Tissue plasminogen activator, inowanzozivikanwa se TPA, inopa ropa rine simba rinoshandiswa pakurwara kushungurudzika kunorwadza. Yakagamuchirwa makore makumi maviri apfuura pakurapa kwekurohwa, yakatanga kuonekwa semashure mekushanduka uye kune ngozi. Iye zvino, makumi maviri emakore gare gare, kurapwa kwepachirwere kwakaenderera mberi zvakanyanya , asi TPA ichiri chiitiko chinoshamisa zvikuru chinowanikwa mukuchengetedzwa kwevarwere varwere.
Dambudziko rekurohwa kwemaitiro iri nani zvikuru mazuva ano kupfuura zvaivapo kusati kwashandiswa TPA nokuda kwekurohwa. Kana iwe kana munhu waunoda aine hurambudziko TPA nokuda kwekurohwa, unogona kudzidza zvakawanda pamusoro payo pano.
Chii chinonzi TPA uye nei chinoshandiswa kuti zvirokwe?
Tissue plasminogen activator inyanzvi ine simba inogona kudzivirira kuwedzera ropa rekuvhara kubva pakukura. Inoraswa nehutachiona hwehutachiona (IV) hwekukuvara kwechirwere chekukurumidzira.
Kurohwa kunokonzerwa nokuvhiringidzwa kwekuyerera kweropa kana nekuda kweropa rinonzi ( ischemic stroke ) kana kuti ropa ( chirwere chinopisa simba ) muuropi. TPA inongoshandiswa chete nokuda kwekurohwa kunokonzerwa neropa, izvo zvinonzi ischemic stroke.
Apo TPA inorohwa mumupfupa, inokurumidza kuenda kuburikidza neropa kusvika kune imwe yeropa rakavhara, iyo inoshanda kuburikidza nekudzivirira kuwedzera kwekuvhara ropa kubva pakuvhara ropa kuyerera muuropi. Izvi zvinobvumira uropi kuti hurambe huri hutano husati hwaitika kukuvara kwekurwadziwa kunogona kuitika.
Unogona Kubvunza TPA?
TPA inofanirwa kutarisirwa mukati maawa mashomanana apfuura mushure mekunge chirwere chinotanga. Kutanga kwesitiroko kunonzi kubva panguva yawakatanga kuona zviratidzo zvekurohwa . Pashure pehwindo iri pfupi chaizvo maawa mashomanana mushure mekunge chirwere ichibata, haugoni kugamuchira TPA nokuti zvinogona kukonzera kukuvadza kupfuura kunaka panguva iyoyo.
Nguva zhinji, varwere havabvunzi TPA. Asi vashandi vekurapa vanokurumidzirwa vanodzidziswa kuti vaone sitiroko uye zvivako zvekukurumidzira zvakagadzirirwa nevashandi uye zvigadziro zvekutungamirira TPA apo zvakakodzera.
Iko TPA Inobatsira Kurwisa?
Mumakore makumi maviri adarika, varwere vakawanda vave ne TPA. Iyo nguva yakareba uye kwenguva pfupi migumisiro ye TPA yakanyatsoongororwa. Pasi pose, mumamiriro ezvinhu akanaka, TPA yakaratidza kuti inobatsira.
Kuenzanisa kwemazuva ano kwevarwere vakagamuchira TPA kuti varohwe varwere vasina kugamuchira TPA vakaratidza kuti boka revarwere vakabatwa neTPA vakave neruzivo rwakanaka rwemuviri, ruzivo rwakanakisisa rwekuziva, uye huri nani hwekuchengetedza huwandu kupfuura varwere vakaroora vasina kuwana chirwere che TPA.
Vanokurumidza kurwadza varwere vanowana TPA, zviri nani kupora. Kwemaminitsi gumi nemashanu ekuputira varwere vanowana kurapwa kweTPA nokukurumidza, vakapona vasimba vanove nani zviri nani. Zvechokwadi, ichangobva kuitwa kuvandudzwa kwehutano yenyika inotarirwa kuderedza nguva yekumirira kwekutungamirirwa kwe TPA kwakagadzirisa kuponeswa kwevarwere nekuderedza zvinetso zve TPA kurapwa.
Ndezvipi Zvinetso zve TPA?
Nokuti TPA inopa simba rakasimba, iyo huru yechirungu inokonzera ropa.
Kusveta kunorwadza kwakakomba kunogona kukonzera chirwere chinopisa, izvo zvinowanzonyanya kuoma kupfuura chirwere cheschemic.
Uyezve, TPA inogona kukonzera kubuda kwemudumbu, kubuda mumimba, kubuda mumvura kana kubuda ropa remaronda kana kushandiswa kwekuvhiya. Nokuda kwezvikonzero izvi, vamwe varwere havakwanisi kubhadhara TPA.
TPA yakakurumidza kuita uye kushanda kwayo hakuiti kwenguva refu. Kana iwe wakagamuchira TPA uye usina kumbova nemigumisiro kana matambudziko mukati memazuva mashomanana ekutanga, haufaniri kuve nehanya nekunonoka kana kuti kwenguva yakareba migumisiro inobva TPA panguva yekudzoka kana shure kwekuenda kwako kumba.
TPA
TPA inokosha kurapwa kwechirwere chinogona kuchengetedza hupenyu hwako. Zvisinei, inogona kuva nengozi uye kwete wese munhu ari mukana wakachengeteka we TPA. Uyewo, kana nguva yakamanikana yakapera nenguva yaunosvika kuchipatara, haugoni kuwana chirwere che TPA nokuti chinongobatsira chete kana chichipiwa mukati maawa mashomanana mushure mekunge chirwere chakatanga.
Sources:
Kuchengetedzwa kweprombolysis inopinza mukati memamiriro ezvinhu chaiwo, Tsivgoulis G, Safouris A, Alexandrov AV, Mazano eUnyanzvi pamusoro peKushandiswa Kwemishonga, April 2015
A-control control study of the effectiveness of tissue plasminogen activator pamakirini emwedzi-vatachiona - zviitiko zvinoratidzwa uye kushandiswa kweutano, Lang CE, Bland MD, Cheng N, Corbetta M, Lee JM, Journal of Stroke uye Cerebrovascular Disease: mukuru bhuku reNational Stroke Association, November-December 2014
Nguva yekurapwa nehutachiona hwema plasminogen activator nemigumisiro yakabva kune inonzi ischemic stroke, Saver JL, Fonarow GC, Smith EE, Reeves MJ, Grau-Sepulveda MV, Pan W, Olson DM, Hernandez AF, Peterson ED, Schwamm LH, JAMA, June 2013
Mushonga-ku-sindano nguva yehutachiva plasminogen activator ekutungamirira uye zvipatara zvinokonzerwa nechirwere cheschemic inotangira uye shure kwekuvandudzwa kwehutano, Fonhaow GC, Zhao X, Smith EE, Saver JL, Reeves MJ, Bhatt DL, Xian Y, Hernandez AF, Peterson ED 2 , Schwamm LH, JAMA, April 2014