Kutsvakurudza Kunokurudzira Icho Chirwere Chekuzvidzivirira
Vogt-Koyanagi-Harada syndrome (VKH) chirwere chinonzi neurological, ziso, nzeve, uye zviratidzo zveganda. Kutsvakurudza kunoratidza kuti inogona kunge yakakonzerwa nekugadzirisa mafungiro emunhu umo muviri unorwisa masero awo ane utano ane pigment melanin. VKH syndrome haina kupfupisa upenyu kwenguva refu, asi ziso risingaperi uye ganda rinogona kuitika.
Hazvizivikanwe kuti sei Vogt-Koyanagi-Harada syndrome inowanikwa munyika yose.
Inowanzoitika kakawanda kuvanhu veAsia, Native America, Latin America, kana Middle Middle heritage. Nyaya dzakadhindwa dzeVKH syndrome dzinoratidza kuti dzinowanzoitika kakawanda muvakadzi uye kupfuura varume, uye zviratidzo zvayo zvinotanga chero panguva ipi zvayo.
Zviratidzo
Pamberi pehutano hweVogt-Koyanagi-Harada hunotanga, vanhu vanowanzoona zviratidzo zvakadai semusoro, vertigo, kushungurudzika, mutsipa wakaoma, kurutsa , uye pasi-grade fever kwemazuva mazhinji. Zviratidzo izvi hazvisi zvakananga kuVKH syndrome uye zvinogona kuonekwa sehutachiona hwehutachiwana kana fukenza . Chinosiyanisa VKH syndrome kubva "kurwara" ndiko kutanga kwezviratidzo zveziso zvakadai sechimbichimbi chisingaoneki, kurwadziwa, uye kunzwisisa kune chiedza. Kazhinji, VKH syndrome ine zvikamu zvitatu: a meningoencephalitis phase, an ophthalmic-auditory phase, uye chikwata che convalescent.
Mune meningoencephalitis phase , zviratidzo zvakadai sehutachiona husina simba, kuora musoro, kurasikirwa kwemasumbu kushanda kune rumwe rutivi rwemuviri (hemiparesis kana hemiplegia), marwadzo akabatana (dysarthria), uye kunetseka kutaura kana kunzwisisa mutauro (aphasia) kunoitika.
Muchikamu che ophthalmic-auditory , zviratidzo zvakadai sekusaona, kusuruvara, uye kushungurudzwa kweziso nemhaka yekuputika kwe iris (iridocyclitis) uye uvea (uveitis) inoitika. Zvinyorwa zvekuongorora zvinogona kusanganisira kunetseka kunzwa, kurira munzeve (tinnitus), kana chizuru.
Muchikamu che convalescent , zviratidzo zvehumbani zvakadai sechiedza kana chichena chemucheka mutsvuku, mashizha, kana eyelashes (poliosis), chiedza kana chichena chemucheka (vitiligo), uye kurasikirwa kwebvudzi (alopecia) kuonekwa.
Zviratidzo zveganda zvinowanzotanga mavhiki mashoma kana mwedzi mushure mekuona uye zviratidzo zvekunzwa zvinotanga.
Kuziva
Nokuti chirwere cheVogt-Koyanagi-Harada chisingawanzoitiki, chirwere chakakodzera chinowanzodikanwa kubvunzurudza nevadzidzisi. Icho hachisi kuedza kwakajeka kwechirwere, saka kuongororwa kunobva pane zviratidzo zviripo pamwe nemigumisiro yekuedza. Mushonga wezveuroyoyoti achaita kuti pave nechikwata chekutsvaga kuti aongorore cerebrospinal fluid (CSF) yekuchinja maitiro eVKH syndrome. An ophthalmologist achaita kuongororwa kwemaziso kutarisa uveitis. Dermatologist inotora mucheche weganda (biopsy) mwedzi mumwe mushure mekunge zviratidzo zveziso zvinotanga kutarisa kuchinja maitiro eVKH syndrome, zvakadai sokushayikwa kwe pigment (melanin) muchiedza kana machena machena echando aripo.
IAmerican Uveitis Society inokurudzira kuti zvitatu zvezvi 4 zvinotarisirwa kusangana kuti zvive nechokwadi chekuongororwa kweVogt-Koyanagi-Harada syndrome:
- iridocyclitis mumaziso maviri, uye uveitis
- zviratidzo zvehutano kana hutano hunochinja mu CSF
- zviratidzo zveganda zve poliosis, vitiligo, kana alopecia
Kurapa
Kuti kuderedza kutuka mumaziso, corticosteroids yakadai se prednisone inopiwa. Kana izvi zvisingashande zvakanaka, zvirwere zvinoshandiswa mumasikirwo akadai semazatioprin (Imuran) kana cyclophosphamide (Cytoxan, Neosar) inogona kushandiswa.
Zviratidzo zveganda zvinorapwa nenzira iyo vitiligo inorapwa, iyo inogona kusanganisira phototherapy, corticosteroids, kana mafuta anonhuwira.
Kutanga kuongororwa uye kurapwa kwechirwere cheVogt-Koyanagi-Harada kunobatsira kudzivirira zviratidzo zvekusingaperi zvakadai se glaucoma uye cataract. Kushandurwa kweganda kunogona kuva nekusingaperi, kunyange nekurapa, asi kunzwa kunowanzodzorerwa kuvanhu vakawanda.
> Sources:
Choczaj-Kukula, A. (2005). Vogt-Koyanagi-Harada syndrome. eMedicine, yakawanikwa pa http://www.emedicine.com/derm/topic739.htm
Verenga, RW (2003). American Uveitis Society: Vogt-Koyanagi-Harada Disease.