Myeloproliferative neoplasms (MPN), yaimboti myeloproliferative disorders, iboka rematambudziko rinoratidzira kuwedzerwa kwepurogiramu imwechete kana akawanda yeropa (masero eropa, masero matsvuku eropa, uye / kana maplatelet). Kunyangwe iwe unogona kushamwaridzana izwi neoplasm nekenza, hazvisi izvo zvakajeka.
Neoplasm inorondedzerwa sekukura kusingawanzo kwechigunwe chinokonzerwa nekuchinja uye kunogona kuiswa sebenign (isina kenza), isati-kanza, kana kenza (inokuvadza).
Paanoongororwa, myeloproliferative neoplasms yakaipa asi munguva yakawanda inogona kuchinja kuva chirwere chinouraya (kenza). Iyi njodzi yekuve nekenza nemishonga iyi inosimbisa kukosha kwekutevedza pedyo nehematologist yako.
Zvinyorwa zvemyeloproliferative neoplasms zvakashanduka zvishoma pamusoro pemakore mashomanana apfuura asi tichazoongorora zvikamu zvose pano.
Classic Myeloproliferative Neoplasms
I "classic" myeloproliferative neoplasms inosanganisira:
- Polycythemia vera (PV): PV inokonzerwa neine genetic mutation inokonzera kuwandisa kwemasero matsvuku eropa. Dzimwe nguva sero rega rega rega uye mapeletlet akawandisawo. Uku kukwirira kweropa kunowedzera dambudziko rako rekuwedzera ropa clot. Kana iwe uine chirwere chePV, une mukana muduku wokukura myelofibrosis kana kenza.
- Iko Kunokosha Thrombocythemia (ET): Ichinoshanduko chekugadzirisa mutachiona mu ET chinoguma mune kunyanya kudarika mumaplatelets. Nhamba yakawanda yeplatelet inopararira inowedzera mukana wako wekudzidzira ropa clot. Ngozi yako yekuve nekenza kana ichionekwa neE ET ishoma kwazvo. ET yakave yakasiyana pakati peMPNs sezvo iri kuongororwa kwekuregererwa. Izvozvo zvinoreva kuti chiremba wako achabata kunze kwezvimwe zvikonzero zvepamusoro platelet count ( thrombocytosis ) kusanganisira mamwe maMPN.
- Primary Myelofibrosis (PMF): Primary myelofibrosis yave ichinzi idiopathic myelofibrosis kana agnogenic myeloid metaplasia. Izvozvo zvinokonzerwa nemagetsi mu PMF zvinokonzera kupera (fibrosis) mumapfupa emapfupa. Uku kuvhara kunoita kuti zvive nyore kumapfupa ako kuti uite masero matsva eropa. Kusiyana nePV, PMF inowanzokonzera anemia (low red blood cell count). Mucherecheche weropa ropa uye countlate count zvinogona kuwedzerwa kana kuderera.
- Chronic Chronic Myeloid Leukemia (CML) : CML inogonawo kunzi chirwere chisingaperi chine myelogenous leukemia. CML inoguma kubva kune chimiro chechimiro chinonzi BCR / ABL1. Iko kushanduka kunoita kuti kuwedzererwa kweganulocytes, rudzi rwechichena cheropa. Pakutanga, iwe unogona kunge usina zviratidzo uye CML inowanzowanikwa muchiitiko chebasa rebasa.
Atypical Myeloproliferative Neoplasms
I "inypical" myeloproliferative neoplasms inosanganisira:
- Juvenile Myleomonocyic Leukemia (JMML): JMML yainzi inonzi vana CML. Icho chimiro chisingawanzo kechirwere chinokonzera mucheche uye achiri muduku. Mushonga wemapfupa unoita kuti myeloid tsvuku dzeropa dziwedzere, kunyanya imwe inonzi monocyte (monocytosis). Vana vane neurofibromatosis type I uye Noonan syndrome vari pangozi yakakura yekuwedzera JMML kupfuura vana vasina zvirwere izvi.
- Kurwara Neutrophilic Leukemia: Haisi yeutrophilic leukemia inorwara isingawanzozivikanwa nekuwedzera kwekuwedzera kweeutrophils, rudzi rwemachena masero eropa. Aya masero anokwanisa kupindira nhengo dzako uye anoita kuti kuwedzerwa kwechiropa uye spleen (hepatosplenomegaly).
- Mazuva ano Eosinophilic Leukemia / Hypereosinophilic Syndromes (HES): Mazuva ano eosinophilic leukemia uye hypereosinophilc syndromes dzinomiririra boka rematambudziko anozivikanwa nekuwedzera kweeosinophils (eosinophilia) inoguma nekukuvadza kune nhengo dzakasiyana-siyana. Imwe vanhu vakawanda veHES vanoita zvakadai semafungiro emasopolliferative (naizvozvo zita rinogara risingaperi reyukemia).
- Mast Cell Disease: Systemic (zvinoreva kumativi ose mumuviri) mast cell sefu kana mastocytosis inowedzera kuwedzera kune chikamu chemyeloproliferative neoplasms. Mast cell maswere anokonzerwa nekuwedzerwa kwepamusoro kwemasi masero, rudzi rwechichena chemuviri weropa iro rinopinda mumapfupa emapfupa, maitiro emimba, ganda, spleen uye chiropa. Izvi zvakasiyana nemastocytosis anocheka anongogadzirisa chete ganda. Mast masero anosunungura histamine zvichiita kuti zvinokonzera zvirwere zvinogadziriswa mukati memaviri.
Sources:
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Teferri A. Mifananidzo ye myeloproliferative neoplasms. Mu: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Yakasvika musi waJune 26, 2016.)
Van Eatton RA. Chipatara zviratidzo uye kuongororwa kwechirwere chinonzi myeloid leukemia. Mu: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Yakasvika musi waJune 28, 2016.)