Angioimmunoblastic T-cell lymphoma (AITL) rudzi rwusingawanzoiti rweHodgkin lymphoma (NHL ) . Iyo inobva kuT-seli , iyo ndiyo iyo yeropa rega rega iro rinofanira kuchengetedza muviri kubva kune utachiona. Inogona kunge yakafuridzirwa ATCL uye yaimbova angioimmunoblastic lymphadenopathy.
Chii chinonzi Angioimmunoblastic?
Izwi rokuti 'angio' rinoreva mitsipa yeropa.
Iyi lymphoma ine zvimwe zvinhu zvisingawanzoti kusanganisira kuwedzera kwenhamba yemidziyo isina kuchena yeropa mumativi emuviri anokanganisa. 'Immunoblast' izwi rinoshandiswa kureva immune immune cell (kana lymph cell). Iko masero ayo anowanzokura mumarayirasi, asi imwe nhamba yavo inowanzogara mumapfupa emasese, akagadzirira kupararira apo mamwe lymphocytes anodiwa. Kana pane zvavanowedzera muhupenyu hwavo husina kuchena uye vasingakure, vanorwara nekenza. Muchinera T-masero muAITL chirwere ndeye immunoblasts.
Ndiani Anobatsira?
Angioimmunoblastic T-cell lymphoma inongogadzira anenge 1% yevose vasina Hodgkin lymphoma. Inobata vanhu vakwegura, vane makore akaenzana vane makore makumi matanhatu. Icho chinowanzowanzoonekwa kune varume kupfuura vakadzi.
Zviratidzo
MuAITL, pane zviratidzo zvinowanzoitwa lymphoma izvo zvinosanganisira kuwedzerwa kwemakirini anonzi lymph nodes (kazhinji ainzwa mumutsipa, mazamu, uye kugomera), uyewo fivhiri, kuora kwekurema, kana husiku hunoputika.
Mukuwedzera, angioimmunoblastic T-cell lymphoma ine zviratidzo zvisingawanzoiti. Idzi dzinosanganisira maronda echando, kurwadziwa pamwe chete, uye rimwe ropa risina kunaka. Zviratidzo izvi zvakabatana kune izvo zvinonzi maitiro ekuzvidzivirira mumuviri mumuviri, inogadziriswa nemamwe mapuroteni asina kukodzera anokonzerwa nekenza masero. Kazhinji zvirwere zvinowanikwa nokuti chirwere chinowedzera simba rekudzivirira muviri.
Iyi lymphoma inewo nzira inotyisa kupfuura dzimwe dzakawanda dzisiri dzeHodgkin's lymphomas. Kubatanidzwa kwechiropa, chirwere, uye maronho inowanikwa. B-zviratidzo zvinowanikwawo kakawanda. Izvi zvinoratidzika, zvinosuruvarisa, zvinogona kuratidzira mamiriro mashoma mushure mekurapa.
Kuongororwa uye Miedzo
Kungofanana nedzimwe mishonga, kuongororwa kweAITL kunobva kune lymph node biopsy . Pashure pekuongororwa, mimwe miedzo inofanirwa kuitwa kuti ione kuti yakareba sei lymphoma yakapararira. Izvi zvinosanganisira CT scan kana PET scan , test bone marrow uye kuwedzerwa ropa.
Kana paine peputi peganda, biopsy inogona kutorwa kubva paganda kuti iwane zvimwe zvikamu zvinobatsira kuziva chirwere ichi.
Kurapa
Mushonga wokutanga mune lymphoma iyi inowanzotarisirwa kuzvirwere zvekudzivirira zvirwere-kukurumidza, kurwadziwa pamwe chete, uye kushaya ropa. Steroid uye dzimwe nhengo dzakawanda dzakawanikwa dzichibatsira mukuderedza zviratidzo izvi.
Kamwe kuongororwa kunosimbiswa uye kutsvakurudza kwakaitwa kwakagadzirwa, chemotherapy inotanga. CHOP ndiyo inowanzoitwa chemotherapy regimen yakashandiswa. Zvisinei, chirwere chinodzoka zvakare chinowanzoitika uye chinogona kuitika mukati memwedzi yekutanga chirwere chekutanga. Kuwedzera kurapwa kweiyo lymphoma kwakaoma.
Nzira dzakasiyana-siyana dzakaedzwa, kusanganisira bone marrow kana stem cell transplants. Zvirwere zvinowedzera zvirwere zvakaramba zvichiri kuipa kudarika zvimwe zvinowanzoonekwa zvepamusoro-grade lymphoma.
Sources:
Kanzira: Mazano uye Maitiro eOnology 7th Edition. Vakuru: VT DeVita, S Hellman uye SA Rosenberg. Yakabudiswa naLippincott Williams naWilkins, 2005.
Therapy in Peripheral T / NK Neoplasms. Munyori JP Greer. Yakabudiswa mumagazini yeHematology muna 2006.
Munhu Mukuru Ari-Hodgkin Lymphoma Treatment-yevashandi vehutano (PDQ®) National Cancer Institute. Yakapedzerwa naJanuary 15, 2016.