Mishonga Yenguva refu Yokuita Mishonga yePasinsinson
Vatungamiri ve chirwere chePasinson hachisi kunze kwezvinetso zvayo. Iyo mishonga yevodopa / carbidopa (inozivikanwawo seSinemet) ichiri kutaridzirwa yegoridhe yakarongeka yepamusoro yemotokari zviratidzo zvechirwere ichi. Asi zvakapiwa chokwadi chokuti Sinemet iri nguva pfupi-kuita, pane nguva dzakasiyana pakati pemadhora apo zviratidzo zvinodzoka sezvo mishonga inodhaka inodonha. Uye sezvo chirwere ichi chichipfuurira, mishonga iyi inenge isinganyatsobudiriri pakuraira zviratidzo zvinokura.
Varwere vanoda kutora maitiro akawanda kakawanda mukuedza kudzivisa "nguva dzisina kuitika" apo mishonga yemishonga inopera.
Imwe nzira inobatsira inogona kunge iri kuumbwa kunosunungura levodopa / carbidopa zvishoma nezvishoma, zvichipa huwandu hwakanyanya hwemishonga uye kuderedza kuchinja kwezviratidzo. Izvi zvingareva zvishoma kudarika "nguva isina" yevarwere vaPasinson.
Iyo Inoshanda Sei
Rytary yakabvumirwa mukurapa chirwere chePasinson. Iyo yakawedzerwa-yakasunungurwa mumuromo wecopule yomu carbidopa / levodopa, mishonga inoshandiswa iyo yakashandiswa kwemakumi emakore iyo yakabva yasunungurwa fomu (inowanzozivikanwa nezita rokuti, Sinemet). Kusiyana neyakatangira, neRytary, zvose zviri pakarepo uye yakawedzerwa mazinga e carbidopa / levodopa inowanikwa muropa mushure mekuti imwe nhamba.
Kubvumirwa kwechirwere ichi kwakauya pashure pemigumisiro yemakirini maviri emakiriniki makuru. Yokutanga, APEX-PD yakanga yakanyatsogadziridzwa (randomized, double-blinded, placebo-controlled) apo 381 varwere vane chirwere chepakutanga chaPasinson vakagamuchira imwe yezvikamu zvitatu zvakatarwa zvechirwere kana placebo kwevhiki makumi matatu.
Migumisiro yakaratidza kuvandudza mune zvose zvigadzirwa zvemotokari, basa rehupenyu hwezuva nezuva uye hupenyu hwemagumo eupenyu.
Kusiyanisa kubva pakudzidza kokutanga, muedzo wechipiri wemakiriniki, ADVANCE-PD yakanyoresa vanhu vane zvirwere zvakakura zvakasangana nekuchinja kwemotokari kana "nguva isina." 393 varwere vakashandurwa kuti vawane rimwe reRytary kana kuti pakarepo-release carbidopa-levodopa, kurapwa kwavo kwepamusoro.
Vaya vanogamuchira mishonga mitsva vakanga vasina "nguva," zvichiita kuti vawedzere "nenguva" pasina dyskinesias vachienzaniswa nevaya vanowana mishonga yavo yakasununguka-yakasununguka.
Chii Chinoita Kuti Nyuchi Dzakanaka?
Rytary haisi yekutanga yakasunungurwa-kusunungurwa kugadzirira. Stalevo (iyo ine levodopa, carbidopa, uye entacapone) yave iri pamusika kubva uye inoshanda chaizvo kune vateereri vakawanda. Chii chinoita kuti chimiro chitsva ichi chive nani?
"Chibvumirano che FDA chaY RYTARY (chinonzi rye-TAR-ee) chiitiko chitsva chinokosha pakurapa chirwere chePasinson uye chinopa kubudiswa-carbidopa-levodopa chigadzirwa chinobata chirwere cheParkinson," akadaro Fred Wilkinson, purezidhendi uye CEO, Impax Laboratories. "RYATARY yakagadzirirwa kutarisa chimwe chezvinhu zvinonyanya kukosha kune avo vanorarama nechirwere chePalinson, chinoita kuti kuderedza nguva yakawanda panguva iyo zviratidzo zvavo zvisingakwanisi kudzorwa."
Kunyange zvazvo kwete chirwere chatinenge tichimirira, Rytary inopa imwezve mishonga mumakiriniki mabhuku. Chiremba wako achakwanisa kuziva kana kana zvisina kukodzera kuishandisa mukutarisira chirwere chako kana kuti mamwe mishonga ichapa mhinduro dzakanaka.
Sources:
Beck, James, MD. "Vhidhiyo: FDA Inobvumira RYTARY &." Vhidhiyo: FDA Inobvumira RYTARY & . Parkinson's Disease Foundation, 08 Jan. 2015. Webhu.
"Impax Pharmaceuticals Inozivisa FDA Kugamuchirwa kwa RYTARY ™ (Carbidopa naLevodopa) Kuwedzerwa-Kusunungura Capsules Kurapa Kwezvirwere zvePasinson." Impax Pharmaceuticals Inopa FDA Kubvumirwa kwa RYTARY ™ (Carbidopa naLevodopa) Yakadziridzwa-Yakasunungurwa Capsules ... Impax Laboratories Inc., 08 Jan. 2015. Webhu.