Dronedarone (Multaq) chirwere chinopesana nemishonga chakakonzerwa nekurapa inrial fibrillation . Mukutsvaka kwavo mishonga yakachengeteka uye inobudirira yemamiriro ezvinhu aya, makambani emishonga ave nenguva yakafungidzira girasi ravo dzvene: mushonga unoshanda seammyodarone , asi usina unhu hwakasiyana. Dronedarone yakagadzirwa naSanofi (avo vanoita amiodarone) kunyanya mune tariro yekusika iyo chirairi chitsvene.
Kubudirira
Sezvo zvinodhaka zvinodhaka zvinopinda, dronedarone inonzwisisika inoshanda pakuchengetedza hutachiona hwehutachiona. Zvinosuruvarisa, izvi hazvirevi zvakanyanya. Mitezo yakawanda yemakiriniki yakaratidza kuti dronedarone inonyatsobudirira pakuchengetedza rwiyo rwemazuva ano kune vanhu vakave neutapi fibrillation.
Kunyanya, dronedarone yakaratidzwa kuva yakakosha zvikuru kupfuura placebo. Kunyange zvakadaro, 64 muzana yevarwere vakabatwa ne dronedarone vaigara vachiita zvekare paivriyriyumu panguva yegore rokutanga rekurapa. Kusiyana neizvi, 75 muzana yevarwere avo vakagamuchira placebo vaigara vaine hutachiona hweprial. Kuvandudza uku zvishoma kunenge kwakafanana neakaonekwa nehuwandu humwe hutachiona hwemishonga - zvakare, hazvisi kureva zvakanyanya.
Muchiedza chekuchipatara kuenzanisa kubudirira kwe dronedarone kuAmododarone, dronedarone yakave yakaderera kune "mubereki" wemishonga yayo. 64% yevanhu vane efriday fibrillation inobatwa ne dronedarone yaive yakagadziriswa inrial fibrillation mugore rimwe chete, ichienzaniswa ne "chete" 42% yevaya vakabatwa neamododarone.
Zvakanaka Zvakadini Dronedarone Yakarohwa?
Dronedarone inobva kune amiodarone, iyo inonyanya kushandiswa, asi yakawanda inotyisa, mishonga inopesana yakagadzirwa. Kusiyana nemaododarone, dronedarone haina maatomu eodhomu. Zvinotendwa kuti iodine mu amiodarone inobereka zvimwe zvezvinodhaka zvinotyisa zvinokonzera zvinokonzera, kunyanya utachiona hwehutachiona hunoonekwa nemishonga uye zvichida mapapu ekutyisa .
Uye sezvarinosvika, dronedarone haina kuratidza huwandu hwehuwandu hunokonzerwa nehuwandodarone. Zvisinei, chiropa chekutyisa chakataurwa ne dronedarone, uye dzimwe mamiriro ehupukisi chechipembenene ave achionekwawo. Vanhu vakave nematambudziko eropa kana mapapu paAmododarone havafaniri kupiwa dronedarone.
Zvidzidzo zvakaratidza kuti vanhu vane mwoyo wekukundikana , kana kuti avo vakasiyira zvikamu zviduku zvinokwana 35% kana pasi, zvinogona kuva nehuwandu hwekufa pakutora dronedarone. Dronedarone haifaniri kushandiswa kune vanhu vane mamiriro aya.
Imwe mimwe migumisiro ye dronedarone inoratidzika seyochero. Zvinonyanya kuzivikanwa zvinokonzerwa nemararamiro kana chirwere chemhepo, kunonoka kwemwoyo, uye kupera.
The Bottom Line
Kungofanana nemishonga yose yekurwisa, dronedarone inofanira kushandiswa nekuchenjerera. Kushandiswa kwaro kunobatsira kuti urambe uine mwoyo wakakwana rhythm kune varwere vane zvikamu zvehutachiona hwefridhi . Kana chirwere chinonzi atrial fibrillation chichidzoka panguva inotora dronedarone, mushonga unofanirwa kumira, uye nzira yakasiyana yekurapa yakagamuchirwa.
Chirwere chacho chinoshandiswa zvakanakisisa kuvanhu vaduku vane maitiro emagetsi ehutano uye avo vane utano hwakanaka.
Verenga zvakawanda pamusoro pekurapa kweutrial fibrillation .
Shoko Rinobva
Sezvo zvave zvaitika, dronedarone haisi iyo girapi tsvene. Zvechokwadi, nhau ine chirwere ndeye nyaya imwechete yakave yakanzwika kakawanda nemishonga inopesana nemasikirwo - kushamwaridzana kwekutanga, kuteverwa nekupedzisira kugumburwa. Seboka, zvinodhaka zvinodhaka zvinongoshanda zvakakwana, asi ndezvimwe zvezvinodhaka zvinodhaka mumishonga. Dzinofanira kushandiswa chete mushure mokufungisisa nokungwarira kwezvimwe zvese, uye apo zvingave zvinobatsira zviri pachena zvakanyanya kupfuura zviitiko chaiyo chaiyo.
> Sources:
> Dorian P. Clinical Pharmacology YaDronedarone: Zvinokonzerwa NeTherapy Of Atrial Fibrillation. J Cardiovasc Pharmacol Ther 2010; 15:15.
> Hohnloser SH, Crijns HJGM, van Eickels M, et al. Migumisiro ye dronedarone pamitambo yemwoyo muhutano hwemagetsi. N Engl J Med 2009; 360: 668-678.
> Connolly SJ, Camm AJ, Halperin JL, et al. Dronedarone ari pangozi yakawanda yehutachiona hutachiona. N Engl J Med 2011; DOI: 10.1056 / NEJMoa1109867.