Mutsva weSimbi Inotakurwa Kubva Mukutengesa Kakawanda
Iyo yepamusoro yehuni ndiyo mamiriro apo kune iron yakawanda mumuviri kupfuura inogona kubviswa nemuviri. Izwi remagetsi resimbi rinodhura ndiro hemochromatosis. Pane zvikonzero zviviri zvinoita kuti iron iwedzerere: 1) nhaka yehemochromatosis kana 2) kuwedzerwa ropa hemochromatosis. Hereditary hemochromatosis ndiyo mamiriro akapfuura mumhuri. Kudengesa hemochromatosis kunoitika kana munhu achida kuwedzerwa ropa rinosviba ropa (RBC).
Iron inowanikwa mukati me hemoglobin , puroteni mukati yeRBC. Basa resimbi kuti ribatsire kutakura okisijeni kumatumbu ose. Kazhinji muviri unotora simbi yakakwana kubva pane zvekudya zvako kuti urambe uine RBC michina. Kana iwe usingadyi kudya kwakakwana nesimbi, iron yako yakawanda inoderera ichiita kuti uwedzere kushaya iron anemia . Apo maRBC anosvika kumagumo ehupenyu hwavo, simbi mukati mavo inoshandiswa zvakare kushandiswa mumitauro mitsva inobudiswa.
Nei Kune RBC Yakawanda Inotengeswa Nemhaka Inonzi Iron Overload?
Simbi inowanikwa mukati mese yeRBCs muchikamu chekuwedzerwa ropa. Saka humwe hutachiona hweRBC munhu anogamuchira hunoti hutachiona (IV) kukanganiswa kwesimbi. Dambudziko nderokuti muviri hauna kukwanisa kubvisa dare iri rakawandisa. Uyezve, vanhu vane thalassemia vanowana iron yakawanda kudarika iyo inoda kubva pakudya kwavo kuwedzera dambudziko racho.
Ndiani Ari panjodzi yekudhinda midziyo yeirivha?
Chero ani anogamuchira kuwedzerwa kweRBC akawanda ari pangozi, asi vanhu vanovimba nehutachiona vari pangozi yakanyanya.
Izvi zvinosanganisira vanhu vane chirwere chinonzi sickle cell vane chirwere (kana vari pangozi yekurohwa ), beta thalassemia guru , Diamond Blackfan Anemia , aplastic anemia , uye myelodysplastic syndrome pakati pevamwe. Vanhu vane kenza vanoda ruzivo rwekuwedzerwa ropa panguva yekurapa nekemotherapy kana kuti mafuta emapfupa ekugadziriswa ariwo pangozi yekuwedzerwa ropa rinopisa.
Dr My Physician Monitor for Iron Overload?
Vanhu vanenge vachida kuwedzerwa ropa rose vanowanzoongororwa zvakanyanya nokuda kwesimbi yakawandisa. Mune varwere, simbi inorema inogona kuonekwa mushure me12 kusvika ku15 RBC kuwedzerwa. Iron inowedzera inowanzoongororwa neropa rekuongorora ropa rinonzi ferritin pakutanga. Ferritin inomiririra huwandu hwesimbi yakachengetwa mumuviri wako. Ferritin inowanzokwevedzwa purogiramu, imwe neimwe kusvika kumwedzi mitatu, kuitira kuti chiremba wako aone kuti chii chiri kutarisa (ndiko kuti, kukosha kuri kuwedzera?). Kuchengetedza, izwi remishonga inoshandiswa kubvisa iron, inowanzotangwa mushure mokunge ferritin inopfuura 1000 ng / mL. Zvinosuruvarisa, mizinga ye ferritin inokanganiswa nezvimwe zvinhu kunze kwesimbi inowedzera. Nhamba yakakwirira ye ferritin inogona kuonekwa panguva yekurwara uye kuputika.
Nemhaka yekukanganisa ne ferritin, dzimwe nzira dzekutarisa dare rinorema dzakagadzirwa. Pamberi pacho, simbi yakakura yakaongororwa nechiropa chechiropa apo chiduku chiduku chechiropa chakabviswa uye chakaongororwa chesimbi. Parizvino, vanhu vazhinji vanogona kuongororwa magnetic resonance imaging (MRI) yechiropa uye / kana mwoyo. I-MRI inogona kuverenga chiropa chesimbi yakagadzikana (LIC) yakafanana nemigumisiro yechiropa chinopesana.
Chizoro chinotanga apo LIC yakakura kudarika 3 mg pa gramu yakaoma chiropa. Saizvozvowo, MRI yemwoyo inogona kuyera huwandu hwesimbi huri mumutsipa wemwoyo.
Ndezvipi Matambudziko Anogona Kuitika Nesimbi Kuwandisa?
Pane imwe nguva nzvimbo dzose dzekuchengetedza simbi zvisingachawanikwi, simbi inogona kuchengetwa muropa, mwoyo, pancreas, uye nhengo dze endocrine (zvinowanzozivikanwa sezvipembenene). Apo dare iri kuchengetwa munzvimbo idzi, zvinokuvadza nhengo. Izvi zvinogona kuguma ne fibrosis kana kupora kwechiropa, cardiomyopathy (chirwere chepfungwa yemwoyo), chirwere cheshuga mellitus (nemhaka yesimbi mupakreas), hypothyroidism (yakadzika utachiona hwemahomoni) uye hypogonadism (zvichikonzera kuderedza libido uye kusava nesimba mune varume uye kushaya yekuenda kumwedzi mumadzimai).
Kuchengetedza zvinetso izvi zvakakomba uye zvingangodaro zvinopisa upenyu, simbi inoremerwa inobatwa nechisimba.
Kushandiswa Kwekugadziriswa Kwesimbi Kunobatwa Sei?
Iron inowedzera kubva kuwedzerwa inorapwa ne chelation therapy, mishonga inopiwa kubvisa simbi kubva mumuviri. Kune mishonga mitatu iripo.
- Deferoxamine (Desferal)
- Deferasirox (Jadenu kana Exjade)
- Deferiprone (Ferriprox)
Therapeutic phlebotomy : Kana pane imwe nguva unokwanisa kurega kuwedzerwa ropa, simbi inokwaniswa inogona kurapwa ne serial phlebotomy. Phlebotomy yakafanana neropa rekupa iyo ropa rakawanda rinobviswa mumuviri. Munharaunda dzeRBC dzakabviswa isimbi uye apo idzi dzinotsiviwa nefupa remafupa dzichashandisa yakawandisa iron yakachengetwa mumuviri wako.
> Sources:
> Schrier SL uye Bacon BR. Chirwere Chirwere cheThalassemia uye Chimwe Chinhu Chinokurudzirwa Nyika uye Iron Zvinotakura Zvirwere Zvimwe Kupfuura Hedhi Hemochromatosis. Mu: UpToDate, Post TW (Ed), UpToDate, Waltham, MA.