodium nemvura mumutambo wako mukushandura potasium iyo yakanyanyiswa uye yakashambidzwa kunze. Nyaya, sezvinotaurwa nemitemo ye osmosis, yakachengetwa sodium uye mvura inowedzera kuwedzerwa kweropa.
Heano mimwe mienzaniso yeACE inhibitors:
- lisinopril
- captopril
- perindopril
- enalapril
- benazepril
- fosinopril
ACE inhibitors sezvinonzi lisinopril zvinoshandiswa kuporesa dambudziko rekuwedzera kwehutano kana kuwedzerwa kweropa uye zvinonyanya kushanda kune avo vane chirwere chisingaperi chepfungwa uye mwoyo kusakundikana.
ACE inhibitors inoshandiswawo mukurapa kwekurohwa, kuputika kwemoyo, kukanganisa kwemwoyo nekudzivirira ramangwana rezvemwoyo. Zvinofanira kuonekwa kuti nenzira yakawanda, ACE inhibitors-seimwe mimwe mishonga inopesana nehutachiona-haitombogadziri mukuderedza kushanda kweropa nekudzivirira kupfurikidza nekurova kwemoyo muAfrica America.
Kune chikamu chikuru, ACE inhibitors yakachengeteka uye inoregererwa zvakanaka. Kana zvakatorwa zvakanyanyisa, zvisinei, ACE inhibitor inokonzera kusakanganiswa kana kutyisa pasi ropa uye kunonoka mwoyo wako (bradycardia), zvakare. Apo munhu anoita chirwere chepasi chakanyanya chechipiri kusvika kuACE inhibitors, iyo ACE inhibitor inorega uye mvura inopihwa inopiwa kuti iunza zvinetso zvakare. (Makoshesi haawanzodi kubatsiridza ropa rekutanga.)
Kune avo vane utera husina kunaka kana kune avo vanotorawo NSAIDs (zvinodhaka zvakadai seA aspirin), ACE inhibitors inogonawo kukanganisa maitiro emuviri wako munyu unozoita hyperkalemia kana kuti yakawandisa potassium . Hyperkalemia yakaipa nokuti inotyisa mwoyo wako kurova uye inogona kukuuraya iwe. Mushure mokunge pakarepo kuguma kweACE inhibitor, yakadaro hyperkalemia inorapwa muchipatara ichishandisa zvinodhaka se calcium, insulini uye glucose nezvimwe zvakadaro.
ACE Inhibitors, Angioedema, uye Cough
Pasi pemamiriro ezvinhu akadai, angiotensin-kutendeuka-enzyme inoputsa bradykinin, murevereri anoputika anofungidzirwa kuti ndiye anokonzera kuora nokuoma kwekuwuruka kunoonekwa munenge 25 muzana yevaya vanotora lisinopril nevamwe ACE inhibitors. Kuita kwakadaro kwakanyanya kupararira muAfrica vanhu vevanhu
Mune avo vanovandudza angioedema, zvinokonzerwa ne-type reaction, iyo ACE inhibitor inobva yanyangarika uye steroid uye diphenhydramine (Benadryl) inopiwa kupa kudzora. Kunyunyisa kwakadai kunogona kunge kuine chirwere chekukurumidzira nokuti chinogona kudzivisa nzira yako yepamhepo uye inogona kuitika chero nguva paACE inhibitors. Mune mamwe mazwi, unogona kutora ACE inhibitors kwenguva yakati usati watanga angioedema.
Chifukidzi chinokonzerwa neACE inhibitors hachifaniri kurapwa kunze kwekuregererwa kwechirwere. ACE inhibitors vane hafu yehupenyu hushoma uye huwandu hwehuwandu hwekuparidzirwa uye inofanira kushambidza mukati mako mukati mezuva.
Kana iwe kana munhu waunoda ari kutora ACE inhibitor seye lisinopril uye achiona chifuva, tapota ita nguva yekuona chiremba wako kuti aongorore. Chiremba wako angangodaro akarega ACE inhibitor uye atange iwe pane imwe mishonga inopesana nemvura yakadai seAARB (angiotensin II receptor blocker).
Kana iwe kana munhu waunoda achiona angioedema uye kutyisa kwehupenyu panguva yeACE inhibitor, usatorazve mamwe mishonga uye pakarepo itaidza 911. Pashure pokurapwa ne steroids naBenadryl, chiremba wako anogona kukuongorora uye anokupa iwe mumwe mushonga wehutano hwehutano . Ndapota cherechedza kuti mishonga iyi zvichida haisi kuzova ARB nokuti ARBs dzave dzichizivikanwa kuti haigoni kuita kuti angioedema, zvakare.
Pamashoko ekupedzisira, mamwe maitiro akashata anokonzerwa neACE inhibitors sezvakaipa zvinotsika pasi poutsika yeropa uye metabolic derangement (hyperkalemia) kazhinji inokonzerwa nekudarika, kurapa (NSAID) kushanda kana kuora mwoyo zvakakomba zvepfungwa zvinoshandura kusununguka. Nokudaro, paunenge uchitora ACE inhibitors, iva nechokwadi chokuti unogara uchitarisa ropa rako, kutevera pamwe nachiremba wako uye taura nachiremba wako kana iwe uchingonzwa uchinetseka, uine musoro wakachena, unozununguka kana zvimwe zvakadaro.
Sources
Atkins G, Rahman M, Wright JT, Jr. Chitsauko 70. Kuziva nekurapa kweHypertension. Mu: Fuster V, Walsh RA, Harrington RA. eds. Hurst's The Heart, 13e . New York, NY: McGraw-Hill; 2011. Yakasvika musi waApril 18, 2015.
Hayashi SA. Chitsauko 10. Angiotensin Blockers uye ACE Inhibitors. Mu: Olson KR. eds. Kutyisa uye Kuwedzerwa Kwemishonga, 6e . New York, NY: McGraw-Hill; 2012. Yakasvika musi waApril 18, 2015.