Mishonga Inotapura Mishonga Inoratidzira Chipikirwa Mukurapa Hyperkalemia
Imwe mishonga inonzi Patiromer yakaratidza chivimbiso mukurapa hyperkalemia kune vanhu vari kutora renin-angiotensin-aldosterone system (RAAS) inhibitors. Hyperkalemia inopisa upenyu uye inoguma nokushaya simba, inokwira kuora mitezo, kupera kupora, uye kusagadzikana kwepfungwa.
Dzimwe nguva, vanhu vanouya ne hyperkalemia, kana kuti mapeji akawedzera e potassium muropa, mumakiriniki ekunze.
Vanhu ava vakura uye vanowanzova nechirwere cheshuga chepfungwa uye varipo ne hyperkalemia mushure mekutora renin-angiotensin-aldosterone system (RAAS) inhibitors (β-blockers, angiotensin-kuchinja enzyme inhibitors, angiotensin receptor blockers [ARBs], uye aldosterone vapikisi vanopikisa) Mune varwere vakadaro vane nheyo yepamusoro yekushaya simba kana chirwere cheshuga nephropathy, potasium yezinga inogona kuwedzerwa kuva nengozi ine ngozi shure kwekutungamirirwa kwe RAAS inhibitors, iyo inongopedza potassium kubva kune imwe muurini.
Kazhinji, hyperkalemia chimwe chinhu chinowanzowedzera pakati pezvipatara varwere vanobatwa ne RAAS inhibitors nokuda kwekukundikana kwemoyo, chirwere cheshuga, uye chirwere chisingaperi chepfungwa. Chirwere cheshuga uye zvirwere zvisingaperi zvepfungwa zvinokonzera atherosclerosis uye glomerulosclerosis, zvichienderana; zvirongwa izvi zvinoshanda pamwe chete kudzivisa muviri (mafungiro) kukwanisa kubvisa potassium.
Kunyange zvazvo RAAS inhibitors iine potassium-kuvhara uye inogona kukonzera mazinga akakwirira e potassium kana hyperkalemia, kushaya mwoyo, chirwere chisingaperi chepfungwa uye chirwere cheshuga chinorapwa neRAS inhibitors. Nokudaro, zvingabatsira kuwana nzira inobatsira yekurapa hyperkalemia kune vanhu vane mamiriro ezvinhu aya vari kutora RAAS inhibitors.
Parizvino, hyperkalemia yakangorapwa chete nezviyero zvenguva pfupi zvakadai se beta agonists, calcium, kana insulini uye glucose, zvose zvinoshandisa potassium mumasero; loop kana thiazide diuretics, ayo ose ari potassium kuparadza uye kuwedzera mukana we potassium; mishonga inonzi sodium polystyrene sulfonate (Kayexalate), iyo inogona kukonzera hypomagnesemia, hypokalemia, dambudziko rekudzivirira kwemimba uye kunyange bowel necrosis; uye dialysis. Munguva yeChikamu chechitatu muchipatara, Patiromer inoderedza zvakanyanya potassium mazinga kune varwere vane chirwere cheshuga chepfungwa chinenge chiri kutora RAAS inhibitors uye yakagadzirirwa zvishoma kusvika kune yakanyanya hyperkalemia.
Patiromer yakagadzirwa nepolymmer iyo inopfuura nepamuviri wepamuviri isina kubviswa. Paanenge achipfuura nepamuviri wepamuviri, inomesa potassium. Mumakiriniki ekuedzwa, Patiromer yakaratidza kuti yakachengeteka uye inoshanda kwevhiki rose 52 kuvanhu vane hyperkalemia uye chirwere cheshuga, izvo zvinoratidza kuti iri kuvimbisa kugadzirisa kurapa. Mune mamwe mazwi, vanhu vanotora RAAS inhibitors vanogona kudzivisa hyperkalemia nokutora Patiromer. Uyezve, mushure mokunge vatori vechikamu vakamira kutora Patiromer, vakakurumidza kukura hyperkalemia zvakare. Pane imwe nhoroondo yakafanana, mune dzimwe dzidzo, Patiromer yakaratidzwa zvakare kudzivirira hyperkalemia kune vanhu vane mwoyo wakakundikana avo vakanga vachitora RAAS inhibitors.
Varwere vanotora Patiromer vakashuma zvimwe zvipingamupinyi zvinosanganisira kuipa kwezvirwere zvisingaperi zvepfungwa, hypomagnesemia, kuwedzera kwehuwandu hwehutachiona uye kushushikana kwepamuviri. Kakawanda, zvakadaro, 10 muzana chete yevatori vechikamu munharaunda iyi vakaramba kutora Patiromer nekuda kwemigumisiro iyi yakaipa.
Pasinei nechivimbiso chinoratidzwa naPatiromer munguva yeChikamu chechitatu chemakiriniki , dzimwe nyanzvi dzakataura nezvekunetseka pamusoro pemishonga. Chokutanga, nyanzvi idzi dzinotaura kuti ingadai iri pfungwa yakanaka yekuenderera mberi kuongororwa kwePatiromer kwenguva refu kupfuura gore - mushure mezvose, vamwe vanhu vachada kushandisa mari yavo yakasara paPatiromer pavanogamuchira RAAS inhibitors.
Chechipiri, hazvina kujeka kana vanhu vachitora RAAS inhibitors uye Patiromer ye hyperkalemia vanobatsirwa nekurapwa ne RAAS inhibitors sezvakafanana neavo vane nhengo dzakakwana dze potasium (normokalemia) vari kutora RAAS inhibitors.
Kana uine mibvunzo pamusoro pePatiromer kana chero mishonga, tapota ita nguva yekukurukurirana zvinhu izvi nechiremba wako. Ndapota yeuka kuti chiremba wako mutarisiri anonzwira tsitsi uyo anofanirwa kuedza kukubatsira kuramba uchiziva uye uchidzidziswa. Kuverenga nezvezvinodhaka uye kurapwa paInternet inzira yakanaka kwazvo yekuzvidzivirira iwe. Zvisinei, ruzivo urwu runofanira kubatsiridza kutarisira uye mazano anopiwa nechiremba wako.
> Sources:
> "Migumisiro yePatiromer paSerum Potassium Nhamba yevarwere ne Hyperkalemia uye Diabhesi Dhiyo Dendaase AMETHYST-DN Randomized Clinical Trial" naB GL Bakris nevanyori vanyori vakabudiswa muna JAMA muna 2015.
> "Kuchengetedzwa kweHyperkalemia Kubva" Hyper K + "Kurwisana Kuenda Kumusha?" neWC Winklemayer yakabudiswa muJAMA muna 2015.