Maitiro eLymphoma Markers Aid pakutsvaga Lymphoma pa Molecular Level
Chii chinonzi lymphoma tumor markers, kana CD markers? Sei zvakakosha uye vanoita sei mukurapa kwema-lymphomas?
Kukosha kweCD Lymphoma Markers
Kutsunga maCD pamakristini kunokosha mukusarudza kurapa kwakanakisisa kwezvirwere izvi, asi hazvina kuwanikwa nguva dzose. Ngatitarisei nhoroondo kuitira kuti tinzwisise kukosha kweizviedzo pakugadzirisa kurapa kwakanakisisa kwekenza yenyu.
Chikonzero nei Lymphoma Markers inokosha
Edza kufungidzira rudzi rumwe chete rwesero rinokwira kusvika anenge makumi matatu emhando dzakasiyana dzekenza - dzose dzine zita rimwe. Zvirwere zvemakondomu zvakasiyana zvinogona kunge zviripo mumakirini ako emakirini, sehukuru muhuropi hwako, sechirwere chemuviri wako, kana seanoshungurudza zvose pamusoro peganda rako. Haisi nyaya yechipfuva - lymphoma inowanikwa mune imwe nzvimbo idzi ingave imwe yemhando dzakawanda. Uye kusarudza kurapa kwakanakisisa kunoenderana nekuziva rudzi rwakarongeka.
Microscope Haikwanisi Kuona Majekymasi
Kunyangwe nemakumi emakumi emakore shure, izvo chiremba wezvechipatara akaona pasi pe microscope ne tsvina yakaoma ndiyo yose yatinofanira kuziva rudzi rwe lymphoma. Uye kwaiva nemapoka mashoma e-lymphoma angave akakurumbira. Zvisinei, zvaiwanzoitika kuti maitiro emhando imwechete yemarara yakasiyana nevamwe vanhu vakasiyana. Zviri pachena, takanga tisina chimwe chinhu.
Icho Chinyorwa Chiri muMiracules
Sezvo mushonga wakabva kune masero kuenda kumaamolekoro, nzira dzakagadzirirwa kutarisa mamwe maelekemu akawanikwa pamusoro pemasero.
Apo izvi zvakashandiswa kumasero e-lymphoma, zvinhu zvakatora kuchinja kunoshamisa. Zvakabva zvaitika kuti lymphomas dzakanga dzisingori zvishoma zviduku zvakasiyana, asi dzakawanda zvakaoma.
Chii chinonzi Lymphoma CD zviratidzo?
Pamusoro pe-lymphocytes, masero anoshandurwa kuva lymphomas, anorara mamwe maamolekemu akasiyana.
Idzi idzi dzainzi 'kusiyaniswa kwemasumbu' kana kuti CD markers . Sezvakangoita lymphocytes inokura kubva kumasero matsva kusvika kune masero akakura, aya mavara anochinja. Yakawanikwa kuti lymphomas yakanga yakatarisa yakafanana pasi pe microscope yakanga ine mavara akasiyana-siyana pamusoro penzvimbo yavo. Apo izvo zvakaitika, vakaita sezvirwere zvakasiyana zvachose.
Lymphoma CD Markers muKutsvaga
Nhasi, kuongororwa kwe lymphoma hakungopedzeri kunze kwekuti vaviri ve lymphoma vanocherechedza vatanga kuonekwa. Kuti uise imwe lymphoma muboka rakakodzera, immunohistochemistry inoshandiswa kuongorora idzi maelekemu pamasero ezvinyorwa zvebiopsy.
Isu iye zvino tine mishonga chaiyo inopinda ma CD molecule pamusoro pemamwe masero e-lymphoma. Iyi mishonga - inonzi monoclonal antibodies - kurwisa masero chete ane CD chaiyo.
Mumwe muenzaniso unogona kuita kuti izvi zvive nyore kunzwisisa. Ne lymphomas, inogona kuva yakaoma kana isingakwanisi kutaurira musiyano pakati pemamwe mhando dzekenza. Mamwe lymphomas ndiB cell lymphomas uye mamwe maT cell masymymmas, asi masero eB uye maT-T anogona kutarisa zvakafanana pasi pe microscope. Kunyange zvazvo vachitarisa zvakafanana, kenza inobatanidza masero aya anogona kuita zvakasiyana zvakasiyana uye inopindura zvakasiyana nemishonga yakasiyana.
CD20 chiratidzo kana antigen inowanikwa pamusoro pemasero eB asi kwete maT cell. Kuparadzanisa guru B cell lymphoma (DLBCL) - kenza yemasero eB-inogona kutarisa kufanana neaplastic yakakura cell lymphoma - kenza yeT cells - pasi pe microscope. An immunohistochemistry test, zvisinei, inogona kusimbisa kuvapo kweCD20 - iyo antigen inowanika pamasero eB kuti igone kuti kenza DLBCL uye kwete aplastic huru cell lymphoma. Anaplastic huru sero lymphoma, zvakasiyana, inogona kusiyaniswa nekuvapo kweCD30 antigen.
Lymphoma Markers muKutsvaga Kurapa uye Kuraira
Hazviregi ipapo. Zvimwe zviratidzo zvakakosha (mumwe wavo anonzi bcl-2) anogona kunyange kutaurira chiremba kuti chirwere chako chichaita sei.
Vamwewo (kufanana neCD20) inoratidzira kana mushonga unoshanda uchishanda. Mienzaniso yeCD inowanikwa mumarapirma emaronda anosanganisira monoclonal antibody Rituxan (rituximab) iyo inotarisira CD20 antigen iripo pane mamwe masero lymphoma uyewo mamwe masero emagetsi anonzi lymphocytic leukemia.
Sezvo tsvakurudzo yakawanda uye yakawanda inopinda mune izvi, maitiro matsva ari kuuya nguva dzose. Zvechokwadi, lymphoma yakapinda munguva yeiyo molecules.
Sources:
National Cancer Institute. Tumor Markers. Updated 11/04/15. http://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-markers-fact-sheet