Saricylates Inotsanangurwa seNSAIDs
Kanyama-kutaura, salicylates ndiyo munyu kana ester ya salicylic acid. Vazhinji vedu tinoziva kuti aspirin inobva kuSalicylic acid. Aspirin inoshandiswa mumakemikari saacetylsalicylic acid. Saricylates yakakamurwa kuva mapoka maviri, acetylated uye asina kukwana. Apo aspirin inogadziriswa, mienzaniso yeasicetylated salicylates inosanganisira Disalcid (salsalate), Trilisate (choline magnesium trisalicylate), uye Pepto-Bismol (bismuth subsalicylate).
Chimwe, chinonzi Dolobid (diflunisal), hachiwanikwi muUnited States.
Maitiro aSalicyates Anoshandiswa Sei
Yakangoerekana yawanikwa mune zvimwe zvirimwa, zvakadai semuchena willow bark uye mashizha e wintergreen, salicylates vaitenda kuti vane chidziviriro chekuchengetedza zvipembenene uye zvirwere zvinomera. Muna 1860, salicylic acid yakange yakagadzirwa nemakemikari inoita kuti pave nekushandiswa kwakawanda. Mushonga, salicylic acid ine analgesic (kurwadziwa-kuneta), anti-inflammatory, uye anti-pyretic properties. Uye, nokuti inogona kubvisa marwadzo pamwe nekuderedza kupisa uye fever, salicylic acid yakaita seTrifecta yemishonga. Zvisinei, pamatazi anodiwa kuti apindure, salicylic acid inogona kukonzera matambudziko emagunha. Kana ikashandiswa muhomwe huru, yakakura kudarika iyo inorayirwa kugadzirwa kwerapa, salicylic acid inogona kuva inotyisa. Uyezve, vamwe vanhu vangave varigogi kune salicylic acid. Kunze kwekushandiswa kwaro mune remishonga, salicylates inoshandiswa muzvokuchengetedza zvekudya, mune zvinopesana, uye mune zvimwe zvinhu zvinobatsira kudzivirira kukura kwebhakitiriya, kuuraya fungus, uye kubvisa ganda rakafa (keratolytic, seKerasol).
Dumbu uye Mwoyo Mungozi Yakabatana naSalicylates
Kusiyana ne aspirin, iyo inhibisa platelet aggregation uye zvino inowedzera dambudziko rekubuda ropa, mishonga isina kukwana yakawanda ine zvishoma zvishoma pamagetsi. Somugumisiro, havakwanise kukonzera kubuda ropa kana kubuda ropa pamakiritsi anodiwa kuti kuderedza kupisa nekurwadziwa kweArthritis.
Kune rumwe rutivi, zvichienzaniswa nehana yakaderera aspirin, hakuna huongorori hunosimbisa kuti izvo zvisiri izvo zvinonzi salicylates zvinotapa mwoyo. Muzvokwadi, kufanana nedzimwe NSAID dzose dzose (nonsteroidal anti-inflammatory drugs) , kushandiswa kwavo kunogona kukonzera njodzi yakawanda yehutachiona hwehutachiona hwezviitiko, zvakadai sekurwadziwa kwemwoyo.
Maererano neRheumatologist, Scott J. Zashin, MD, "Zvichida kana kuti kwete high-dose aspirin yakafanana neyechirwere chepasi sezvo aspirin yakaderera isati yadzidzwa.Kuwedzera, kune ruzivo rwangu, hapana zvidzidzo zvakabudiswa zvakaenzanirana nekubudirira kana kuvhara kwepamuviri yeasicetylated salicylates uye COX-2 inhibitors . "
Zvidzidzo zvinogona kuwanikwa zvine chokuita nemariclates zvinowanzove zvakakura. Chimwe chidzidzo chakabudiswa mu Journal of Rheumatology chienzanisa nekubudirira kwe salsalate (saliclate isina kukwana) kune Voltaren (diclofenac) . Zvakagumiswa kuti salsalate uye diclofenac zvaive zvakaenzana uye kuti salsalate inogona kuonekwa seimwe nzira kune dzimwe NSAIDs.
Chimwe chidzidzo, icho chakabudiswawo mu Journal of Rheumatology, yakaratidza kushanda kwezera mu salicylate toxicity kuvanhu vakwegura vane rheumatoid arthritis . Pasinei nokutora chirwere chepasi chesa salicylates kupfuura boka duku revanhu vari muchidzidzo, boka revanhu vakwegura raibatanidza kuwedzera kuora.
Dr. Zashin akaenderera mberi achiti, "Kubva pane zvakaitika kwandiri, maNSAID ezvakanyorwa uye COX-2 inhibitors,, kazhinji, anoshanda zvakanyanyisa kugadzirisa marwadzo nekuputika kweArthritis. Izvo zvinonzi, kuedzwa kwe salicylate isina kukwana hakusi kwepfungwa pakusarudzwa varwere vane ngozi yakawanda yokubuda ropa kana kuti zvironda. "
Shoko Rinobva
Makumi emakore akapfuura, salicylic acid kana aspirin ndiyo yaishandiswa pakurapa marwadzo arthritis. Kuti zvaiita sokuti kuderedza kuputika kwaiva bhonasi panguva iyoyo. Iye zvino, kune mamiriyoni emishonga inoshandiswa. Kazhinji inofungidzirwa kuva yakachengeteka, uye isingabatsiri pakuenzanisa nemimwe mishonga, saricylates inosarudzwa iyo inofanira kufungwa navanachiremba nevarwere.
Zvinonzwisisika iwe iwe uye chiremba wako kuti uone nhoroondo yako yezvokurapa (semuenzaniso, ulcers, chirwere chemwoyo) paunosarudza pakati pezvinodhaka zvinodhaka.
> Sources:
> Bombardier C. et al. Salsalate, A Salicylate Yisina Kuchengetwa, Inoita Sokuita saDiclofenac muVachipatara NeRheumatoid Arthritis. Salsalate-Diclofenac Kudzidza Boka. Nyaya yeRheumatology. 1995. April; 22 (4): 617-24.
> Grigor RR et al. Salicylate Toxicity muvarwere vakwegura vane rheumatoid Arthritis. Nyaya yeRheumatology 1987. Feb; 14 (1): 60-66.
> Salicylates. Drugs.com.