Beni-Jones mapuroteni ari zvidimbu zviduku zvirwere zvinoshandiswa zvinogona kuonekwa achishandisa urine test, kunyanya kuongorora uye kuongorora varwere vane myeloma yakawanda, rudzi rwekenza yeropa.
Multiel Myeloma
Multiple myeloma mhondi inoumba mumhando yeropa rega rega rinonzi plasma cell. Masero eplasma ndiwo masero anoita ma antibodies kuti akubatsire kurwisa zvirwere.
Kune chizvarwa chinowanzoshandiswa chemasera eplasma anobudisa-anti, inogona kutaura kuti zvakasiyana-siyana ibhizinesi ravo. Vanoita mapoka ose evanhu vanopesana nemaitiro.
Multiel myeloma ndechimwe chezvirwere zvakawanda zvinogona kubudisa "clone imwechete yema plasma masero." Funga nezvekanyoro kamwechete sechimwe chinhu chakafanana neboka remazana maviri akafanana. Iri boka revanhu harisi zvakasiyana. Nyeredzi imwe chete yemasero inowanzoita kuti iite anti-protein maitiro.
M-Proteins
Mukukurukurirana nezveBence-Jones mapuroteni, mamwe mazwi akawanda anowanzoshandiswa, akadai se myeloma protein, M-proteins, paraproteins, pasina immunoglobulin chain chain uye M-spike. Aya mazwi ose akafanana, asi haasi kurega kuchinja.
I 'M' muM-proteinini inomirira monoclonal, zvinoreva kuti kuunganidza kweprotein kunobva kune imwe koneti yemasero anokonzera anoripi-seni. Aya masero ose anogadzira zvirwere zvakafanana kana zvipembenene.
Zvitsva Zvitsva
Zvirwere zvekare zvinoshandiswa nemasayendisiti anonzi immunoglobulins - immune zvinoreva kuti vanorwisa zvirwere, uye globulin, zvinoreva kuti mapuroteni.
Izvozvo zvinowanzozivikanwa zvikuru, asi zvinosanganisira zvidimbu zviduku zvakaiswa pamwechete. Zvirwere zvakanyanya zvinoumba mapuroteni maduku akawanda, anonzi maketani ane simba uye maketani.
Mumufananidzo uri pamusoro apa, unogona kuona munhu wose anonzi antibody kana kuti immunoglobulin mberi, asi munhu wose anorifuta anoumbwa nezvikamu zvishomanana.
Zvikamu zvebhuruu ndizvo "zviketani zvakasimba" uye zvikamu zvegoridhe ndizvo "zviketani zvitsvuku." Mumufananidzo uyu, zviketani zvegoridhe zvinogona kuva Beni-Jones mapuroteni mumunhu ane myeloma yakawanda kana chimwe chiitiko.
Beni-Jones mapuroteni anonyanya kukosha kwezvidimbu zviduku zve an antibody (maketani emwenje) . Kuvapo kwemaketani emaketani muhuwandu hwakawanda mumuginha haisi chaiwo. Kazhinji, mumiririri wemuchina wepineti-chain chain anogona kuonekwa mumugini. Chiedza chemaketani mumuguta chinogona kukura nokuda kwezvikonzero zvakawanda zvakasiyana, zvisinei, uye kwete ose ari kenza.
Monoclonal Light Chains
Iye zvino, pane zvakaitika kuBence-Jones mapuroteni, zvinokosha kuyeuka kuti idzi maketani mashoma haasi chero akwegura ekare eketheni chechiedza - ndeye monoclonal light chain.
Beni-Jones mapuroteni, zvino, vari ...
- Monoclonal (inobva kune rimwe boka remasero)
- Monoclonal light chain (many copies of the same, small antibody-part)
- Yakawanikwa mumurini uye inosanganiswa nemhando dzakasiyana siyana, kusanganisira myeloma yakawanda.
Mamiriro ezvinhu
Beni-Jones mapuroteni mapepa akasiyana-siyana eM-protein, uye ivo vaduku zvakakwana kudarika mafiriro emuviri wenyu, itsvo. Izvi zvinoreva kuti, kana zviketani izvi zvisizvo zvikaitika muhuwandu, zvichapfuura kubva muropa rako kusvika mumuguta wako.
Pane mamiriro ezvinhu akawanda umo Bence Jones mapuroteni anogona kuwanika mumuti wemunhu, kusanganisira zvinotevera:
- Multiple myeloma - Multiple myeloma ikenza yeropa umo pane kuwedzera kweproducra dzemasero emu plasma - masero anobva kuB lymphocytes mumapfupa emapfupa. Masero eplasma ndiwo masero anoita ma antibodies anodzivirira kubva kune mamwe mavhesi uye mabhakitiriya. Pakati pe50 ne80% yevanhu vane myeloma vachave nemuedzo wekuvhenekera iyo yakanaka kune mapuroteni aya.
- Waldenström's macroglobulinemia - Waldenstrom's macroglobulinemia inowanzova nekenza inowanikwa mumasero eB (rudzi rwechichena chemuviri weropa). B masero anoenda kuburikidza nehutano kuti ave masero eplasma anogadzira antibody. Muchirwere ichi, kenza inowanikwa muB cell, isati yasvika pane iyo iyo inova sekija re plasma; saka, maWaldenström's macroglobulinemia akasiyana neyande myeloma, asi iyo mamiriro maviri aya, mune dzimwe, nzira dzakadaro, uye zvose zviri zviviri zvinogona kukonzera Beni-Jones mapuroteni.
- MGUS - MGUS inomirira monoclonal gammopathy yekusarudzwa kusinganzwisisiki. Ichi chirwere chinogona kuva chinyorwa che myeloma yakawanda uye chinosanganisira kuwedzera kwemazana emasero epa plasma, asi hapana chimwe chezviratidzo zvinosanganiswa neyengi myeloma.
Kukosha
Beni-Jones mapuroteni anowanikwa mune vanenge vaviri muvatatu vatatu vane myeloma yakawanda. Multiel myeloma ndiyo kenza yeropa inosanganisira kubudiswa kwakanyanya kwemasero e plasma. Kungofanana nekenza yemapapu ingave yakawandisa yemasero emumapenza asina kukwana, myeloma inosanganisira kuwedzera kwemasero eplasma.
Masero eplasma ndiwo masero anoita ma antibodies kuti atibatsire kurwisa zvirwere. Mamwe masero eplasma plasma, zvisinei, haaiti ma antibodies anobatsira kurwisa zvirwere, uye panzvimbo pacho, masero epurasma akawandisa anoita zvirwere zvakanyanya zvakasiyana zvakafanana.
Kuwedzerwa kwemamunoglobulin mumuviri kunogona kuva dambudziko kubva kune dzimwe nzvimbo dzakasiyana-siyana, imwe yadzo ndeye chirwere chepfungwa . Kazhinji, zvirwere zvekare zvinorema zvikuru kuti zvisasvibiswa kuburikidza ne tubules muitsvo. Beni-Jones mapuroteni madiki zvakakwana kuti apinde mauniti ekuchenesa muitsvo. Mutsvo, mapurotini aya anogona kuvaka nekukonzera zvinetso zvepvo. Mamwe maitiro emapurotini anowanzokonzera itsvo nenzira iyi kupfuura vamwe. Kunewo mamwe mimwe mitemo yekunyanyisa kwemaketani anokwanisa kukanganisa zvikamu zvakasiyana zvemuviri.
Kana wakamboonekwa kuti une chirwere chinokonzera kuwandisa kwemaketani emakineti emaproteni, chiremba wako angangokutsvaga nekuda kwematambudziko akafanana. Chimwe chezvinhu zvinogona kuitika nemaketani akareba zvakanyanya kunonzi amyloid chiedza-chain chain (amyloidosis), umo maketani emakona anouya pamwe chete uye anogadzira zvigadzirwa zvezvinhu zvinonzi amyloid, izvo zvinogona kukanganisa munhengo dzakasiyana-siyana.
Urine Test
Muedzo weBeni-Jones mapuroteni unosanganisira kuunganidza urini wako kwemaawa makumi maviri nemana kuti uongorore humwe hunoonekwa hweprotein. Beni-Jones mapuroteni anonzi Henry Bence Jones, chigadzirwa chemakemikari uyo akatanga kuwana zvinhu zvisingawanzozivikanwa zvezviyero izvi zvemuti mumakore ekuma1800. Kune mhando mbiri dzemaketani ekudzivirira - anonzi kappa uye lambda. Rudzi rwakajeka rweketani ruchena runogona kuva nehutoriki hunorehwa.
Shoko Rinobva
Kana iwe uchangobva kuongororwa, tora nguva yekudzidza nezvehosha yako uye kubvunza mibvunzo. Tsvaka rubatsiro kubva kune shamwari neshamwari dzako. Uye rambira pane tariro. Kurapa kwekenza yeropa kwakavandudzwa zvikuru mumakore achangobva kupfuura, uye mushonga mutsva ikozvino mukuongororwa kwekliniki.
> Sources:
> Basile U, Gulli F, Torti E, et al. Kuongorora kwekuongorora nzira yeBence Jones protein analysis. Chem Chem Lab Med. 2016; 54 (11): e331-e333.
> Cook L, Macdonald DHC. Kutungamirirwa kweparaproteinemia. Medical Journal Postgraduate . 2007; 83 (978): 217-223.
> Kyle, R., Larson, D., Therneau, T. et al. Clinical course of chain chain folding multiple myeloma (idiopathic Bence Jones proteinuria): retrospective cohort study. Lancet Hematology . 2014. 1 (1): e28-36.