Chimwe chezvinhu zvakasiyana-siyana zvekenza yeprostate ndeyekuteerera kwayo kubvisa testosterone . Iyi "Achilles Heel" yekenza yeprostate yakawanikwa muma1940 apo kushandurwa kwemasvini kwakaratidzwa kukonzera kukonzera kenza. Muna 1985, Lupron, mishonga inopindwa nemishonga yakaita chinhu chimwechete yakagamuchirwa neCDA.
Lupron inoshanda kuburikidza nekunyengedza mapepa kuti avhare maitiro avo e testosterone.
Kubudirira
Lupron inodzora kenza yeprotate kwemavhareji yemakore maviri kusvika matanhatu kune varume vane chirwere chemasastatic, uye kwemakore anopfuura gumi apo kurapwa kunotanga kusati kwaitika zvirwere zvinoshandiswa. Apo Lupron inomira kushanda, mamwe mahomoni akaita seCasodex kana Nilandron anogona kupa nguva pfupi, asi nguva yavo yekuita (kuchengeta PSA pasi) inowanzotora zvishoma kudarika gore.
Kakavhiringidza kwakazara muchikoro chekuti kana kutadza kuderera muzvikamu zvePSA zvinonyatsoratidza kuti kurarama kwemurwere kuchawedzerwa. Saka mazuva ano, FDA inongobvumidza chete mushonga mutsva kana mushonga wemishonga unofambisa hupenyu huri nani mukurwisana, nzvimbo yekudzora nzvimbo. Kuratidza kuponesa kuponeswa kwakaoma zvinetso kupfuura kungoratidza kuti mishonga inokonzera kuderera kwenguva pfupi mumazinga ePSA.
Zytiga (abiraterone) iyo yakadzidziswa nevarume vane chirwere chemasastatic chakanga chava kusagadzikana naLupron chakaratidza izvi mutsva-vanozvipira vane mastatic-resistant prostate kansa avo vakagamuchira abiraterone vakaratidzwa kuti vararame 33% kwenguva refu kupfuura varume vakagamuchira placebo.
Zytiga inogadzira mishonga inoshandiswa nekushandisa kushandiswa kwemazuva mashoma kuti kushora Lupron (kunotsanangurwa sekenza kukura pasinei nesero testosterone muropa) haisi chikonzero chekenza masero akadzidza kukura pasina testosterone.
Pane kudaro, Lupron kushorwa inokonzerwa nekenza yekenza yeprotate yakadzidza nzira yokugadzira testosterone yavo mukati.
Chirwere chacho chekudzivirira chinoshanda nekuvhara enzyme inokosha inopinda mukati mekenza yesero, enzyme iyo inobatanidzwa muchikamu chekugadzira testosterone. Mutsara wakagadzirwa ndewekuti kenza yemukenza yakabviswa kubva pakugadzira testosterone yayo.
Migumisiro Yechiri
Zvimwe zvinokonzerwa neZytiga zvinogona kusanganisira kuchinja mu potassium muropa, uye mune zvisingawanzoitika, chiropa chisingaiti. Zytiga inowedzerawo chiito chepillesterol mapiritsi akaita seLipitor neCrestor saka muyero wavo unoda kuderedzwa kuti uwane mari.
Kuchengetedza pasiziyamu mazinga mumutambo wakakwana Zytiga unotungamirirwa pamwe chete ne prednisone , chimiro che cortisone. Cortisone inogona kuva nemigumisiro zvakare. Iko pane dzimwe nguva inobatanidzwa nekamuti yekutsamwa uye chironda chemudumbu. Nhamba yehuga yepamusoro inogonawo kuitika kuvanhu vane chirwere cheshuga.