Thiazolidinediones inonzi mishonga yemuromo inobatsira kuderedza shuga yeropa muchirwere chechirwere cheshuga . Mukuwedzera kune kudya kwakanaka uye kurovedza muviri, ndeimwe nzira yekudzivirira hutachiwana hweropa. Ivo vanozivikanwawo se glitazones.
MuAmerica, thiazolidinediones ikozvino inosanganisira Actos (pioglitazone), Avandia (rosiglitazone), pamwe nekubatana kwezvinodhaka Avandamet (rosiglitazone uye metformin).
Iyo FDA yakagadzirisa mitemo yemirairo paR rosiglitizone muna 2013 mushure mokupedzisa uchapupu hutsva hwakaratidza kuti hakuna kuwedzera kungozi yekurwisa mwoyo, asi kurambidzwa kunoramba kuripo muEurope.
Dos uye Dont
Thiazolidinediones inobatsira kuderedza insulin kudzivirira mumasero, kuvandudza nzira iyo muviri inopindura nayo ku insulin. Zvinowanzoitwa nemuromo kamwe kana kaviri zuva rega rega. Uyezve, inogona kushandiswa yoga, ine mamwe mapiritsi, kana kuti ne insulini. Thiazolidinediones haisi kutora insulin mumuviri kana kuti inoita kuti muviri uumbe insulini yakawedzerwa. Hazvirevi kutora chikafu chinopa utano chiremba anokurudzira kana.
Nhoroondo yekushandisa
Kubvira pakupera kwema1990, thiazolidinediones yakashandiswa kurapa rudzi rwechipiri chirwere cheshuga. Mushonga wekutanga mukirasi ino, Rezulin, wakabviswa pamusika weU.S. nekuda kwezvinetso zvisingawanzo asi zvakakomba zveropa. Mimwe nhoroondo dzakamutsa kushushikana pamusoro pengozi yakanyanya yekushaya mwoyo mune varwere vanotora Avandia.
Mamwe mimwe mitsara yakaratidza dambudziko rinowedzera rekurwadziwa kwemoyo ne thiazolidinediones, kunyange zvazvo hukama huripo husingarevi.
Iyo FDA yakaraira, muna 2006, kuti mazita emishonga eAvandia anonyevera nezvehuwandu hwekurwadziwa kwemoyo uye kurwadziwa kwepfupa kune vamwe varwere. Kushandisa Avandia kwakadonha zvakanyanya mushure mokunge nyevero dzekutanga dzakatangwa.
Muna 2010, FDA yakaisa mitemo mitsva yeAvandia kune vanhu vese vakange vasingakwanisi kudzora ropa ravo neropa rekushaya chirwere cheshuga kana vasina kukwanisa kutora Actos.
Muna 2013, migumisiro yechirwere chekemikari yeReCORD yakawana hapana kuwedzerwa kwekurwadziwa kwemoyo neAvandia (rosiglitazone). Somugumisiro, muna 2013 FDA yakasimudza mitemo inorondedzerwa yakaiswa kuAvandia. Musi waDecember 16, 2015, FDA yakabvisa kuongororwa kweNengozi nekudzivirira Dambudziko reRisiglitazone-ine mishonga, achigumisa kuti zvikomborero zvinopfuura zvengozi.
Kunyange zvakadaro, European Medicines Agency yakamisa kushambadzira kweRosiglitazone muna 2010 uye maFrench nemaGermany Agence Agents akasimudzirawo kushandisa pioglitazone (Actos) muna 2011.
Migumisiro Yechipfuva uye Ngozi
Migumisiro yakajairika inosanganisira kuwedzera kuwanda, zvirwere zvepamusoro zvinoputika, zvirwere zve sinus , misoro, uye anemia ane simba. Zvinokonzerwa nemigumisiro inosanganisira kuchengetedza kwemhepo, kukanganisa kwemwoyo, kuwedzera kuwanda, uye kurwadziwa kwepfungwa. Mimwe migumisiro inogona kusanganisira misoro yepamusoro, cholesterol yakakwirira, mapfupa asina simba, maziso eziso uye mikoko.
Nepo pasina huno huno huripo hunoratidza kuti Actos kana Avandia vanokonzera zvinetso zveropa, kuchenjera kuchengetedza maziso kune zviratidzo zvakadai sekunyunyutira, kurutsira, kurwadziwa mumimba, kuneta, kurasikirwa nechido, jaundice (kuchena kweganda nemeso), uye rima urinhi.
Ndiani Asingafaniri Kushandisa Thiazolidinediones
Vanhu vane chirwere cheshuga chechirwere chechirwere (vanoda nguva dzose insulin injections), mwoyo kusagadzikana, kana chirwere chechiropa haufaniri kushandisa thiazolidinediones. Vana uye vakadzi vane pamuviri kana vakwegura vanofanirawo kudzivisa kushandisa mishonga iyi. Vanhu vane matambudziko eziso kana mapfupa vanofanira kutaura nevanotarisira utano hwavo vasati vatora thiazolidinediones.
Zvimwe "Bvisa-Nyora" Zvishandiso
Actos inogona kubatsira mukurapa cholesterol yakakwirira. Thiazolidinediones inogonawo kubatsira kuwedzera ovulation uye kubereka mu polycystic ovary syndrome.
Zvimwe Zvimwe Kuziva Nezve Thiazolidinediones
Thiazolidinediones inofanira kutorwa zuva rimwe nerimwe.
Vanogona kutora mwedzi mitatu kuti vaite zvakakwana. Kana munhu akawana chero migumisiro yemigumisiro, kunyanya kuvepa, kukurumidza kuwandisa, kukurumidza kufema, mwoyo kupindira, kuchinja kumwedzi, kana mapfupa akaputsika, zivisa mutapi wehutano pakarepo.
Vanhu vane chirwere cheshuga, zvisinei, havafaniri kurega kutora mishonga yavo kunze kwekurayirirwa kuita saizvozvo. Zvakakosha kuona chiremba kunyatsotarisa kutarisa nekutora thiazolidinediones. Izvi zvinosanganisira kuongorora shuga yeropa, kuongorora kwebasa, uye kuedza kweziso.
Sources:
Mahaffey, Kenneth W .; Hafley, Gail; Dickerson, Sheila; Burns, Shana; Tourt-Uhlig, Sandra; White, Jennifer; Newby, L. Kristin; Asijda, Michel; McMurray, John; Bigelow, Robert; Musha, Firipi D .; Lopes, Renato D. (2013). "Zororo rekuongorora zvakare kwezvido zvepfungwa mumutambo RECORD". American Heart Journal 166 (2): 240-249.e1.
Drazen, MD, Jeffrey M., Stephen Morrissey, Ph.D., naGregory D. Curfman, MD "Rosiglitazone-Yakaramba Inetseka Nezvokuchengetedza." The New England Journal of Medicine. 357 (2007): 63-64.
FDA Mishonga Yekuchengetedzwa Kwemishonga Kukurukurirana: FDA inoda kubviswa kwezvimwe zvinorambidza uye zvinoparadzanisa mishonga yehusiglitazone ine diabetes. FDA Newsroom. 11/25/2013. US Food and Drug Administration.
David K. McCulloch, MD. "Thiazolidinediones mukurapa chirwere cheshuga mellitus," Dec. 17, 2015. UpToDate.