Imwe nzira ye triptans, asi migumisiro inogona kunge ichidzivirira
Migraines inoenderera mberi ichiramba ichingopedzisira iine hutachiona hwehutano-kunyange nekutumirwa kwe triptans , iyo inoshandiswa mishonga inoshandiswa kubvisa kusinganisa-kusvika-yakaoma migraine kurwisa.
Dambudziko ne triptans nderokuti haisi nguva dzose inoshanda kuvanhu-inopfuura 35 muzana, maererano neshoko rezvesayenzi. Uyewo, dzimwe nguva vanhu vanovadzivirira pamusana pemagumisiro asina kunaka, sechifu chechisimba, huro nehuturu hwekunzwa, uye kushaya simba uye kunetseka.
Saka, kune imwe nzira yokutora triptan kune migraine here? Ikoko kunogona kuva nemumwe pakatarisana uye inonzi lasmiditan. Kungofanana nemishonga chero ipi zvayo, kunyange zvakadaro, lasmiditan zvakare inogona kunge iine zvimwe zvishoma zvinoda kuongororwa nevatsvakurudzi.
Kunyange zvakadaro, kudzidza nezvenyaya iyi anti anti-migraine zvinodhaka ndezvaunofarira zvikuru sezvo zvingaita sarudzo yakakodzera kwauri mune ramangwana. Uyezve, kana zvichibudirira, chirwere chinogona kupa ruzivo rwakawedzerwa pamusoro pehupenyu shure kwekurwisa migraine . Uye, kunyanya zvakanyanya, inogona kutsigira maonero emhando yeigraine yakabva asi inopesana nemafungiro epamusoro ekutora migraine.
Is Lasmiditan Yakachengeteka uye Inobudirira Here?
Kusvika ikozvino, kune zvikamu zviviri zvechikamu chekuedza kwechipiri:
Dzidzai
Maererano nenharaunda yakasarudzwa, nzvimbo inotungamirirwa ne-placebo-controlled control II muLancet, chirwere chinoratidzika sechinobudirira pakurapa zvakaoma-kusvika-zvakaoma migraines. Muchidzidzo ichi, vatori vechikamu vakashandurwa kuti vagamuchire mapiritsi e-placebo kana mapiritsi e-lasmiditan emhando dzakasiyana (50mg, 100mg, 200mg, uye 400mg).
Mhinduro yakaratidza kuti nhengo dzose dzakashata dzakagadzirisa zvakanyanya maitiro edzimusoro (zvinotsanangurwa sekuderedza kuwandisa kana kuoma kurwadziwa kwemigraine kusvika kumeso kana kurwadziwa) mumaawa maviri mushure mokunge misoro inotanga, zvichienzaniswa ne placebo.
Kunyange zvazvo ichivimbisa sechirwere chinoshanda, kukanganisa kwemishonga inogona kunge yakagadzikana nemigumisiro yechirwere, iyo vamwe vatori vechikamu vakaona yakasvibiswa neramiditan dose.
Iyi migumisiro yemigumisi yakaiswa:
Chizutu
Kuneta
Vertigo (manzwiro okusvinura)
Somnolence
Chidzidzo Chechipiri
Chimwe chikamu chechipiri chinodzidza muCefhalalgia chakaongorora kubata (IV) kutungamirirwa kweraimiditan, izvo zvinoreva kuti yakapiwa kuburikidza nemuviri. Vatori vechikamu chekudzidza vakave nemusoro wepamusoro-uye-wakakomba musoro wegrasi uye vakagamuchira kana vana vaine chirwere chinonzi veymiditan kana chirwere chinonzi placebo muchipatara.
Mhinduro yakaratidza kuti pamusana wevarwere vane 20mg IV, kuponeswa kwepfungwa (kunotsanangurwa zvakare sekuderera mumarwadzo kune unyoro kana kuti pasina maawa maviri) yaiva 64 muzana uye yepa placebo yaiva 45 muzana.
Zvakaipa zvinokonzerwa nechezzinesi, paresthesia, uye kunzwa kusuruvara (kazhinji kacho chikwata) kwaiwanzoonekwa muboka ravarmiditan kupfuura boka re placebo (65 muzana vs. 43 muzana).
Zvidzidzo Zviviri Zvinorevei?
Zvose izvi zvidzidzo zvinoratidza kuti lasmiditan inoshandiswa mushonga unobatsira pakurapa migraines yakaoma. Kunyange zvakadaro, zvidzidzo zvinounza nyaya dzinokanganisika pamusoro pemigumisiro. Chirongwa chikuru chechipiri III chinodiwa kuti chibvise zvirwere izvi zvinokonzerwa nematambudziko sezvo izvi zvingave zviri kukanganisa zvinhu zvekushandiswa kwemugumo.
Izvo Lasmiditan Works
Kufanana nemimwe mishonga inonzi migraine, iyo yakanyatsogadziriswa inoshandiswa pamashure mekuti mabasa ehurmiditan haana kunyatsojeka.
Izvozvo zvati, tinoziva kuti inobatsira dzimwe sarotonin receptors muuropi-uye muhuro hwemigraineurs, mazinga e serotonin ave akawanikwa achiderera.
Triptans , mishonga yemagariro inoshandiswa kubata mushonga wekuwedzera-kusvika-wakaoma migraines, uyewo anosunga serotonin receptors. Saka, sei lasmiditan yakasiyana kubva kune triptans? Nyanzvi dzinocherechedza kuti lasmiditan inonyanya kusarudza kupfuura triptans-iyo haisungiri kune serotonin receptors iyo, kana yakagadziriswa, inotungamirira kuropa remhepo inoputika (iyo inonzi triptans).
Kutaura zvazviri, chiitiko ichi chakaipa (chinonzi vasoconstriction) chinhu chakanyanya kukanganiswa kune triptans uye nei vachipikiswa kune vanhu vane nhoroondo ye:
- Chirwere chemoyo
- Stroke
- Peripheral vascular disease
- High blood pressure iyo isiri kudzorwa nemishonga
- Mimwe mhando dze migraines (somuenzaniso, hemiplegic migraine uye basilar migraine)
Uyezve, mune zvidzidzo zvemhuka, chirwere chakawanikwa chichivhara zviratidzo zvakabatanidzwa nemagetsi ekusimudzira kwechigarire chechigoni. Izvi zvinowirirana maererano nemitsva itsva pamusoro pe "nei" mushure mekumhanya kwemusoro, iyo inorwadza haisi iyo inokonzerwa neuropa mumvura inowedzera dzakapoteredza uropi, asi pane kushandiswa kwetsika dzepamusoro dzenzira.
Saka, chirwere chinotyisa chinokonzera chinetso chepamusoro-chinokonzera kurwadziwa kwemigraine kusiyana nemasumbu (ropa mudziyo) chinokonzera. Izvi zvinogona kutsanangura kuti nei triptans isingashandi kune vamwe migraineurs.
Mimwe Innovative Therapies
Icho chichiri kare kare kuti taura kuti lasmiditan ichafamba sei, asi zvishoma pane zvitsva zvitsva zvinobuda, uye vari kuchinja nzira yatinonzwisisa kuti migraines inokura sei. Semuenzaniso, kana hutachiona huchigadziriswa panguva yemigraine, zvinhu zvakadai se calcitonin peptide dzine chokuita nejeni (CGRP) dzinosunungurwa. Izvi, zvakare, kuwedzera midzi yeropa yakapoteredza uropi. Mishonga inodzivirira puroteni CGRP kana kuisunga nayo zvakananga kana kusunga kumubato wayo irikudziridzwa, uye zvidzidzo zvekutanga zvinopika.
Mukuwedzera, uye kunyange zvakanyanya kufadza zviyero (kwete mishonga) iyo inokurudzira dzimwe mitsipa, sezvakaita vagus nerve kana chirwere che supraorbital. Izvi zvinogona kuva sarudzo dzakanaka kune vanhu vasingakwanisi kutora kana kuvhiringidza ikozvino remuromo migraine zvinodhaka. Zvisinei, inogona kuva inodhura uye inishuwarenzi inogona kuve iyo nyaya.
Shoko Rinobva
Pasi pose, mufananidzo mukuru pano ndeyekuti lasmiditan yakaratidza kuti inoshanda muchikamu chechipiri chechipiri chekudzivirira kurwadziwa kwemvura. Asi, zvakakosha kuyeuka kuti zvidzidzo zvakadzama zvinodiwa ( chidzidzo chechikamu chechitatu ) kukonzera kunze kwehutachiona hwemigumisiro yechirwere sezvo izvi zvingave zvichigadzirisa zvinhu kune vamwe vanhu. Mashoko akanaka ndeokuti pane kunyora kana kuenderera mberi zvidzidzo zvechikamu chechitatu panguva ino.
> Sources:
> Aggarwal M, Puri V, Puri S. Serotonin uye CGRP muMigraine. Ann Neurosci . 2012 Apr; 19 (2): 88-94.
> Capi M et al. Lasmiditan yekurapa migraine. Nyanzvi Opin Investig Zvinodhaka . 2017 Feb; 26 (2): 227-34.
> Farkkila M et al. Kubudirira uye kushivirira kwemasimiditan, yemuromo 5-HT (1F) receptor agonist, nokuda kwekurapa kwakanyanya kwemigraine: chikamu chechipiri randomized-placebo-controlled, parallel-group, study-doing-study. Lancet Neurol. 2012 May; 11 (5): 405-13.
> Ferrari MD et al. Kunyatsorapwa kwemigraine nechisarudzo che-5-HT1F receptor agonist lasmiditan - maitiro anongoratidzwa-e-pfungwa yekuedzwa. Cephalalgia . 2010 Oct; 30 (10): 1170-8.
> Peer C Tfelt-Hansen, Olesen J. The 5-HT1F receptor agonist lasmiditan senzira yekurapa migraine kurwisa: kuongororwa kwenzvimbo mbiri-controlled controlled phase II. J Headache Pain . 2012 Jun; 13 (4): 271-75.