Viagra (sildenafil citrate) nemimwe mimwe mishonga ye erectile dysfunction (ED) yakambofungidzirwa kwechimwe nguva sechikonzero chinokonzera kurasikirwa kwekunzwa, kunyange zvazvo kuwirirana kuchiri pasi pekudzidza uye hazvizivikanwe nechokwadi.
Panguva iyo Viagra yakagamuchirwa, muna 1998, US Food and Drug Administration (FDA) yakawana kuti vanhu vashanu kubva kune 25 000 vachishandisa Viagra mumakiriniki ekuedzwa kusimbisa kurasikirwa kwekunzwa .
Iyi iyi nhamba shomanana, ndicho chikonzero kunyeverwa pamusoro pekunzwa kurasika kwakanga kusiri kwakakurumbira panguva yekubvumirwa.
Zvisinei, pakupera kwe2006, FDA yakatanga kuongorora mamwe maitiro ekurasikirwa kwekunzwa kune vanhu vanotora Viagra nemamwe madhiradhi ED ayo ari chikamu che phosphodiesterase Type 5 (PDE5) inhibitor class. Dzimwe mishonga PDE5 dzinosanganisira Levitra (vardenafil) uye Cialis (tadalafil).
Kutsvaga maitiro avo akaipa-chiitiko chekubika, iyo FDA yakawana makumi makumi maviri nemaviri evanhu vanonzwa kurasikirwa kwekunzwa mukati memazuva matatu ekupedzisira kwechiremba chechiremba cheP PDE5 inhibitor. Mhando yekurasikirwa kwekunzwa ichinyanya kuiswa unilateral sensorineural kurasikirwa kwekunzwa pamwe nekusarura kana kurasikirwa kwese kwekunzwa. Dzimwe nguva tinnitus uye neyezizi zvakabatanidzwa.
Zvikamu gumi nemashanu kubva kune makumi maviri nemakumi maviri nemana (29) zvakaitika zviitiko zvakashata zvakabatana neViagra zvakananga. Muzviitiko zvishanu, kurasikirwa kunonzwika kwakangoerekana kwaitika mushure mekutanga kwechirwere cheViagra. Vanhu vepfumbamwe vakange vasina kurasikirwa kwekunzwa kwevanhu uye mumwe munhu ainge aine kurasikirwa kwekunzwa.
Vane hupfumi vevanhu 15 vakanga "vachienderera mberi" kunzwa kurasikirwa kwevanhu uye vanhu vana vakanga vaine kurasikirwa kwenguva pfupi.
Izvi zviitiko zvinorondedzerwa hazvikwanisi kushamwaridzana zvakananga ne PDE5 inhibitor nekuda kwezvinoitika kune zvimwe zvinhu, zvakadai sezera remurwere uye kushandisa mamwe mishonga. Kunyange zvakadaro, iyo FDA yakaonekwa yakanyatsotarisirwa kuti iite kuchinja mumishonga yekurapa zvinodhaka kuti iwedzere kunyanya kufunga nezvekugona kukanganiswa kwekunzwa.
Iwe unogona kutora mashoko aya kubva pawebsite ye FDA.
I-FDA inonyevera kuti kana iwe ukatanga kunzwa kunzwa kurasikirwa paunenge uri paViagra kana mishonga yakafanana, iwe unofanirwa kumira uchitora uye taura nachiremba wako. Saizvozvowo, vanachiremba vanoziva kuti varwere vavo vari kunzwa kunzwa kurasikirwa kwemashoko pavanenge vari pamishonga iyi vanofanira kuvayambira kuti varege kuitora.
Lab Studies
Zvinogona here kuratidzwa kuti Viagra zvechokwadi inokonzera kunzwa kurasikirwa muvanhu? Vamwe vatsvakurudzi vari kuedza kuziva. Vatsvakurudzo muSouth Korea vakaita chidzidzo chemhuru dzevarume dzaive mavhiki manomwe. Kwemazuva makumi mashanu mamwe maitiro akapiwa mizinga yakawanda yeViagra. Mamwe magwa haana kupiwa chero Viagra uye akashanda seboka rinodzora rekuenzanisa. Mapoka maviri aya aive nematambudziko ekunzwa vasati vadzidza uye zvakare mumazuva mashanu, 10, 15, 25, 35, 105 uye 135 zvekudzidza.
Kunzwa kwavo kwakaedzwa nenzira dzakawanda, kusanganisira audory brainstem mhinduro uye otoacoustic emissions. Nhandare yekuongorora maitiro ehutano inotarisa kuti huropi inopindura sei kurira. Otoacoustic emissions ndiwo mafungiro asina simba anobudiswa nenzeve mushure mokunge inzwa inzwi. Zvigumisiro zvakaratidza kuti mizinga yakanyanya yeViagra yakasimbisa kuvhara kwekunzwa kwekunzwa kwepfungwa dzekuongorora brainstem.
Ndiko kuti, inzwi racho raifanira kunge rakanyanyisa kukurudzira mhinduro. Mukuwedzera, kubudisa maotoacoustic kwaive kwakasiyana pakati pemakonzo makuru uye maitiro ekudzora kana kurapa kwakapiwa kwenguva yakareba.
Vatsvakurudzi vakagumisa kuti kukwirira-kwero uye kurapwa kwenguva refu kunogona kukonzera kurasikirwa kunzwa mumakonzo. Izvozvo zvinogona kuitika zvinoitika kuvanhu here? Vatsvakurudzi vakatsanangura muenzaniso wemurume ane makore 44 uyo akawedzera kurasikirwa kwekunzwa mushure mekutora Viagra pamamirigiramu 50 pazuva kwemazuva gumi nemashanu.
Kunyange zvazvo zvisina kumbobvumirwa pachena kuti Viagra nedzimwe mishonga PDE5 dzinokonzera kurasikirwa kwekunzwa mumunhu, uchapupu hwesangano hunoramba huchiuya.
Iyi kushamwaridzana inotsigirwa nekudzidza kwezvipfuwo zvakadai seyo pamusoro apa. Kusvika ikozvino, uchapupu hunowanikwa hunoti chiitiko chacho chakaderera, asi masayendisiti anopfuurira kushevedza mamwe tsvakurudzo.
Sources:
Bin Na Hong, Tae Hoo Yi, Sun Yeou Kim naTong Ho Kang, "High Dosage Sildenafil Inhu Inonzwa Kunetseka Mumuviri", Biol. Pharm. Bull., Vol. 31, 1981-1984 (2008).
Erectile dysfunction drug and sudden loss hearing. (NOTICE! Important FDA Izaziso Zvevanadiologists) Audiology Nhasi. Nov-Dec 2007 v19 i6 p53 (1).
Isa ruzivo rweViagra. Inowanikwa kuburikidza ne http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm
Postmarket zvinodhaka zvekuchengetedza zvinodhaka zvevarwere nevatapi. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124841.htm