Parizvino iwe unogona kunge uchiziva kuti mamwe mazamu anoita kuti vanhu vawane kenza. Kuparidzirwa kwevhidhiyo yakapoteredza Angelina Jolie's prophylactic mastectomies nemhaka ye "kenza yemazamu yemazamu" yakawedzera ruzivo rwevanhu. Zvitsva, uye zvidzidzo zvisinganyanyi kuzivikanwa zvakawana kuti kushanduka kwakasiyana mune imwe yemagetsi akafanana kunokonzera njodzi yekenza yemazamu kunogonawo kuwedzera mukana wekuva nekenza yemapapu.
Asati ataura kuti ndiani ari pangozi, zvakadaro, zvinobatsira kutsanangura mazwi mashoma.
Chii Chinokonzerwa Nesimba?
Kuberekwa neine gene gene mutation yakadai se BRCA2 hakureve kuti iwe uchawana kenza zvechokwadi. Pane kudaro, zvinoreva kuti iwe unobatwa nehupenyu hunoberekwa ( maitiro ezvakaberekwa ) kana huwandu hwekuwana chirwere chacho. Zvichienderana nezvinonzi gene gene mutation, njodzi yako inogona kusiyana zvikuru. Semuenzaniso, kushanduka kwemaitiro kunogona kureva kuti mikana yako yekukura nechirwere inenge 80 muzana kana inogona kunge iri duku.
Kazhinji yenguva, chikonzero chekenza chinonzi inonzi multitifactorial. Izvi zvinoreva kuti vazhinji (mazhinji) zvinhu zvinoshanda pamwechete kuti zvikonze kana kudzivirira kenza. Munyaya yemukenza wemapapu, izvi zvinogona kureva kusanganiswa kwekusvuta, kusvibiswa kwemweya, radon , kana hutano hunowedzera dambudziko rako, asi zvinhu zvakadai sokudya kwakanaka uye kurovedza muviri zvinogona kuderedza ngozi.
Chii chinonzi BRCA2 Gene Mutation uye Inokonzera Sei Kansa?
Zita regamutemo re BRCA2 gene ndiyo "kenza yebonde 2, kutanga kwekutanga" gene.
Kushanduka kwemajini kwakatanga kuwanikwa kuine kenza yemazamu, kunyanya kenza yemazamu muvakadzi vaduku.
Zvinyorwa zvinoshanda nekunyora mapuroteni mumuviri, zvakadai semagadzirirwo. Apo BRCA mazamu akachinjwa, mapuroteni asina kukodzera anoumbwa. I-BRCA2 geni inorudzi rwechirwere chinodzvinyirira gene .
Aya majee emagetsi emapuroteni ane basa rekugadzirisa DNA yakaodzwa (yakakuvadzwa semugumisiro wezvinhu zvinokonzerwa nezvoutachiona, mazaisai, kana zvikanganiso mukuzvidzivirira kwegene) kana kubvisa sero kuburikidza nekugadziriswa kwesero rinouraya kunonzi apoptosis. Pasina iko kugadziriswa (kana kubviswa kwesero kuburikidza ne apoptosis), kukanganisa kunobvumirwa kuenda kusina kuvharwa uye masero ane kenza anogona kukura.
Kunyange zvazvo mamwe maitiro echishanduko anokonzera puroteni imwe chete, BRCA2 nhete dzeproteinini inoshandisa mutsa wakafanana nemutungamiriri. Iro mutoro wekutungamirira zviito zvemajini akawanda anoverengeka kune mapuroteni ane basa rekugadzirisa DNA yakaora. Kuchinja kwemukati mu BRCA2 hakuzi zvakafanana, uye vatsvakurudzi vakawana marudzi anopfuura 800 ekuchinja.
Ndezvipi Zvakafanana Ndizvo Zvinochinja?
Zvinenge zviviri kubva muzana zvevanhu vekuberekwa kweEurope vanotakura mutauro we BRCA2. Izvi zvinoitika pa chromosome 13 uye zvinogona kupiwa nhaka kubva kuna amai kana baba. Munhu wose anotakura maviri emagetsi aya, uye kuchinja kune imwe chete kunopa ngozi.
Izvi zvinoshandiswa pakuchinja kwemajeni zvakagara nhaka muzvinyorwa zvinotaridzika zvinoreva kuti kana mubereki anotakura geni uye kuchinja, vana vavo vane 50 muzana yekana yekuva nekuchinja. Sezvataurwa pamusoro apa, kuva neBARCA2 kutendeuka hakuiti kuti tive nekenza, asi kunowedzera ngozi.
The BRCA2 Gene Mutation uye Lung Cancer
Iko kune sangano pakati pe BRCA2 yegene mutation uye mutanho wemapapu. Mune chidzidzo chakabudiswa muna 2014, vaongorori vakatarisa vanhu vanopfuura 11 000 vane kenza yemapapu uye vakazvienzanisa nevanhu vanopfuura 15 000 vasina kenza yemapapu. Vakaona kuti vanosvuta avo vakatakura mutauro wakasiyana-siyana weBCACA vakange vaine kaviri kacho kuti vawane kenza yemapapu sevanoputa vasina kuchinja.
Izvi zvinorevei kune nhamba? Vanhu vanosvuta vanowanikwa makumi mana makumi mana ekuwedzera kuva nekenza yemapapu kune avo vasingasvuti. Vakasvuta vanotakura mutambo vanenge makumi masere makumi matanhatu kana makumi matatu ezvimwe zvirwere zvekuwedzera chirwere chacho.
Kurondedzera izvi mune imwe nzira: kazhinji, 13 kusvika ku15 kubva muzana yevanhu vanoputa vanotarisirwa kuva nekenza yemapapu, asi kune vanoputa vanove vakanaka kune BRCA2 inoshanduka mutemo, ngozi yavo yehupenyu inenge 25 muzana. Nokuda kwekusamboputa, mukana wekuva nekenza yepamapapu kune avo vane maonero eBBRCA2 mutenhe mutenhe inorondedzerwa muchidzidzo chacho zvishoma kudarika maviri muzana.
BRCA2 kuchinja kwemajeni kunonyanya kushamwaridzana nemukenza wekemamente wemapapu , chimiro chesati duku chekenza yemapapu emapapu.
Mamwe maKenza anobatana neBrCA2 Mutations
Mimwe mimwe mishonga yekenza inobatanidzwa neHRCA2 mutations. Izvi zvinosanganisira:
- Chirwere chemukadzi wechifu - Kune vakadzi vane mutsauko we BRCA2, 45 muzana ichakura nekenza yemazamu nemakore makumi manomwe
- Kenza yemukomana yemazamu
- Kenza yeOvarian - 11 kusvika ku17 muzana yevakadzi vane mutsauko uyu ichava nekenza yevarivha (kazhinji 1.4 muzana yevakadzi)
- Kenza yepancreatic
- Fallopian tube cancer
- Melanoma
- Peritoneal kansa
- Chirwere cheprostate
- Laryngeal kansa
Unogona Sei Kuziva Kana Iwe Uchitakura Kuchinja?
Parizvino, vanhu vazhinji vanotakura mutauro we BRCA2 havazivi zvachose. Kuva nemhuri yekenza yemucheche, kunyanya kana yakaitika munhengo dzakawanda kana mudiki, inowedzera mukana.
Kuchinja kwacho kwakawanikwa kunowanzoonekwa mune mamwe madzinza aisanganisira vaJudha veAshkenazi nevanhu veNorway, Dutch, uye Icelandic.
Ramangwana
Mune ramangwana, zvinodhaka zvinogona kuwanika kune vanhu vane kenza yemapapu vachichengetedza shanduko iyi. Kunyange zvazvo vasina kuedzwa nemukenza wemapapu, mishonga inozivikanwa sePARP inhibitor yakave ichibudirira mumakirini emakirini anobatanidza vanhu vane kenza yemazamu uye kenza yevarivha neBCA2 mutations.
Tora Points Home
- Zvakakosha kuyeuka kuti kusarudzwa hakureve kuti uchawana kenza. Kuchengetedza mararamiro akanaka, kudya zvakanaka uye kudzidzira kungaderedza ngozi yako.
- Tora mhuri yakanaka yezvokurapa uye urudzira vamwe vemhuri kuti vaite saizvozvo. Izvi zvinogona kuratidzira kusarudzwa kwekenza pamwe nezvimwe zvirwere zvakadai sehosha yemwoyo. Zvichienderana nehupenyu hwemhuri yako chiremba wako angasarudza kukucherechedza iwe zvakanyanya kana panguva yekare yemamiriro aya. Ramba uchiyeuka kuti mamwe mamiriro ezvinhu aiva nemazita akasiyana munguva dzakapfuura, somuenzaniso, "kudonha" kwekudzivirira kunobatanidza mwoyo kusakundikana.
- Kana iwe utsi, siya, kana usina BRCA2 mutenuko wezvemuviri.
- Kune vanhu vari pangozi yakakura, taurai nachiremba wenyu nezvekusarudza kwekenza yemapapu kuongorora .
> Sources
National Cancer Institute. BRCA1 uye BRCA2: Ngozi yeKenza uye Kuongorora kweGenetic. Updated 04/01/15.
National Library yeMishonga. Genetics Home Reference. BRCA2. Yakabudiswa 11/09/15.
Wang, Y. et al. Zvimwe zvakasiyana-siyana zvekukura kukuru BRCA2 ne CHEK2 inobata njodzi yemukenza wemapapu. Nature Genetics . Yakabudiswa paIndaneti 01 June 2014.