Dzidza zvakawanda nezvePaenibacillus yemhando yeV VT 400
Muzhizha ra2016, pamusangano wegore negore weAmerican Society for Microbiology, masayendisiti akaungana kuti agovana uye anokurukura zviwanikwa zvine chokuita nenyika yebhakitiriya uye hutano hwevanhu.
Pakati pezvakawanikwa, boka rinorondedzera yose ye genome, kana kuti yakakwana yejeni, kuti bhakiteriya inonzi Paenibacillus yemhando inokwira VT 400 (PVT400). Aya mabhakitiriya aimbove awanikwa mune sali wechiremba wevana ne acute lymphoblastic leukemia (ALL).
Nhoroondo yakajeka kubva kune ino uye zvidzidzo zvedzinza ichabatsira masayendisiti kudzidza kana mabhakitiriya aya angave ane chikamu mune zvirwere zvevanhu, kunyanya kune vanhu vane chirwere chinokonzerwa neukemia chinokura pneumonia kana ropastream zvirwere.
Pneumonia muvanhu vane cancer
Chirwere chinonyanya kukonzera rufu rwekenza varwere vane neutropenia, uye kunyanya avo vane acute leukemia. Neutropenia ishoma kuverenga kweeutrophils muropa-neutrophils masero masero eropa anokosha mukubatsira muviri kurwisa utachiona .
Pasi pamapfupa ekufuridzira zvirwere zvakajairika pakati pevarwere vanorwara nekenza, pamwe nemamwe mitsara inoratidza kuti 13 kusvika ku31 muzana yevanokonzerwa neukemia vanowana chemotherapy uye kusvika 80 muzana ye hematopoietic stem cell transplant vanogamuchira vachawana kamwe chiitiko chepineumonia.
Neutropenic pneumonia inogona kuuraya zvirwere. Mumamiriro ezvinhu akadaro, vanachiremba vanotanga kurapwa kwemishonga inorwisa mabhakitiriya pakarepo, vasina kumirira maitiro e laboratory kuti vasimbise uye vatsanangure rudzi rwehutachiona hwehutachiona-nokuti zvinokosha kutanga kutanga kurapwa panguva imwechete, kuderedza dambudziko iro murwere achakurirwa nehutachiona.
Zvechokwadi, kurapwa kwekudzivirira kunoshandiswa mune mamwe mamiriro ezvinhu, izvo zvinowanikwa pasi apa.
Kufambira mberi kwekuita kwekutonga kweeutropenic pneumonia kunoita kuti tive netariro yemigumisiro iri nani. Mapoka ezvehutano akawanda anopa mazano ekuvandudzwa kwemishonga inorwisa mabhakitiriya ekufungidzirwa neutropenic pneumonia.
Uye zvinogoneka kuti vashandi vatsva vanokurudzira mhinduro dzemuviri kune utachiona zvinogona kuwedzeredza basa remishonga inorwisa mabhakitiriya.
Kuisa pfungwa pazvirwere zvepachigoni mune varwere vane neutropenia
Mirayiridzo inobva kuAmerican Society of Clinical Oncology (ASCO) inokurudzira kuti vanachiremba vanoedza kudzivirira hutachiona muzvipatara zvakanyanya neutropenia asi pasina fevri. Antibacterial and antitifungal treatment inorayirwa kana neutrophils inotarisirwa kuramba iri pasi pe100 / μL kwemazuva anopfuura manomwe. Nhungamiro inotaura kuti iyo yakagadzirirwa mushandi we antibacterial therapy preventive therapy is oral fluoroquinolone, asi iyo iyo intifungal therapy inoratidzira triazole.
Varwere vane neutropenia vanogona kuve nekusiyana kwakasiyana-siyana kwezvirwere zvishoma kupfuura vamwe vavo. Zvinogona kubatsira madaktari kuti vaone kuti mabhakitiriya anobva kupi mukufanotaura kuti ma antibiotic angangodaro anoramba sei, uye naizvozvo maitiro anowanzove akabudirira zvikuru.
Paenibacillus Species
Pachine mugumo iwoyo, masayendisiti ave achidzidza PVT400, mabhakitiriya matsva akaparadzaniswa nemurwere weukweukemia, nhengo yePaenibacillus yega-mhuri yebhakitiriya yakasiyana-siyana. Zvisikwa zvakasiyana mukati meboka iri zvave zvakasarudzwa kubva kune ivhu, mvura, miti, mukaka, uye dzimwe nzvimbo.
Zvisinei, Paenibacillus marudzi akanga asingazivikanwi achikonzera zvirwere zvevanhu. ... kusvikira zvataurwa munguva pfupi yapfuura zvakaratidza kuti zvinogona kuitika pakubatanidzwa kwetatu dzakasiyana siyana dzePenibacillus mumarudzi ezvirwere zvevanhu.
Mushure mokunge PVT 400 yakasarudzwa kubva pamateko emubhedha wevana ne acute lymphoblastic leukemia , zvidzidzo zvekutanga zvakaratidza kufanana kwezvizvi zvisikwa neamylolyticus, iyo inowanikwa mumvura inonzi larval hindgut yendiro; zvisinei, kusvika panguva ino, zvichiri chokwadi kuti P. amylolyticus haina kuonekwa kuvanhu, uye zvimwe zvidzidzo zvakaratidza kusawirirana pakati pematambudziko-VT 400 akawanikwa mune chirwere chekenza uye mamwe P.
amylolyticus strains.
Saka, apo vatsvakurudzi vakadzidza iyo yose VT 400 genome, pane dzakawanda zvitsva zvinonakidza. Yaiva nemagenzura ekudzivirira kushandiswa kwekemikirini yemishonga, sa tunicamycin uye bleomycin. Vakawanawo maitiro emabhakitiriya emapumps anokonzerwa nemishonga yekurwisa mishonga, uyewo mazita ejeni anokonzera kudzivirira maantibioti, kusanganisira vancomycin, fosmidomycin, tetracycline uye penicillin-semishonga, kana beta-lactam.
Vanyori veii genome-study vakaona kuti mahedheni akazara eGenenibacillus sp. dambudziko VT 400 richabatsira kubvisa basa rePaenibacillus mhando dzezvirwere zvevanhu uye anopa maonero muhutano hwebhakitiriya anowanzogara mune varwere vane kenza yeropa.
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