Iko kune kuwedzera kufarira mukushandiswa kwe nanotechnology uye kushandiswa kwemishonga mukurapa. Izvo zvisingaiti zvisinganzwisisiki zvisinganzwisisiki zvinoyera zviratidzo zvinokosha, pamwe chete nemashonga asingashandisi anoita kuti nzira dzive dzakanyatsonaka, ikozvino dzinoenda kune dzose. Imwe nzvimbo inokosha yekufambira mberi mune nanotechnology ndeyekugadzirwa kwe nanoparticles inogona kutakura mishonga uye inotarisa masero kana maviri.
Iyi nano "drones" inoshandiswa pakugadzira zvinhu ine simba guru munzvimbo dzakasiyana dzemishonga. Vakatotanga kuiswa mune inocology uye vanoshandiswa kuderedza turu-sekudzivirirwa mumagetsi. Muna 2015, chirwere chemwoyo chinoshandiswawo nanotechnology kuendesa zvinodhaka nekugadzirisa mishonga , kugadzira nzira yekurapa kutenda kweAristrosclerosis nenzira itsva, zvichidzivirira kudzivirira kwemoyo nekurova.
Kushandisa Nanotechnology Kugadzirisa Kurwisana
Chidzidzo chezvipfuwo, chakabudiswa muScience Translational Medicine , chakashuma kuti nano-sized drones inogona kushanda mukugadzirisa reherosclerotic plaque, zvichiita kuti chidimbu chacho chirambe chichigadzikana uye zvishoma zvishoma kuti zviputse uye zvigone kuva ropa rinouraya. Vanotsvakurudza kubva kuHarvard Medical School, Brigham nevakadzikadzi Hospital uye Columbia University yakagadzira nanomedicines yakagadzirirwa kutakura zvinhu zvinopesana nezvinokonzerwa zvakananga kune chinangwa chinangwa.
Kusagadzirisa kuputika ndicho chinhu chinokonzera kukura kwezvipembenene zve atherosclerotic.
Paakashandisa nano drones yaiva nemishonga yakagadzirwa kubva mumuviri wemaprotinini anorema kuporesa annexin A1, kuwedzerwa kukuru kwakagadziriswa mumakonzo ane hutachiona hwehutachiona hwehutano. Handizvo chete kuputika kwakaderedzwa, mitsetse yemakonzo yakagadziridzwawo, chikamu chekurapa kwakasiyana nedzimwe nzira itsva yerapi.
Kugadzirisa zvirwere zvinokonzerwa nemarayari zvinogona kuve zvakakosha pakudzivirira kwekurwadziwa kwemoyo uye zvinogonawo kudzivisa nhamba yevakafa inokonzerwa ne atherosclerosis, iyo ikozvino ndiyo inokonzera chirwere uye rufu muUnited States. Izvo zvave zvichinyatsofungidzirwa kuti nzira itsva iyo inofanira kunge ichangobva kugadziriswa uye yakaedzwa kuvanhu, ichipa nzira inonakidza yekurapa kuvhiringidza nekutarisirwa, kunzvimbo yekutengesa kwepeptidi.
Vatsvakurudzi veWeldon School of Biomedical Engineering, Purdue University, vakatsanangura imwe nzira yekubudirira mukurapwa kwekuputika uchishandisa nanotechnology. Vakagadzira collagen-inosunga nanoparticle system iyo inogona kushandiswa kurapa chirwere chetachiona chirwere. Iyi itsva nzira inoshandisa nanoparticles iyo inosungirwa ku collagen uye kusunungura pe-anti-inflammatory peptides. Iyi nanoparticles inogonawo kuderedza kuvhiringidza, uyewo kukurudzira kuvezve patsva kwezvakakuvara.
Epithelial Wound Kugadzirisa Na Nanoparticles
Kukuvara kugadzirisa ndeimwe nzvimbo yekurapa iyo nanoparticles inogona kushandiswa zvinobudirira kuita kuti pave nekuoma-kuoma kurapa. Giovanna Leoni nevamwe vashandi paYunivhesiti yeEmory vakashandisa nzira yekugadzira nanoparticles ine mapuroteni ezvinyorwa annexin A1 kune yakakuvadzwa mumumbosa mucosa.
Kukuvara kwemukatial kusingaperi kune humwe huzhinji hwehupfumi hwemamiriro ehutumbu, kusanganisira chironda chekurara uye Crohn's-conditions-iyo inobata inofungidzirwa inotaridzika mamiriyoni maAmerica. Kuongorora kwechangobva kuitika pamakonzo kwakaratidza kuti kuenderera mberi kwekuendesa zvinopesana nekuputika zvinhu kunowedzera kuporesa kwemavara akakuvara uye kunokurudzira epithelial wound repair. Muhurukuro yavo, yakabudiswa mu Journal of Clinical Investigation , vanyori vanoratidza kuti kuendeswa kwemunharaunda ye peptides yakaiswa mukati me nanoparticles kunogona kuva nzira itsva yekurapa kwevanhu vanotambura nehuputi hwechirwere chirwere (IBD).
Pakave kunewo kufarira mukuvandudzika kweanoparticles yemasikirwo inogona kubatsira kubata zvirwere zvakadai seBDD. A nanoparticle yakabva ginger yezvokudya yakashandiswa zvakanaka mukudzidza yakatungamirirwa naMingZheng Zhang weGeorgia State University, Atlanta. Natural nanoparticles inogona kuderedza zvinetso zvakabatanidzwa nekugadzirwa kwemakemikemikari.
Nanomesh Kupfeka Mavanga Asingaperi
Imwe nzira inogona kushandiswa yeanotechnology yakaratidzwa naMartina Abrigo pamwe neboka rake revatsvakurudzi veAustralia Swinburne University of Technology. Abrigo ari kuongorora kunze kwekushandiswa kwezvidiki zviduku kuti zvirape maronda ane chirwere chisingaperi. Akasika mesh kubva kune electrospun polystyrene fiber yakagadzirirwa kukwevera mabhakitiriya kubva muchironda. Iyo nanomesh inopa maitiro akanaka ekukura kwebhakitiriya akadai saStaplocloccus Aureus naEscherichia Coli , saka vanoswededzwa kune mesh, vachisiya varonda vachichena. Mabhakiteriya anopindura pamasere e-fiber akasiyana-siyana emadharita akaedzwa kuburikidza nekubatanidza kuongorora microscopy electron uye microscopy yakawanda.
Iyo mabhakitiriya ainyanya kufadzwa nemafuta aive akaenzana nekuenzana nawo. Mhinduro, yakabudiswa muAACS Applied Materials and Interfaces , inoratidza kuti electrospinning nanofibers inogona kunge iri nzira itsva yekudzivirira mavanga anotapurirwa nemaabhakitiriya anowanikwa. Kusvika ikozvino, masayendisiti ave achingoongorora majekitini uye kuongororwa kwezvigunwe-zvakagadzirirwa kuburikidza neganda. Zvisinei, zvinotarisirwa kuti munguva yemberi iri pedyo, kuedza kwakafanana kuchaitwa pazvipenyu zvinorarama kuti uongorore zvinogona kuitwa nenzira iyi itsva. Mu vivo zvidzidzo zvakatoitwa nemamwe mhando dze nanoparticle maonda ekugadzirisa, somuenzaniso, sirivha nanoparticles pamwe nekubudirira.
> Sources:
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> McMasters J, Panitch A. Nyaya yakareba yakakwana: Collagen-binding nanoparticles ye extracellular anti-inflammatory peptide delivery inoderedza kupera kweplatelet activation, kukurudzira kuguma kwekufamba, nekudzivisa kupisa. Acta Biomaterialia , 2017; 49: 78-88.
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