Vamwe vanhu vane hutachiwana hutachiwana hutachiona hweHIV kune vamwe.
Ikutanga kuchinja kwemajeni yakabatana nehutachiona hweHIV yakaonekwa pakati pemakore ekuma 1990. Inozivikanwa seCCR5-Delta32 kuchinja, inoratidzika kuti inopa kusasimba kwakasimba kune utachiona hweHIV. Izvi zvipenyu zvinoshandiswa zvinowanzowanikwa mune dzimwe vanhu vomuEurope. Izvozvo zvinokwanisika nekuti zvaibatanidzwawo nekudzivisa kune dzimwe zvirwere zvakadai sechibhokisi kana Bhokoni.
Iproprotein yePk neHIV Resistance
Pakutanga kwa2009, pepa rakabudiswa richizivisa kuti imwe chimiro chetachiona chetachiona chinogonawo kupa imwe nzira yekudzivirira HIV. Iko kushanduka kunobata maitiro ekuratidzira kweproteni inozivikanwa sePk. Pk inowanikwa pamusoro pemarudzi akawanda emasero eropa. Kunyanya, inowanikwa pamasero akawanda evanhu vanotapukirwa neHIV. Ichi chidiki chiduku chakawana kuti masero ane mazinga makuru ePk akanga akaoma zvikuru kutapukisa neHIV pane masero asina Pk. Masayendisiti akadaro akabudisawo chiitiko chinoratidza kuti vanhu vane chirwere (Fabry's disease) chinoita kuti mazinga avo ePk aone kunge asingagadziri kune rumwe rudzi rweHIV.
Zvinonakidza kuti uku kusagadzikana kwemazamu kwakave nebasa rinokosha mukutsvakurudza kwemazuva ano. Mhosva yemurwere weBerlin yakabatanidza murume akapiwa mapfupa emasese emunhu kubva kune mumwe munhu ane CCR5 mutation.
Yakabatanidzwa ne antiretroviral , chirwere ichi chinoratidzika se chakabvisa utachiona kubva muhutano hwake. Utachiona hwaiita sokuti hwakanga hwakabviswa kubva muhutachiwana hwake.
Cherechedza: Chidzidzo che2009 chave chichiziviswa zvakanyanya sekuti ropa rako rinogona kukudzivirira kune HIV. Pk inzira yekuisa ropa. Zvisinei, hazviwanzoshandiswa uye haisi chikamu cheA / B / O kana Rh kuisa maitiro. Uyezve, chidzidzo ichocho mubvunzo chakatarisa kutaridzika kwe vitrosi uye kudzidza kwavo kwekare kune vanhu vaingowana kurwisa rumwe rudzi rweHIV. Saka zvakakosha kuti tisapfurikidza nemigumisiro yekudzidza. Zvinotaridzika kuti vanhu vane mararamiro anowedzera huwandu hwePk ichave yakanyanya kukurira neHIV kune vanhu vane madiki pasi ePk. Iyi ruzivo inogona kutungamirira kumarudzi matsva eHIV therapeutics. Zvisinei, kutaura kuti ropa rekudzivirira rinogona kudzivirira kurwisana neHIV rinenge risina nguva.
Sources:
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Galvani AP & Slatkin M. "Kuongorora denda nehovepuru sezvakaitika kare zvinosarudzwa neCCR5-Delta 32 kusagadzikana kweHIV zvachose." Proc Natl Acad Sci US A. 2003 Dec 9; 100 (25): 15276-9 .
Lund N et al. "Vanhu Pk histo-blood group antigen inopa kudzivirirwa kurwere hweHIV-1." Ropa. 2009 Jan 12. Epub mberi kwekunyora
Lund N et al. "Kusagadzikana kwemasero kubva kune varwere vane chirwere cheF Fabry kuti vape utachiona hweR5 hutachiwana hwehutachiona hwehutachiona." AIDS 2005; 19: 1543-6.
Symons J, Vandekerckhove L, Hütter G, Wensing AM, van Ham PM, Deeks SG, Nijhuis M. Kutenderera pamusoro peCCR5 coreceptor nokuda kwekudzoka kwehutachiona kunotsanangura kusakundikana kwekudzoka kweCXCR4-inofanirwa kutapukira kweHIV mumurwere weBerlin. Clin Infect Dis. 2014 Aug 15; 59 (4): 596-600. doi: 10.1093 / cid / ciu284.