Polycystic ovarian syndrome, kana kuti PCOS , inokonzera kuti mazamu emukadzi uye adrenal gland anowedzera uyerogens akawanda kupfuura ose, zvichiita kuti kuwedzerwa bvudzi, hutema uye zvisina kuitika nguva.
Kunyange zvazvo vatsvakurudzi vasina chokwadi chechikonzero chaicho chePCOS, inozivikanwa kuti kusaenzana kwegadziriro ye endocrine kunokonzera kuwanda kwekuchinja kunobatanidza nayo.
Zvisinei, hachiri kuzivikanwa chaicho chinokonzera izvozvo kuchinja.
Heino tarisiro pane zvinyorwa zvekutanga zvinofanirwa kuva kumashure kwePCOS:
The Hypothalamic-Pituitary-Ovarian Axis
Mahomoni ndiwo mapuroteni anokonzerwa nechimiro mukati memuviri chinokonzera kuchinja mukati memusero kana nhengo. IHypothalamic-Pituitary-Ovarian (HPO) inotsvaga is system yehomoni inodzora mukati memuviri.
Iyo hypothalamus inoratidzira mukati meuropi iyo, apo yakasimudzirwa, inobudisa hormone, inozivikanwa seGonadotropin-Releasing Hormone kana GnRH. GnRH inofamba ichienda kune chirwere chepituitary, chimwe chimiro chiduku muuropi. Plandish gland inobereka mamwe mahomoni akasiyana-siyana anotungamirira nekuchengetedza mabasa akawanda emitemo.
Nekukosha kune PCOS, pituitary inobereka FSH , kana Follicle Stimulating Hormone, uye LH , kana Lutenizing Hormone. LH inofamba ichienda kune ovary uko inokurudzira kugadzirwa kwe androgens .
Yakave yakanyatsofungidzirwa kuti zvinoramba zvichikwira kumusoro kweHL uye androgens, iyo inonzi testosterone, inokonzera PCOS.
Zvisinei, izvi hazvitsananguri kuti sei vakadzi vazhinji vane PCOS vasina hurefu hweHH.
The Insulin-Androgen Connection
Insulin yakambofungidzirwa kuti inobatanidzwa mukugadzirwa kweCPOS. Mukuwedzera pakuraira mazinga emushuga, insulini inokonzera chiropa kuti kuderedze kubudiswa kwemakemikari makuru anozivikanwa sebonde-hormone kusunga globulin, kana SHBG.
Testosterone inotorwa muropa neSBBG apo molecule iripo. Kana imwe shomanana yeSBB iripo, testosterone yakawanda isingawaniki (testosterone isiri kutorwa neSBBG) iri muropa. Inotendwawo kuti yakakwirira ye insulini inogona kuwedzera huwandu hwe androgens huri kubudisa.
Izviwo hazvitsanangurire zvizere PCOS, sezvo vakadzi vakawanda vane PCOS vasina insulin kushorwa , kuchinja kwokuti masero emitumbi anogadziriswa sei kune insulini, uye nyaya inowanzoonekwa muPCOS.
Genetics
Chimwe chinhu chinokosha ndiPCOS ndechokuti mumhanyi mumhuri. Vakadzi vane PCOS vanowanzova nehanzvadzi, amai, vakoma kana vanamume vanewo mamiriro ezvinhu. Kunyange zvazvo vanachiremba vasingazivi chikonzero chaicho chaicho, zvakajeka kuti zvine chokuita nekuzvarwa.
Zuva rimwe nerimwe vatsvakurudzi vanoswedera pedyo nekuziva maitiro ezvisikwa izvo zvingangodaro zvisiri izvo. Izvi zvakaoma nekuda kwekushayikwa kwechimwe chekuedza kuongororwa pamwe chete nebasa iro kunze kwezvinhu (zvakadai sokupisa, kudya uye kuita muviri) zvinogona kutamba mukukura kwechirwere.
Sources:
Harris, Colette uye Carey, Adam. PCOS: Bhuku reMukadzi Kutarisana nePolycystic Ovary Syndrome .Hhorson; London. 2000.
Thatcher, Samuel. PCOS: Dambudziko Rakavanzwa . Perspectives Press; Indianopolis. 2000.
Prapas N, Karkanaki A, Prapas I, Kalogiannidis I, Katsikis I, Panidis D. Genetics yePolycystic Ovary Syndrome. Hippokratia . 2009; 13 (4): 216-223.