The Estrogen Connection
Waiziva here kuti kuva nemigraines kunogona kuderedza ngozi yako yekudzivirira kenza yepabonde mune ramangwana?
Kunyange zvazvo migraines uye kenza yemazamu yakawanda zvakasiyana-siyana mune zvehutano, pane chimwe chinhu chikuru chinobatanidza kana kuti chinobatanidza iwo - hormone yepabonde, estrogen.
Chirwere chepabonde uye Estrogen
Chirwere chepabonde chinoitika apo masero emukenza anogadziriswa anowedzera asingatauriki, kazhinji mumatope uye makirules emucheka.
Kuwedzera kwehupenyu hukuru kune estrogen kunowedzera mukana wako wekenza yepabonde. Saka chero chinhu chinowedzera isrogen mumuviri inogona kuwedzera kungozi yekenza yemazamu. Mienzaniso yemamiriro ezvinhu anowedzera isrogen anosanganisira:
- Nhamba yehupenyu kwenguva refu yekuenda kumwedzi (kutora mushure mezera remakore gumi nembiri, kuswedera kumwedzi mushure memakore makumi mashanu nemashanu)
- Postmenopausal kuneta, umo adipose kana mafuta mavara anoshandurwa ku estrogen
- Kusanganiswa kweHormone Therapy
Migraines uye Estrogen
Migraine chiitiko chinokasiyana nevakadzi vanobva pakuenda kwavo kumwedzi, mamiriro avo emurume, uye vane mimba. Iko kushanduka mumagraine frequency uye kusimba kungave kwakabatana nemadzimai ekuchinja kweserogen mazinga.
Somuenzaniso, migraine inowedzera nguva pfupi asati auya kana panguva yekuenda kumwedzi kwevakadzi ( kumwedzi kwemigraines ), apo herrogen mazinga akaderera. Kune rumwe rutivi, vakadzi vakawanda vanoona ruzivo rwemigraine yavo munguva yechipiri nechetatu mitatu yekudzivirira, nzvimbo yakakwirira yeestrogen.
Migraines uye Breast Cancer: A Controversial Connection
Vose migraines uye kenza yemazamu ndiyo isrogen inopindirana, kuitira kuti pangave nekubatana pakati pemigraine zviitiko uye mukana wakaderera wekuita kenza yemvere. Chimwe chezvidzidzo zvokutanga kuongorora hukama uhwu hwaiva muCancer Epidemiology, Biomarkers uye Kudzivirira.
Chidzidzo ichi chakawana kuti vakadzi vane self-reporting migraines vane 33 muzana vakatapudza dambudziko rekuwedzera hormone-receptor positive invasive ductal uye lobular carcinoma munyika ye postmenopausal. Chidzidzo chacho, zvisinei, hachina kutongesa kushandiswa kweNSAID , kirasi yakawanda yemishonga inoshandiswa kurapa migraines - uye zvidzidzo zvakasiyana-siyana zvakaratidza kuti kushandiswa kweNSAID kunogona kuisa kenza yepabonde yepamusoro.
Imwe yedzidzo mu Journal of Clinical Oncology yakawanawo kuti vakadzi ve postmenopausal vane self-reported migraines vaiva nehuwandu hwemucheche wekenza yemazamu. Ichi chidzidzo chakawana mamiriyoni 17 muzana mungozi wekukudziridza maitiro evanhu vane hutachiona hwema hormone-receptor. Kuwedzerwa izvi zvinopedzisira zvave zvichitarisira kushandiswa kweNSAID, pamwe nekushandisa doro uye caffeine, mbiri dzinowanzoita migraine .
Muna 2014, chimwe chidzidzo muCcercer Causes and Control chakaongorora mazana emakore mazana manomwe emakenza emucheche. Vatsvakurudzi vakawana kuti kana vachienzaniswa nevakadzi vasina nhoroondo migraines, vakadzi vane nhoroondo yakareba ye migraines (anopfuura makore makumi matatu) vane 60 muzana yega panjodzi yekudzivirira isrogen receptor positive ductal breast cancer.
Pamusoro pezvo, vakadzi vaiva nevana vavo vasati vava nemakore makumi maviri nemakumi maviri vakave nehutano hwekuvandudza isrogen receptor yakanaka yekenza yemazamu (zvose ductal uye lobular) zvichifananidzwa nevasiri-migraineurs (vakadzi).
Pakupedzisira, vakadzi vane migraine vane aura vangave vashoma (anenge nechetatu) kuti vawedzere chirwere chesaurogen chikafu chepachifu (zvose zvinokonzera ductal uye lobular).
Pamusoro pe flip parutivi rwekudzidza muna 2013 muCcercer Causes uye Kudzora vanopfuura 7 000 migraineurs havana kuwana hukama hunokosha pakati pemigraine uye njodzi yekenza yemazamu.
Zvechokwadi, zvese izvi zvidzidzo zvine zvisingakwanisi, uye kana zvakasarudzwa zvingave zvitsanangurira mhinduro dzavo dzakasiyana. Mufananidzo mukuru pano ndewekuti nyaya iyi neukama hunonakidza inofanira kuongororwa zvakanyatsotevera.
The Bottom Line
Yeuka, kubatana kunoreva unhu huripo kana sangano.
Hazvirevi kuti imwe chirwere chekurapa chinokonzera kana kudzivirira mumwe. Zvimwe zvidzidzo zvinoenderera mberi zvinoda kuongorora hukama hwakaoma pakati pekenza yebonde uye migraines.
Izvi Zvinorevei Kwandiri?
Ramba uchingoramba uchingoshanda muhutano hwako. Kurukurai mungozi yako yekenza yepese nechiremba wako. Ongorora kuti mararamiro ahutano, akadai sekurema, anogona kukuderedza migraine kutambura pamwe nehuwandu hwehutano hwepabonde.
Sources:
Dumitrescu R, Cotarla I. Kunzwisisa njodzi yekenza yemukaka: tinomirepi muna 2005? J Cell Mol Med 2005; 9: 208-21
Harris RE, Chlebowski RT, Jackson RD, et al. Chirwere chepabonde uye nonsteroidal anti-inflammatory drugs: zvinokonzerwa nemudzimai weAmai's Health Initiative. Cancer Res 2003; 63: 6096-101.
Li CI, Mathes RW, Bluhm EC, Caan B, Cavanagh MF, Chlebowski RT. Migraine nhoroondo uye kenza yepamuti yepamuviri pakati pevakadzi vemasmenopausal. J Clin Oncol . 2010 Feb 20; 28 (6): 1005-10.
Mathes RW et al. Migraine mumadzimai anonzi postmenopausal uye mungozi yekenza yemazamu isingaiti. Cancer Epidemiol Biomarkers Prev . 2008 17: 3116-3122.
Zuva reC AC, Rexrode KM, Lee IM, Buring JE, Tamimi RM, Kurth T. Migraine uye ngozi inotevera yekenza yemazamu: anotarisira boka rekubatana. Kanzera Inokonzera Kudzora . 2013 Jan; 24 (1): 81-9.