Matambudziko emwoyo anosiyana pakati peCelebrex, Vioxx, uye NSAID dzakakura.
Ichi chinyorwa chikamu cheArthritis Archives.
Mharidzo chinyorwa: Pana 09/30/2004, Merck muiti weVixx, akabudiswa munyika yose, achidzikisa kutengesa kwechirwere. Musi we 04/07/2005, Zvichitsvakurudza zvekirasi yeArthritis zvinodzwa zvinonzi NSAIDs uye COX-2 inhibitors, FDA yakaronga zvirongwa zvekutonga zvakarongwa.
Dateline: May 29, 2004
Chikamu cheCanada Chiratidzira Celebrex Inogona Kuzviratidza Mishonga Inopesana Nezvokuvhiringidza Kwevanhu Vakwegura
Vanhu vane zviratidzo zveArthritis vanowanzotaurirwa chimwe chezvinhu zvisina kusarudzwa, zvinonzi antisteroidal anti-inflammatory drugs (NSAIDs) kana imwe yeboka idzva reNSAIDS rinonzi cyclo-oxygenase-2 inhibitors ( COX-2 selective inhibitors ).
Nzira dzisingasarudze NSAIDs dzakabatanidzwa nehuwandu hwekuwedzera kwekushaya mwoyo mwoyo kusakundikana. Chinyorwa chinozivikanwa kana chakagadziriswa nezvemwoyo yemigumisiro ye COX-2 selective inhibitors.
Lancet (2004; 363: 1751-56) yakaratidza migumisiro yekuongorora kweCanada inosanganisira vanhu vanopfuura 130 000 vakwegura. Muhammadi Mamdani anobva kuInstitute for Clinical Evaluative Sciences, Toronto, Canada, uye avo vaaishanda navo vakadzorerazve kugadziriswa kwehutano hwekugamuchira chipatara kwekushaya kwemoyo kumativi ose:
- 14 500 vanhu vachishandisa COX-2 inhibitor Vioxx (rofecoxib)
- 19 000 vanhu vachishandisa COX-2 inhibitor Celebrex (celecoxib)
- 5 400 vanhu vanoshandisa NSAID dzisingasarudze
- 100 000 vanhu vasingashandisi chero NSAID vakashanda seboka rinodzora
Zvidzidzo Zvidzidzo
Kuenzaniswa neboka rinodzora revasati vasiri NSAID, mhinduro dzaiva:
- Vanhu vari kushandisa Vioxx vaiva ne80% yakawanda yakawanda yekugamuchira chipatara kwekusagadzikana kwepfungwa kwemoyo.
- Vanhu vanoshandisa NSAID dzisina kusarudzwa vaiva ne40% yakawanda yakawanda yekupindirwa kwe congestive heart failure.
- Vanhu vari kushandisa Celebrex vaiva nechiyero chakafanana chokugamuchira chipatara nekuda kwekukundikana kwemoyo sevanhu vasina kumboshandisa NSAIDs.
Kusiyana pakati pekusasarudzwa kweNSAIDS uye munhu mumwechete COX-2 inhibitor maererano nekugamuchirwa kwekusagadzikana kwepfungwa kwemoyo kunogona kuratidzika kuratidza kudikanwa kwemashure makuru, anoromized, akadzingwa kuti aite kuti awedzere kudzidza.
Related Resources
- Celebrex (Celecoxib)
- Vioxx (Rofecoxib)
- COX-2 Selective Inhibitors
- Zvimwe Pamusoro peNSAIDs
- Arthritis Mishonga
Chinobva: COX-2 Inhibitor Inogona Kuve Yakachengetedzwa Mishonga Inopesana Nezvokuvhiringidza Kwevanhu Vakwegura, Lancet Issue 29 May 2004
Kutanga kubudiswa: 05/29/2004