Pennsaid inyaya yeNSAID solution yakagamuchirwa neDAA musi waNovember 4, 2009, kurapa marwadzo uye zviratidzo zvine chokuita nemabvi osteoarthritis . Zita rechiito rePennsaid ndiro diclofenac sodium. Pennsaid yakagadzirwa naNovo Research Inc. Iyi inongorongedzere ye diclofenac, inowanikwa sepiritsi.
Pennsaid Inoshanda Sei?
Zvose zvisiri-steroidal zvinopesana nezvinokonzera zvinodhaka (NSAIDs) zvinoshanda nenzira yakafanana.
Inhibit cyclooxygenase, iyo enzyme inokonzerwa nekugadzirwa kwe prostaglandin, iyo inoshandiswa mumakemikari nheyo yehutu hunopisa. Nokudzivisa iyo enzyme, NSAIDs inotungamirira kukura kwemazinga e prostaglandin uye nokudaro kuderera kwechidiki. Zvinosuruvarisa kuti, prostaglandin inoshanda mune mamwe mabasa emuviri, uye saka NSAID dzine zvimwe zvinosvibisa migumisiro. Zvinonzwisisika, prostaglandin inokosha mukugadzirwa kwemukasi wechirimu iyo inokosha pakudzivirira denga rekumatenga kubva kuasiti. NSAIDs, kuburikidza nekuderedza prostaglandin, zvichiita kuti kuora mwoyo kwechidziviriro ichi chidzivirire uye kunogona kutungamirira kumarwadzo emudumbu uye zvironda.
Dzidziso yekushandiswa kwemasvikiro NSAIDs ndeyokuti kushandiswa kwemukati kwechirwere kunotungamirira kukuderera kwekuvhiringidza, uye kuwirirana kunobatanidzwa mukurwadziwa panzvimbo yekushandiswa, asi mushonga hauzofi wakareba zvakakwana kuwedzerwa ropa kuti utungamirire kuvhu dzakadai sedumbu remaronda.
Ichokwadi, zvidzidzo zvakaratidza kuti nekushandiswa kwemashoko emaNSAID maitiro ehutachiona ezvinodhaka ndeye 5% chete yezvavari mukati memishonga apo mushonga wakashandiswa.
Migumisiro yakaipisisa Yakangofanana neAraal NSAIDs
Kushandiswa kwemashoko eNSAIDs mukurapa kwamabvi osteoarthritis inopa mikana yakakosha yekuchengetedza kwevamwe varwere.
Iyo nzira iri shure kwezvikomborero sezvinotsanangurwa pamusoro apa. Kurapa kwepanyika kunogona kunge yakachengeteka uye inonzwisisika kana ichifananidzwa nemashoko eNSAID emuromo.
Izvo zvinogona kuitika zviitiko zvakashata zvakadai sevonda , kubuda kweropa , uye njodzi dzomumwoyo zvichiripo asi zvisinganzwisisiki nemhando yepiritsi yemishonga iyi.
Nzira yakanyanya kufanana nayo inobatanidza nePennsaid inonyoroka kana kuti kutsamwa apo inoshandiswa.
Inoshanda here?
Kuongororwa kwechangobva kuitwa kunoitwa Cochrane Collaboration yakatarira zvidzidzo makumi matanhatu nemashanu zvakatsvaga kana NSAID dzezvemashoko dzinoshanda. Muchidimbu, mhinduro ndiyo hongu. Paunobatanidza data kubva pane zvese zvidzidzo, vanhu vanenge 75% vakawana ruzivo rwakawanda rwehutano hwemutsipa / huri pamwe chete (kuremekedzwa kukuru kunorondedzerwa sekuderera mumarwadzo nehafu) pavanoshandisa diclofenac, iyo inopesana nevanhu vanenge 50% akagamuchira placebo.
Sources:
Cochrane Review of Topical NSAIDs
> http://www.cochrane.org/CD007402/SYMPT_topical-non-steroidal-anti-inflammatory-drugs-for-acute-musculoskeletal-pain-in-adults
FDA Inobvumira Pennsaid. Drugs.com.
http://www.drugs.com/newdrugs/fda-approves-pennsaid-topical-solution-1758.html
Pennsaid. NUVO