Angiotensin-kuchinja enzyme (ACE) inhibitors ndiyo yekutanga yekudzivirirwa mukurapa kukanganisa mwoyo kusakadza (CHF), mamiriro ekutyisa upenyu umo mwoyo usingaputi ropa rakakwana kune nhengo.
Maitiro Avanoita
Yakashandiswa kubudirira kwemakore anopfuura makumi maviri, ACE inhibitors inononoka kufambira mberi kweCFU nenzira nhatu:
- Vanodzivirira enzyme inotakura midzi yeropa, iyo inoderedza kushanda kweropa uye inopa ropa rakawanda kumwoyo, zvichiita kuti rive nyore.
- Vanoderedza muwandu wemunyu nemvura mumuviri, izvo zvinowedzerawo kuderedza ropa.
- Dzinodzivirira kubudiswa kwezvinhu zvinonzi angiotensin, izvo zvinoita kuti midziyo iwedzere uye inomutsa kukonzerwa kweropa.
Aina
ACE inhibitors, yakadai seVasotec ( enalapril ) uye Capoten (captopril), inonyanya kurongerwa kuti mwoyo kusakundikana kuderedza mikana yekurwisa mwoyo uye kurohwa.
Kwemakore, kushandiswa kwakasiyana kwerapi yepiritsi - pairing ACE inhibitors ne angiotensin II receptor blockers (ARBs) - ndiyo nzira yakasarudzwa. Asi nyaya ya2007 muAmerican Diabetes Association yeDOC News yakaratidza kuti vakadzi, kunyanya, vanobatsirwa zvikuru neAARB. Zvadaro, ruzivo rwakazara muna 2008 muNew England Journal of Medicine rwakatsigira kubudirira kweACE inhibitors, neAARB yakasarudzwa pane vamwe.
Migumisiro Yechirwere uye Kubatana Kwezvinodhaka
Pakutanga, varwere vanogona kuudzwa kuti vatore mishonga panguva yekurara kuti vaderedze chirwere chekutanga chekuita zvichibva pakuderedza ropa.
Zvimwe zvikamu zvinowanzoitika zvinosanganisira:
- Kuramba, kuoma kuoma
- Kushaya simba, chizuru
- Kushungurudzika mudumbu, kusava nenzara
- Ganda rinoputika
- Metallic taste in the mouth
- High potassium mazinga
- Nausea uye musoro
Kazhinji Migumisiro Yakawanda
Kazhinji migumisiro inosanganisira kusatya, fever, chills, kuora kwemaziso uye kushungurudzika mudumbu.
Taurira chiremba wako kana iwe ukawana chimwe cheizvi, asi usarega kutora mishonga iwe pachako. ARB dzakadai seCozaar (losartan) inogona kurongerwa kune varwere vane maitiro akaoma kuACE inhibitors.
Vakadzi vane pamuviri kana kunwisa, kana avo vanoronga kuva nepamuviri, havafaniri kutora ACE inhibitors. Uyezve, kana iwe une chirwere cheshuga , lupus, kana mwoyo, impempa kana chirwere chechiropa, kana kuti iwe wakanga uine chirwere chemoyo chinenge chichangobva kuitika kana kuti kuwedzerwa kwetsvo, chiremba wako angasadi kuisa ACE inhibitors.
Kubatanidza ACE inhibitors uye doro kunogona kukonzera kutyisa ropa pasi. Mimwe mishonga inowedzera uye mishonga, kusanganisira diuretics (mvura mapiritsi) nemishonga ine potassium, inogonawo kuchinja chiito cheACE inhibitors. Iva nechokwadi chokuti chiremba anonyora maACE inhibitor ane rondedzero yakakwana yemishonga yako yose.
Sources:
"ACE Inhibitors: Chidimbu cheMazano." consumerreports.org. 2008. Consumers Union.
"Angiotensin-Kuchinja Enzyme (ACE) Inhibitors." texasheartinstitute.org. Jul. 2007. Texas Heart Institute.
IYEACE Trial Investigators. "Angiotensin-Converting - Enzyme Inhibition muCable Coronary Artery Disease." New England Journal of Medicine 351: 20 (2004): 2058-68.
Mutemo, Bridget Murray. "ARBs Outperform ACE Inhibitors muMadzimai Ane Mwoyo Kukundikana." DOC News 4:11 (2007): 10. American Diabetes Association.
"Mishonga Inowanzoshandiswa Kurapa Mwoyo Kukundikana." americanheart.org . 9 Jan. 2008. American Heart Association.
Scow, Dean Thomas, Ellen G. Smith, uye Allen F. Shaughnessy. "Therapy Combination With ACE Inhibitors uye Angiotensin-Receptor Blockers Mukusakundika Kwemwoyo." American Family Physician 68: 9 (2003): 1795-98. 4 Nov. 2008..
ICHITATUI Vatsva. "Telmisartan, Ramipril, kana Vaviri muVashandi paPain High for Vascular Events." New England Journal of Medicine 358: 15 (2008): 1547-59. 4 Nov. 2008.