Izvi zvishoma-zvakasarudzirwa zvinosarudzwa uye zvinokanganisa
Vanhu vane psoriasis iye zvino vane nzira dzakasiyana-siyana dzokurapa kuti vagadzirise zviratidzo zvavo. Retinoid products, yakabva ku vitamini A, ndiyo imwe nzira inogona kusarudza. Acitretin imwe yehutano hwakadaro inowanikwa semuromo wemishonga. Kunyange iyo inoshandiswa zvishoma pane dzimwe nzira dzokurapa zve psoriasis , zvingave zvakakodzera kufungidzira vamwe vanhu.
Abnormal Skin Cells muPororiasis
Keratinocytes ndiyo mhando huru yemasero anowanika muganda rako. Muzvisikwa zveganda, aya masero anoparadzanisa uye anokura kwenguva. Mu psoriasis, aya masero echeganda akaparadzanisa uye anowedzera mune nzira isina kunaka. Iwa masero anowanikwawo kune chitubu cheganda chinokonzera kuti vazvibata nenzira dzinorwara. Ichi chikamu chechikonzero chinokonzera zviratidzo zve psoriasis.
Izvozvo Acitretin Inoshanda Sei?
Acitretin is retinoid. Izvozvo zvinoreva kuti iri mune imwechete yemakemikari yemhuri sa vitamini A (chibereko chinokosha chinowanikwa mune zvimwe zvokudya). Mishonga yemakemikari yemakemikari yakafanana neyamacitretin yave iripo yekurapa psoriasis kubva kumavambo makumi mapfumbamwe. Rokutanga retinoid yemuromo, etretinate, kubva ipapo rakatsiviwa nechimwe chigadzirwa chitsva, acitretin. MuUnited States, zita rechiito cha acitretin iSoriatane TM .
Retinoids yakafanana neacitretin pinda mu cell membranes ye keratinocytes. Ikoko vanoshandura kudhindwa kwemamwe majene akawanikwa muDNA yako.
(Izvozvo zvinoreva kuti mamwe magenzura anogona kushandiswa kuita mapuroteni kakawanda, uye mamwe majini anogona kushandiswa kudarika kakawanda.) Izvi zvinokonzera kushandiswa kwechipiri, se:
- Kupera kweganda kuputika
- Kurasika kusina kushandiswa kwesero kwekukura nekuparadzaniswa kwemasero eganda
- Deredza kuderedza kusachena kwemasero eganda
Mimwe michina yemitambo yakakosha (sezvakaitwa tazarotene ) inogona kushandiswawo kubata chirwere che psoriasis, uye inogovera zvimwe zvakafanana nemashoko retinoids.
Zvisinei, acitretin ine mikana yakawanda yemigumisiro yakanyanya kupfuura inoridho retinoids, nokuti inotorwa mukati.
Ndivanaani Vanogona Kubatsirwa naAcitretin?
Acitretin inoshandiswa kurapwa kune varwere vane muongorori kusvika kune zvakanyanya psoriasis. Izvozvo zvinowanzotsanangurwa sevanhu vane chimwe chezvinotevera:
- Psoriasis inoputira 10 muzana yeganda ravo
- Psoriasis pamusoro pepakati pediki rweganda ravo, asi ndiani ane zviratidzo zvinokanganisa, zvakadai se psoriasis yakaoma pamaoko avo kana mucheka
Vanhu vakadaro kazhinji vanoda chidimbu chemutemo chinodhaka (sezvakaita acitretin) kana chimwe chezvinhu zvitsva zvebiologic zve psoriasis. Vanhu vane vane psoriasis chete vanowanzodikanwa kurapwa nemishonga yepicheni kuti zvirwere zvavo zviitwe.
Acitretin inogonawo kunyanya kushanda kune vanhu vane mamwe marudzi e psoriasis . Izvi zvinosanganisira:
- Psoriasis inosangana nemichindwe nematombo
- Psoriasis inobata zvipikiri
- Pustular type psoriasis
- Erythrodermic psoriasis
Mishonga yakwegura yePororiasis vs. Newer Biologic Zvinodhaka
Acitretin mumwe weboka rekare remishonga yekuenzanisira kusvika zvakanyanya psoriasis. Iro mitatu inowanzoshandiswa zvinodhaka zvinowanikwa mumuromo ndeye acitretin, methotrexate , uye cyclosporine. Iyi mishonga inoshandiswa kugadziriswa kakawanda mune varwere vane muongorori kusvika kune zvakanyanya psoriasis.
Zvisinei, mumakore achangobva kupfuura, mishonga mitsva, inonzi biologics, yatowanikwa. Izvi zvinosanganisira zvinodhaka zvakadai se etanercept uye adalimumab. Pamusoro pezvose, mishonga iyi mitsva ine zvishoma zvinokonzerwa nemigumisiro yakakura kudarika mishonga yakwegura. Biologic zvinodhaka zvakare zvinowanzobudirira mukurapa psoriasis.
Kunyange zvakadaro, kune vamwe vanhu, madhiragi akare seAcitretin angangodaro ari sarudzo yakanakisisa. Imwe nyanzvi yepamusoro yemishonga yemasikirwo yakafanana neyamacitretin ndeyokuti inotorwa nemuromo. Vamwe vanhu vanogona kusarudza izvi kumishonga inonzi biologic, iyo inowanzopiwa nejojo. Uyezve, madhiragi akare seAcitretin kazhinji anodhura zvakanyanya kupfuura biologic zvinodhaka.
Ko Acitretin Inofananidzwa Sei Nemimwe Mishonga Yemitemo yeMagariro yePororiasis?
Kana ikashandiswa pachayo, acitretin inowanzosanyanya kushanda kudarika methotrexate kana cyclosporine (mamwe maviri anowanzonyorerwa mishonga yemitemo yemutemo). Zvisinei, zvinogona kunge zvakachengeteka pane imwe yemishonga iyi yekushandisa kwenguva yakareba.
Acitretin yevanhu vane psychooriasis vane immunosuppression
Rimwe boka revarwere ve psoriasis avo vanogona kunyanya kubatsirwa neacitretin vanhu avo vakaderedza zvirwere zvekuzvidzivirira. Biologic zvinodhaka nemishonga yemidzo yemitambo sematrotrexate pamwe chete inoshanda nekudzivisa zvirwere zvemuviri wemunhu. Zvisinei, kusiyana nemamwe mimwe mishonga, acitretin haina kunyanyisa kudzivirira muviri wako. Izvozvo zvinogona kuita kuti zvive zvakakodzera kune vanhu vanototambura nezvinetso zvekudzivirira muviri , sevanhu vane HIV.
Therapy The Combination With Acitretin
Acitretin dzimwe nguva inotorwa sechirwere chisina kuroorwa, asi inowanzoshanda zvakanakisisa pamwe chete nedzimwe mishonga.
- Kunyanya, acitretin inowanzobatanidzwa ne- phototherapy , imwe yehutachiona hweVB kana chirwere cheUVA ne psoralen (PUVA).
- Acitretin inogonawo kushandiswa pamwe chete nemishonga yemapuropiyo ye psoriasis.
- Kusiyana nedzimwe mishonga yemitemo yemagariro, acitretin inogonawo kutorwa pamwe nemishonga inonzi biologic.
Iwe haufaniri KUTI ushandise acitretin neimwe vitamini A-based product, nokuti izvi zvinogona kutungamirira kuhutachiona hwehutachiona.
Kusarudzwa kweAcitretin
Acitretin inowanzowanika mumapapirosi 10mg, 17.5 mg, kana 25 mg. Varoki vakawanda vanopa disi pakati pe10mg uye 25 mg pazuva, asi vamwe vanhu pane dzimwe nguva vanoda dozi yakakwirira.
Acitretin inowanzobudirira pane yakakwirira masayiti. Zvisinei, migumisiro yemigumisiro inogona kunge yakanyanya kuitika pamatanho aya. Iwe unogona kutanga nehana yakaderera uye uchienda kune imwe yepamusoro dose kana iwe zviratidzo zvisingagadzirise, uye kana iwe usina kuva nemagumisiro kubva kuchipatara.
Zvinogona kutora mwedzi mitatu kusvika kumatanhatu usati wasvika pakupindurwa kukuru pamushonga wako.
Nzira Yokutora Acitretin
- Tora acitretin nechikafu.
- Tora nhamba yako yakatarwa nehutano hwako.
- Kana iwe uchinge warasikirwa newaiti, usapinda kaviri inotevera. Pane kudaro, rambai muroti uye tora mubairo wenguva dzose pane imwe nguva inotevera yakarongwa.
Mupiki wako wekuchengetedza utano achakuudza iwe kuti chii chairo chakakodzera kwauri.
Kubata Dambudziko
Acitretin hazviiti HERE mishonga yakachengeteka yevakadzi vane pamuviri kuti vatore. Acitretin inogona kukonzera kukanganisa kwakasiyana-siyana kwekuberekwa, kusanganisira iyo inokonzera mutezo wemwoyo, chirwere chekutya, kunzwa uye maonero, uye masimba emadzimai. Dambudziko guru kune vakadzi vanotora acitretin pakati pevhiki yechitatu uye yechitanhatu yekuzvitora kwavo. Izvi zviri pamberi pevakadzi vazhinji vanoziva kuti vane pamuviri.
Acitretin haina kukanganiswa zvachose nemuviri kusvikira kumakore matatu mushure mokumira mishonga. Nemhaka yeizvi, acitretin haafaniri kushandiswa neipi yeiyi inotevera:
- Vakadzi vane pamuviri
- Vakadzi vari kuronga kuti vave nepamuviri panguva yekurapa kana mukati memakore matatu mushure mekurapa kurapwa
- Vakadzi venguva yekubereka vasingakwanisi kushandisa chiremera chekuberekwa kwechokwadi panguva yerapi uye kwemakore matatu mushure mekurapa
Izvo haifaniri kushandiswa nevakadzi vari kuyamwa.
Zvimwe Zvimwe Zvingaitwa Nevakadzi Vakabereka Zvingaitika
- Acitretin haisi iyo yakanakisisa kurapwa iwe kunze kwekuti iwe une psoriasis yakaoma iyo isingateereri kune dzimwe mishonga, kana iwe haugone kutora mamwe marapa pane chimwe chikonzero.
- Kana acitretin ndiyo nzira yakanakisisa, iwe uchada miviri miviri isina kunaka asati uchitanga acitretin, chimwe chazvo chinofanira kuitwa panguva yekuenda kwako.
- Iwe unoda mwedzi wekuzvidzivirira muedzo apo uri pamushonga.
- Iwe unoda kushandisa maitiro maviri ekudzivirira kuberekwa paunenge uchishandisa mushonga, uye kwemakore matatu mushure mokumisa mushonga.
Zvichida Zvimwe Zviito zveAititin
Acitretin inogonawo kukanganisa migumisiro yechirwere. Izvi zvinosanganisira:
- Kuchema kwemeso, mhuno, muromo, uye ganda
- Brittle nails
- Kuora bvudzi
- Kupisa ganda rekunzwa
- Muscle aches
- Nausea
- Bony kukura pamutsana
- Kuwedzera triglycerides
Zvimwe zvinogona kuitika zvinogona kuitikawo zvakare. Kazhinji, acitretin inogona kukonzera zvinetso zvakakomba zvakadai sekuvadzwa kwechiropa kana kuputika kwepascreas. Zvinenge zvose izvi zvinetso zvinoshandiswa pakurega kurapwa. Taura nekukurumidza kune mupiki wako wehutano kana uine zvinetso.
Usati Watanga Kurapa
Usati watanga acitretin therapy, iwe uchada nhoroondo yezvokurapa uye kuongorora mumuviri. Iwe unogonawo kuedza kuongororwa ropa kuitira kuti uve nechokwadi kuti uri mukana wakanaka wokurapa. Izvi zvinogona kusanganisira zvinotevera:
- Miedzo yemafuta eropa (triglycerides uye cholesterol)
- Chiropa basa test
Kuongorora paAcitretin
Nemhaka yenjodzi yemigumisiro kubva kune acitretin, mupi wehutano wehutano achada kukuongorora iwe. Mushure mokunge iwe kutanga uchitanga kurapwa, iwe ungada kuve nekuongororwa kweropa nguva dzose kuti uone chiropa chako uye mafuta ako eropa. Pashure pemavhiki akawanda pamusoro pemishonga, iwe unofanirwa kushandura kuongororo dzishoma.
Ndiani Mumwe Asingafaniri Kushandisa Acitretin?
Kuwedzera kune vakadzi vane pamuviri nevadzimai vanogona kutora pamuviri, mamwe mapoka evanhu vanofanirwawo kudzivisa acitretin. Izvi zvinosanganisira:
- Vanhu vane hyperlipidemia
- Vanhu vane shungu kana kutora chero chero chipi zvacho chibereko chevhitamini A
- Vanhu vane chirwere chepancreatitis
Uyezve, acitretin inogona kunge isiri iyo mishonga yakanakisisa kwauri kana iwe uine mamwe matambudziko ehutano, akadai:
- Tora 1 kana tape 2 chirwere cheshuga
- Chiropa chechiropa
- Chirwere chepoyo
- Zvinetso nechinwiwa doro
Shoko Rinobva
Kutarisira psoriasis yako kunogona kuva dambudziko. Nenzira yakanaka, mazuva ano, kune nzira dzakasiyana-siyana dzokurapwa kune vanhu vane modere kusvika kune zvakanyanya psoriasis. Acitretin kazhinji haisi yesarudzo yakanakisisa yevakadzi vane makore ekubereka. Asi kune vamwe vanhu, mishonga yakakura seyake acitretin inogona kuve yakanzwisisika, kunyanya kana inoshandiswa nedzimwe mishonga.
> Sources:
> Menter A, Korman NJ, Elmets CA, et al. Mirayiridzo yekuchengetedza kutungamirirwa kweporioriasis uye psoriatic arthritis: chikamu 4. Mirayiridzo yekuchengetedza vatungamiri uye kurapwa kwe psoriasis nemagariro ekugadzirisa maitiro. J Am Acad Dermatol . 2009; 61 (3): 451-85. doi: 10.1016 / j.jaad.2009.03.027.
> Soriatane Kurondedzera Mashoko . Allergan. 2017. Steifel Laboratories. 2014. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/019821s027lbl.pdf.
> Sarkar R, Chugh S, Garg VK. Acitretin mu dermatology. Indian J Dermatol Venereol Leprol. 2013; 79: 759-71. doi: 10.4103 / 0378-6323.120721.