Methimazole, Carbimazole naPropylthiouracil / PTU
Apo chirwere chetachiona chinowedzera kushanda - chirwere chinozivikanwa se hyperthyroidism - gland inobereka hormone yakawanda yekemikari. Izvi zvinogona kukonzera zviratidzo zvakasiyana-siyana, zvinosanganisira kukurumidza kukurumidza, kukonzerwa kweropa, kushushikana, kusuruvara, kudengenyeka, kuora muviri, chirwere, uye zviratidzo zvizhinji zvekushaya simba kwemetabolism, uye zvipembenene zvakanyanya uye nhengo.
Chirwere chikuru che hyperthyroidism chikamu chemishonga yemishonga inoridzirwa semishonga inonzi antithyroid. Antithyroid mishonga inonziwo thioamide. Idzo zvinodhaka zvinoshandiswa kurapa utachiona husina kupindira-hyperthyroidism - kusanganisira apo utachiona huri kunyanya kushanda semugumisiro weGeral's 'disease, toxic multinodular goiter, kana mishonga inopisa.
Zvinyorwa zveAitithyroid zvinoshanda nekudzivirira hutachiona hukwanisa kukwanisa kubudisa mahomoni maviri ehutori yakakura thyroxine (T4) uye triiodothyronine (T3).
Iyo mishonga yakakosha yevhitithyroid muUnited States inowanika methimazole uye propylthiouracil (PTU). Kunze kweUnited States, zvisarudzo zvinonzi methimazole, carbimazole, uye PTU.
Methimazole
Iyo mishonga inoshandiswa nevhidhiyo inonzi methimazole inoita kuti utachiona urege kushandisa iodine - kazhinji kubva pakudya kana kuwedzera - kubudisa utachiona hwehomori. Iyo imishonga inowanzoitwa kamwe kamwe pazuva nevarwere.
Methimazole dzimwe nguva anonzi nezita thiamazole.
Ichi chinodhaka chinoshandiswa munyika yose uye ndicho chirwere chetachivhiti chinonzi antithyroid chinoshandiswa muUnited States, iyo inowanikwa pasi pezita rezita rokuti Tapazole.
Vazhinji vanogadzirawo vanopawo maitiro evanhu vemashimazole.
Carbimazole
Carbimazole imishonga inoshandiswa, iyo inoshandiswa, inotendeuka kuva mishonga inonzi methimazole mumuviri, uye naizvozvo yakafanana zvakafanana mukuita.
Chinyorwa chinonyanya kuzivikanwa che carbimazole ndiNeomercazole.
Neomercazole inonzi trademarked zita re carbimazole uye inogadzirwa naAmdipharm International (UK). Mushonga wacho wakagamuchirwa muna 2004, uye unotengeswa muUnited States neEurope, asi hahuwaniki kana kuti inotarisirwa muUnited States. Iwe unogona kuona datasheet paNeomercazole pano. Heano mamwe maverengi mamwe mazano pamusoro peNeomercazole.
- Drug Maker Website: Amdipharm
- Kunyora Mashoko
Neomercazole Ingredients : carbimazole Ph.Eur; lactose; chikafu chechibage; sucrose; magnesium stearate; sucrose; talc; gum acacia; ferric oxide; propyl hydroxybenzoate; uye gelatin.
Inowanikwa Simba : 5 mg
Mamwe Mabhazi / Mazita: Carbimazole inowanikwa kune dzimwe nyika dzeEurope neAsia pasi pemazita ezita anotevera: Atirozidina, Basolest, CG1, Carbimazole Spofa, Carbotiroid, Mertiran, Neo-Mercazole, Neo-Thyreostat, Neo-Tireol, uye Tyrazol.
Propylthiouracil / PTU
Nzira iyo PTU inopedzisira yaita kuti utachiona huve nehutachiona hwehutori hwekuti utachiona hunoita kuti utachiona huve nehutachiona husati hwashandisa kushandisa iodini kuti utange utachiona hwehomoni. Inodzivisawo kutendeuka kwetachiona hormone T4 muT3. PTU ine nguva shomanana yekuita, saka varwere vanotora mishonga iyi kazhinji vanorayirwa kutora mishonga miviri kusvika katatu pazuva kuti iwedzere kutapisa mahomoni ehomori.
PTU ine mimwe migumisiro kupfuura iyo mimwe mishonga inokurukurwa pano, uye ndiyo inoshandiswa mishonga ye hyperthyroidism mune dzimwe mamiriro mashomanana (panguva yekudzivirira pamuviri, kuora kwehutachiona uye panguva iyo murwere ari kutarisana nemigumisiro yakakomba kubva kumashimazole).
MuUnited States, PTU chete inowanika; hapana mazita ezita re PTU rakatengeswa muUnited States. Nhamba yevashandi vanobudisa PTU.
More Information
Dzidza zvakawanda nezve hyperthyroidism nemishonga yaro, kusanganisira zvinodhaka zveva antithyroid, mune izvi zvinobatsira:
- Hyperthyroidism Risks / Symptoms Checklist
- Dambudziko reMakuva uye Hyperthyroidism
- Inowanzobvunzwa mibvunzo pamusoro peHyperthyroidism neMaronda 'Matenda
- Nzira 3 Dzokubata Hyperthyroidism
Sources:
Daily Med, US Food and Drug Administration Mishonga yeMishonga, Online
FDA Mishonga Yekuchengetedzwa Kwemishonga Kukurukurirana: Mutsva Wemabhokisi Matsva Kukuvadzwa kwakanyanya kwechiropa nepropylthiouracil, Kubvumbi 21, 2010, Online
Ross, Douglas MD, "Tsanangudzo yevarwere: mishonga yeAtithyroid," UpToDate . Yakagadziridzwa: November 13, 2009