Kuongorora kweGenetics muPestinson's disease kunogona kuita basa rinokosha pakuongororwa
Kuongorora zvirwere zveGenetic muPalinson's inogona kuita basa rinokosha pakutsvaga chirwere chacho. Masayendisiti anotarisira kuti ruzivo rwakawanikwa nejenetics ruchazopedzisira ruchidzorera kana kuti rurege kufambira mberi kwayo.
Zvitubu zvinoendeswa muDNA yedu, zvikamu zvefa zvinogadzirisa tsika dzakaparadzana kubva kumubereki kusvika kumwana. Tine nhaka inenge mabhiriyoni matatu mapeji emajini kubva kumadzimai edu nemadzibaba.
Vanoona ruvara rwemaziso edu, kuti isu takura sei uye, pane dzimwe nguva, njodzi yatinayo pakudzika dzimwe zvirwere.
Sechiremba, ndinoziva basa iro genetics inotarisa pakugadzirisa hutano hwedu. Kuwedzerwa kwesimba kuti majeni edu akasiyana zvichienderana nechirwere ichi, asi zvose zvinokonzerwa nezvakatipoteredza uye genetics zvinobatsira pakuvandudzwa kwehutano kune imwe nzvimbo.
Kuongorora kweGenestics muHurumende yaPasinson
Muhosha yaPasinson, huwandu hwematambudziko ndiyo zvatinoshevedza zvishoma nezvishoma pasina chikonzero chinozivikanwa. Aya matambudziko "asina mhuri" anoreva kuti hapana imwe nhengo yemhuri ine Parkinson. Zvisinei, vanenge 14 kubva muzana yevanhu vanobatwa nePacinson vane yekutanga-degree relative (mubereki, mukoma kana mwana kana mwana) uyo ari kurarama nechirwere ichi. Muzviitiko izvi zvemhuri, mazamu akasiyana-siyana anokonzera chirwere ichi anogona kutora nhaka mune imwe nzira yakawanda kana kuti inodarika.
Vakawanda vane hukama hwakasiyana-siyana mumarudzi akasiyana-siyana vanowanzowanikwa mumhuri dzine chetachiona chePasinson. Muenzaniso werudzi urwu rwe nhaka ndiyo genetic mutation SNCA inoguma mukugadzirwa kweprotheni inonzi alpha-synuclein. Iyi protein inogadzira miviri yeL Lewy inowanikwa muhupano hwevanhu vane Parkinson.
Zvimwe zviitiko - LRRK2, VPS35, uye EIF4G1 - zvakagara nhaka nhaka.
Kusiyana neizvi, kushanduka kwezvinhu zvakanyanya kunokonzerwa nehutano hwekusimudzira zvirwere zvePasinson zvinomiririrwa nematambudziko mukati mezera rimwechete sevana. Izvozvo zvinoshandiswa pakuchinja zvipenyu PARKIN, PINK1, uye DJ1 magenhi ndeyemienzaniso yemhando iyi yefa.
Izvi ndezvimwe zvekuchinja kunozivikanwa asi pane zvimwe zviri kuwanikwa panguva dzose. Ramba uri mupfungwa, zvisinei, kuti mazamu akawanda ane maitiro akaderera ekutaura kana kupindira izvo zvinonyanya kureva kuti nekuda kwekuti iwe une geni harirevi kuti uchawana Parkinson. Kunyange munyaya yeRRK2 mutations, iyo inowanikwa mune zvakasikwa, kuvapo kweropa hakukwanisi kukura kwechirwere.
Ndeipi Iyo Inofanirwa Kuongorora Genetic yePacinson?
Chiremba wako angaratidza kuti kana Parkinson yako ichitsvaga inosvika pazera remakore (pasi pemakore makumi mana), kana hama dzakawanda mumhuri yako nhoroondo dzakawanikwa zvakare dzakafanana, kana iwe uri pangozi yePalinson yemhuri yakatarisana newe dzinza (avo vane Ashkenazi vaJudha kana North North Africa).
Zvisinei, chii chinobatsira kuva nekuedza kunoitwa panguva ino?
Mashoko aya angave akakosha pakuronga mhuri kune vamwe vanhu kunyange zvazvo ini ndakataura kunyange kana geni iri kupfuudzwa pairi hakurevi kufanana nekukura kwechirwere. Zvisinei, mungozi, yakanyanya kudarika maitiro ekugadzirisa mararamiro uye maitiro akawandisa, pamwero kana munhu ane chikwata chekutanga chePacinson (kureva mubereki kana munin'ina) dambudziko ravo rekuwedzera chirwere chacho 4 kusvika ku9 muzana kupfuura vanhu vakawanda.
Ramba uchifunga kuti iye zvino kune munhu ari kuedzwa, hapana kuchinja mukurapwa kwechirwere chavo chePasinson chinotarisana nemagumo ekuwana. Mune ramangwana, zvisinei, kana pane zvipatara zvishoma nezvishoma kutanga kwechirwere kana kuti kuzvidzivirira kubva pakusimuka zvachose, zvino chiratidzo chevanhu avo vari pangozi chichave chakakosha.
Kuongorora kweGenestics nekutsvakurudza kwePasinson
Kunyangwe pangave pasina ruzivo rwakananga kwauri panguva ino, migumisiro yekuongorora mazita ekugadzira muviri inogona kubatsira kutsvakurudza kwePasinson nekubvumira masayendisiti kuti anzwisise zviri nani chirwere ichi uye zvinozoita zvirongwa zvitsva. Semuenzaniso, kushanduka kwegeneti inoratidzira puroteni alpha-synuclein (SNCA) inotungamirira kune imwe rudzi rwechirwere chePalinson yemhuri. Kunyange zvazvo kuchinja uku kunongoratidzira zvikamu zvishomanana zvezviitiko, ruzivo rwechigadziriro ichi rwakave nemigumisiro yakawanda. Kudzidza kwechimiro chechimiro ichi kwakaunza kuwanikwa kuti alpha-synuclein inoungana pamwechete kuti iumbe miviri yeL Lewy iyo yakagara ichiwanikwa muhupfungwa hwevanhu vose vane chirwere chePasinson kwete chete avo vane SNCA mutation. Nokudaro, rimwe ruzivo rwemajeni rakaita kuti kuve nekutsvaga kutsvaga mumunda wePilinson mukutsvakurudza.
Kuongorora kweGenetics ndechimwe sarudzo yemunhu asi chirevo chekucherechedza: chero nguva apo kuongorora mazita ekuberekwa kunoonekwa, kunyanya mune chirwere chekushaya uko kusina kuchinja kwehutano huchienderana nemararamiro ekuwana, ichange chiri chirevo changu kuti ndione genetic mazano kuti ataure nezvehupenyu Iyi zivo ichava nemwi murwere, uye nemhuri yako.
References:
Beck, James, Ph.D. "Parkinson's Insights: Kuongorora kweGenetic uye Iwe." Parkinson's Insights: Kuongorora kweGenetic uye Iwe . Parkinson's Disease Foundation (PDF), 26 Mar. 2013. Webhu. 29 Mar. 2014. http://parkinsonsdiseasefoundation.blogspot.ca/2013/03/genetic-testing-and-you.html
Farrer, Matthew, MD. "Genetics: A Foundation for Future Parkinson's Treatments." - Parkinson's Disease Foundation (PDF) . Parkinson's Disease Foundation, Winter 2012. Web. 29 Mar. 2014. http://www.pdf.org/winter12_genetics
Puschmann, Andreas. "Genetics yaPasinson." Genetics yePasinson . European Parkinson's Disease Association, nd Web. 29 Mar. 2014. http://www.epda.eu.com/en/parkinsons/life-with-parkinsons/part-3/genetics-of-parkinsons