Batsiro uye Migumisiro Yechechi
Hydroxyzine ndiro chizvarwa chokutanga, achigara antihistamine , izvo zvinoreva kuti ine madhara akafanana neBenadryl . Inotengeswa pasi pemazita ezita Atarax uye Vistaril asi inowanikawo muhuwandu hwemagetsi. Hydroxyzine yakatanga kusimbiswa sekunyengedzera mukati me1950 asi yakawanikwa iine antihistamine yakakura.
Hydroxyzine for Allergy
Hydroxyzine inowanzonyatsorongerwa kuti kurapwa kwezvinhu zvakasiyana-siyana zvinokonzerwa nevhu, kunyanya mikoko , asiwo inowanzoshandiswa pakurapa, kushungurudzika, kusuruvara, pamwe nekunyunyuta uye kurutsira.
Chirwere che hydroxyzine chinoenderana nemamiriro ekurapwa, kunyange zvazvo chirwere chakajairika chiri mapurogiramu 25 kusvika ku50 maawa matanhatu. Hydroxyzine inoshandiswawo kuvana, kunyange zvazvo chirwere chacho chinoverengerwa zvichienderana nekukura kwevana. Zvisinei, migumisiro ye sedation uye kurara zvinogona kutungamirira kune mishonga yeimwe yechipiri-antihistamine yechizvarwa seyakadai seXyzal (levocetirizine.)
Iyo Hydroxyzine Inoshanda Sei Nezvokurapa
Hydroxyzine inoshanda nekuvhara H1 receptor, kusunga kwavari nekuderedza basa re histamine. Histamine inobvumira huwandu hwemvura kutiza kubva kumapapuriri kupinda mumasumbu, uye izvi ndizvo zvinowanzoitika semhuno unopisa uye maziso paunenge uchitarisa. Histamine inobatsirawo kudzima uye kugadzirwa kwemakumbo mumashes.
Nokudzivirira H1 receptor, hydroxyzine inoshanda kuburikidza nehutano hwezvirwere. Izvi zvinogona kubatsirawo pakubata (pruritis) kunokonzerwa nehutachiona.
Asi hydroxyzine inopindawo muuropi apo ine zvimwe zvinokonzera kukonzera nekudengenyeka. Izvi zvinogona kunge zvisingadi kudiwa kana uchirapa mishonga.
Chechipiri-Generation Antihistamines Yakasikirwa neHydroxyzine
Iyo inoshandiswa metabolite ye hydroxyzine i- cetirizine (Zyrtec) , iyo inowanika pane-the-counter se-low-sedating antihistamine.
Iyo inoshevedza yeti cetirizine iyi yevovocetirizine (Xyzal) , iyo inowanikwa chete nemishonga uye yakatanga kuwanika muhuwandu hwemagetsi. Iyo haipindi muuropi sezvinoita sehydroxyzine, uye naizvozvo haibvumi izvochetezvo Iyo hainawo kubudisa zvinokonzera kushungurudzika kwehydroxyzine nokuda kwechikonzero chimwechete.
Zyrtec uye Xyzal vari nani pakurapa chirwere chinonzi allergenic rhinitis kupfuura hydroxyzine sezvo vane zvishoma zvinokonzera uye nguva yakareba yekuita. Izvo zvinoshandawo pakurapa ming'uchi uye kuchenesa.
Zyrtec naXyzal havakwanisi kurapwa nekuzvidya mwoyo, kusuruvara kana kushungurudzika, uye kurutsa, mamiriro ezvinhu ayo hydroxyzine kana imwe chizvarwa chekutanga antihistamine inogona kurongerwa. (Pasinei nehydroxyzine kuva nemakore makumi mashanu emishonga, ichiri kubatsira pakurapa kwehutano hwakasiyana-siyana.)
Kuongororwa kwezvidzidzo zve Xyzal (levocetirizine) muna 2009 zvakawana kuti 5 mg / d yakanga iri kubudirira mukuderedza zviratidzo zvemwaka weergenic rhinitis ( hay fever ,) perennial allergenic rhinitis, uye chronic idiopathic urticaria (chisingakoshi mikoko isina chikonzero chisingazivikanwi, kuvandudza unhu hwe hupenyu, nehuwandu hunogamuchirwa hunoenderana).
Pasi Pano paChipiri Chipiri vs First-Generation Antihistamines
Kubatsira kwechipiri chizvarwa antihistamines (Zyrtec naXyzal) ndiko kusakosha kwemigumisiro isingadiwi yakadai sedation, kugona, uye kuoma mukufungisisa nekudzidza.
Iyi migumisiro yechirwere inonyanya kukoshesa apo vechikoro-vana vane makore vanorapwa kwenguva refu ne hydroxyzine.
Xyzal (levocetirizine) ndiyo chete antihistamine ine zvisingabatsiri zvinokonzerwa nemakiriniki ekubudirira kwepanyama uye kwepfungwa mune vana vane makore matanhatu kusvika kune gumi nemaviri, maererano neongororo.
Izvozvo zvakati, hydroxyzine inoenderera mberi isingashandisi mishonga yekushandisa kurapwa kunyanya kunetseka, kusuruvara, uye kushungurudza uye kurutsa. Inogonawo kuva mishonga isingabhadharwi kwenguva pfupi kune vanhu vakuru vane utachiona kana migumisiro yechipfuva inogona kubatsira (zvakadai sokushaya hope kana kushungurudzika.)
> Sources:
> Pampura, A., Papadopoulos, N., Spicak, V., uye R. Kurzawa. Uchapupu hweKuchengetedzwa Kwechipatara, Kubudirira, uye Mubereki uye Muongorori Maonero eLevocetirizine ekurapa kwevana neAirgenic Disease. International Archives of Allergy uye Immunology . 2011. 155 (4): 367-78.