Synthetic HDL
Sezvo munhu wose achiziva, HDL cholesterol "cholesterol yakanaka," nokuti yakakwirira HDL mazinga akabatana nehuwandu hwehutachiwana hutachiona hwehutano. HDL inokonzera cholesterol yakawandisa kubva mumatumbu uye inodzorera iyo kuchiropa chekugadzirwa. Saizvozvowo, vatsvakurudzi vakapedza makore akawanda vachiedza kukura kurapa kunowedzera huwandu hweHDL, uye nokudaro nekuwedzera nzira yekubvisa "zvakaipa" cholesterol.
Aya maitiro akave ari kunyanya kuodza mwoyo.
Imwe nzira yekutsvakurudza iyo yaimboita yakavimbiswa zvikuru iri munzvimbo yeHDL mimetics - maitiro eHDL ayo "anofanana" nemagariro eAAA, HDL lipoprotein.
- Verenga pamusoro pekulesterol uye triglycerides
Chii Chinonzi HDL Mimetics?
Kufanana neyese lipoproteins, HDL zvikamu zvinosanganisira lipids (munyaya iyi, cholesterol), uye mapuroteni chaiwo anotakura lipid kuburikidza neropa. Mapuroteni anoumba HDL lipoprotein mhuri yemapuroteni anonzi ApoA. ApoA ndiyo "chiitiko chinoshanda" cheHDL. NdiAAA inounganidza cholesterol yakawandisa kubva pamasvingo emvura uye inoitakura. Saka iyo HDL cholesterol yatinoyera neropa rekutsvaira ishoko rekutsvaira rakabviswa kubva mumuviri, uye iri kudzokera kuchiropa chekugadziriswa.
Zvinonzwisisika, saka, kana tikakwanisa kuwedzera huwandu hweAproA mapuroteni muropa redu tinogona kuwedzera cholesterol kubviswa, uye zvichida, kuderedza dambudziko rekuwedzera atherosclerosis.
HDL mimetics imishonga inoshandisa, sezvinogona nyore, mapuroteni eAAA. Izvo zviri kuitika pakugadzirwa kweHDL particles. Vakawanda vari mukurudziro, asi tsvakurudzo uye hurongwa hwekuvandudza huri kunonoka uye kumira.
Chiitiko neHDL Mimetics
Chiitiko chekliniki yekutanga ne HDL mimetic yakashumwa muna 2003.
Imwe yeHDL yakagadzirirwa inonzi ApoA-1 Milano, inoshandiswa semavhijisi mashanu emavhigiramu kwevhiki, yakaguma nekwakakura shrinkage yemapanga mune vashomanana vevarume vane coronary artery disease. (Chiyero che shrinkage chakanga chiri chiduku zvikuru, asi chaiva shrinkage, uye chaive chichiverengwa.)
ApoA-1 Milano yakawanikwa nekudzidza vanhu makumi mana kubva muguta duku reItaly vaizivikanwa kuti vararame hupenyu hune hurefu uye hutano hwakanaka, pasinei nokuti vakaderedzwa zvakaderera HDL mazinga. Vatsvakurudzi vakaona kuti vanhu ava vaiva ne "mutant" yeHDL (iyoAAA-1 Milano) iyo yakanga isina kuonekwa nekuongororwa kweropa nguva dzose, asi iyo yakaratidza kuva yakabudirira mukudzivirira chirwere chemwoyo. Vatsvakurudzi vakakwanisa kugadzira DNA mutation yakabudisa iyi HDL itsva, uye yakawedzera iyi DNA idzva kumatambudziko ebhakato re laboratory, -kugadzira "fekitari" yekugadzirwa kweAA-1 Milano.
Ichi chidzidzo chakakonzera kufara kwakanyanya pakati pevanhu vane cardiologists uye, nekuda kwemashoko ehupfumi, pakati pevanhu vose.
Asi mumakore akapfuura takanzwa zvisina maturo pamusoro peAA-1 Milano.
Pakave nemabasa akawanda kumashure, zvisinei. Kodzero dzeAka-1 Milano dzakashandura maoko kakawanda, uye makambani mazhinji emishonga anozivikanwa ari kushanda paHDL mimetics.
Asi ikozvino zvinoratidzika zvakajeka kuti nzira yekuvandudza mishonga iyi ndeyekuti, zvishoma, yakaoma uye inodhura.
Uyezve, muna 2014 wechipiri HDL mimetic (CER-001, kubva kuCerenis Therapeutics) yakaedzwa mumuedzo wekliniki unonzi CHI-SQUARED, uye yakakundikana kuratidza kubatsirwa mukuderedza mapepa akawanda.
Ndeipi iyo HDL Mimetics Yakamira Iye zvino?
Kufarira kwakanyanyisa kubva muna 2003. Mishonga iyi yakaratidza kuva yakaoma kwazvo kukura nekugadzira, uye zvichibva pamigumisiro yeCI-SQUARED haisati yashandiswa kuva yakabudirira. Nepo isu tisingakwanisi kuziva chokwadi, zvinoratidzika semakambani makuru ezvinodhaka ave avatsigira kubva kwavari.
Vari kuumbwa nemakambani mashoma ane zvishoma.
Mukuwedzera, kuongororwa kwevatsvakurudzi vekuwedzera HDL maitiro senzira yekudzivisa chirwere chemwoyo zvakaderera zvikuru mumakore achangopfuura, nekukundikana kunoshamisa kweCETP inhibitors sejaspetrapib, uye munguva ichangopfuura, niacin. Makambani emishonga akashandisa mabhiriyoni achiedza kuwana zvinodhaka izvo zvose zvinowedzera hutachiwana hweHDL uye kuderedza chirwere chemwoyo, kusingaiti. Vanokakavadzana vanototanga kubvunza zvose "HDL hypothesis," kureva, iyo yakakwirira yeH HDL inogara yakanaka.
- Verenga pamusoro pe "rutivi rwenyama" yeeklesterol yakanaka.
Saka kuumba HDL kuchiri pasi pekugadziridzwa uye kunogona kuitika kuva chinhu chikuru chekurapa. Asi kune basa rakawanda rinoda kuitwa. Uye kunyange kana kuedza uku kuchibuda, rudzi urwu rwemishonga inoda kugoverwa (pazvino-kusvika-kutarirwa maitiro uye nguva) mukati; uye kupa makore ekuedza uye mari yakashandiswa, tinogona kutarisira kuti mishonga iyi ive yakadhura yakawandisa. Saka hatifaniri kubatisisa mweya yedu.
Pasi Pasi
Nzira yakanakisisa yokuwedzera maHDL mazinga ndeyokushandisa mararamiro akanaka. Iyi nzira inobatsira kuderedza dambudziko redu pasinei nemafungiro edu chaiwo eHCDL.
- Verenga kuti ungawedzera sei maHDL mazinga.
- Verenga pamusoro pekuongorora dambudziko rako rechirwere chemoyo.
- Verenga nzira yekuderedza nengozi yakakwirira yepfungwa.
Sources:
Tardif JC, Ballantyne CM, Barter P, et al. Migumisiro yepamusoro-density lipoprotein mimetic mujenya CER-001 pane coronary atherosclerosis muvarwere vane acon coronary syndromes: muedzo we randomusiki. European Heart Journal. 29 Mbudzi 2014 DOI: http://dx.doi.org/10.1093/eurheartj/ehu171
Nissen SE, Tsunoda T, Tuzcu EM, et al. Migumisiro yeAAA-I Milano recombinant pamakoronary atherosclerosis kune varwere vane acon coronary syndromes. JAMA 2003; 290: 2292.