R-CHOP ndiro zita rakafuridzirwa rekubatanidzwa kwezvinodhaka zvinowanzoshandiswa sechemotherapy kune mamwe mararamiro, akadai seasiri Hodgkin lymphomas, kana NHLs . Tsamba imwe neimwe muR-CHOP inomirira mishonga yakasiyana-siyana, asi mutsara unogona kuve wakavhiringidza pakuti rimwe chete mishonga rinowanzo rine zita rinopfuura rimwe:
R = Rituximab
C = Cyclophosphamide
H = Doxorubicin Hydrochloride (Hydroxydaunomycin)
O = Vincristine Sulfate (Oncovin)
P = Prednisone
Rituximab is antibody inorwisana neCD20 antigen, puroteni iri pane yakagara isati ya B uye yakakura B lymphocytes. Rituximab inokonzera kupindurwa kwemagunha kubva kumurwere kusina CD20-positive cells.
Cyclophosphamide inozivikanwa senhengo inogadzirisa uye ine zvose zvinopesana nekenza uye anti-immune basa. Muropa, cyclophosphamide inoshandurwa kuva metabolites inosunga kuDNA, inokonzera masero kubva pakugadzira makopi eDNA, nekuita sero kufa.
Hydroxydaunomycin ishizha rakashandurwa re doxorubicin, rinozivikanwa se anti-antibiotic, uye rinopesana nekenza basa.
Oncovin kana vincristine inonamatira kune zviduku zvishoma mumasero anonzi microtubules uye inopesana nemasero emasero ekuparadzanisa.
Prednisone inhengo ye steroid ine anti-inflammatory properties, uye inoshandiswa zvakasiyana-siyana mukurapa. Mune zvimwe zvinokonzerwa nekenza masero, prednisone inogona kukurudzira chirongwa chekare chinonzi kufa.
R-CHOP inoshandiswa zvakanyanya mu-non-Hodgkin lymphoma. Inogona kushandiswa yoga, kana inogona kushandiswa pamwe nemamwe madhiragi kana kurapwa, kana kubata dzimwe mhando dzekenza pasina lymphoma. Saizvozvowo, nhengo dze R-CHOP, dzakadai sa rituximab, dzinogona kushandiswa dzoga mune dzimwe zvirwere uye kune vamwe varwere, kubatsira kubatsira kubata zvirwere.
Zvimwe pane R-CHOP
Sezvo ruzivo rwemarudzi akasiyana-siyana emymphomas ari kuwedzera, masayendisiti ari kudzidza kuti maitiro akasiyana-siyana e-lymphoma imwechete anogona kupindura nenzira yakasiyana pane regimen yakapiwa. Mishonga yemakiriniki ari kutarisa mukushandiswa kwevamwe vashandi, pamwe chete neR-CHOP, nokuda kwezvakaipa zvakasiyana-siyana.
R-CHOP inofanirwa kurapwa kwakakwana kune imwe yenzira dzakajairika dzeNHL, dzakapararira zvikuru B-cell lymphoma, kana DLBCL . Paunotarisa NHL yakazara, DLBCL inobata 25 kusvika ku35 muzana yezvose zvitsva zvinowanikwa pasi rose gore negore. R-CHOP inogonawo kushandiswa mune dzimwe nyaya dze follicular lymphoma, maererano neMitemo ye 2016 kubva ku National Comprehensive Cancer Network.
Ndezvipi kazhinji Chigadzirwa Chega Chega Chinopiwa?
Nhoroondo dzese regimen, kusanganisira uye kangani nguva imwe neimwe mishonga inopiwa, pamusoro penguva ipi yenguva, uye mune zvikamu zvakasiyana, zvinogona kusiyana zvichienderana nehuipi, mhinduro yemurwere, uye vanachiremba kana masangano anobatanidzwa.
- Imwe mitevedzeri yemishonga inonzi inotenderera, saka unogona kunzwa vanachiremba vachitaura nezve "ingani mamiriyoni eR-CHOP" anorongwa, somuenzaniso.
- Imwe protocol inosanganisira kutungamirirwa kwerituximab sekukanganiswa kwemaawa mashomanana pazuva rokutanga rekurapa, asi madhiragi ehurumende yeCOP angatangwa zuva rinotevera. Iyo yose nzira inogona kudzokororwa vhiki nhatu dzose kwemazana matanhatu kusvika ku8. Zvisinei, nhasi vanachiremba vanotaura zvakare nezve "CHOP-like regimens," uyewo, uye pane zvirevo zvakasiyana-siyana zvechiremba vanachiremba vanogona kutevera kuti vanoshandisa mishonga iyi.
Semuenzaniso wehumwe hutsika dzakasiyana-siyana paR-CHOP, chimwe chinhu chinonzi "R - mini-CHOP" chiri kuongororwa. The Groupe d'Etude des Lymphomes de l'Adulte (GELA) - boka rekutsvakurudza rine zita rechiFrench zvikuru-rakaongorora mubvunzo wokuderedza utsinye hwevanhu vane DLBCL vane makore makumi mapfumbamwe nemakumi mapfumbamwe nemakumi matanhatu kusvika kuzana makumi matatu nemaviri. Vanotarisira kuongorora kubudirira uye kuchengeteka kwekuderera Chirwere cheCOP (doxorubicin, cyclophosphamide, vincristine, uye prednisone) chemotherapy nechirwere chinowanzoitwa rituximab - iyo monoclonal antibody inobata masero ane CD20 'tag' - kune vakwegura vane DLBCL.
Kusvika ikozvino, pamakore maviri kubva, zvabuda zvave zvichikurudzira; uyewo kusimbisa kukosha kwezvimwe zviitiko zvevarwere muzera rezera iri.
Apo chirwere chemukati chemotherapy regimen, kana R- "miniCHOP," yakashandiswa, kubudirira kwakaratidzika kunge kwakangoenzana nemakore maviri kusvika kumazinga akaenzana, asi nehuwandu hwakaderedzwa hwechipatro-yakabatwa hospital hospital.
Nharaunda Dzakabatana
Vose rituximab neCOP vane migumisiro yechirwere, uye ruzere rwakakwana rwemigumisiro inogona kuitika kunze kwehuwandu hwechikamu chezvino. Heano mazita mashomanana, sarudza zvinogona kuitika, zvisinei:
- Iwe unowanzorasikirwa nevhudzi rose pamusoro wako. Mvere dziri mumashani pamwe nedzimwe nzvimbo dzinogonawo kuonda kana kubuda. Kusuruvara kwebvudzi kunowanzotanga mushure mekutanga kana yechipiri yechem chemotherapy, uye inenge nguva dzose nguva pfupi kuti bvudzi richakura zvakare pashure pokunge chemotherapy inoguma.
- Nausea uye kurutsa kana kunzwa kunzwa kurwara zvinowanzoitika uye zvinogona kuitika kubva pakarepo mushure mekurapa kwemazuva matatu mushure mekurapa.
- Kuvharwa kunogona kubuda nekuda kwevincristine pamwe nemimwe mishonga inogona kupiwa nokuda kwekutsvaira uye kurwadziwa.
- Mishonga yemuromo inogona kuonekwa imwe nguva mushure mekurapa, uye izvi zvinogona kukuita kuti uve nechirwere mumuromo mako, saka kutarisira muromo kunokosha.
- R-CHOP inogona kukukanganisa mano ako ekutora pamuviri kana baba baba mwana.
- Iwe unogona kunge uri nyore kutapukirwa panguva yechirwere che CHOP, saka edza kusabatana nevanhu vane utano kana chirwere uye kushambidza maoko ako nguva nenguva kuti ubatsire ngozi yako yekubata chirwere kana utachiona.
- R-CHOP inogona kuderedza nhamba yeplatelets iyo inobatsira ropa kuti ripfeke, saka iva nechokwadi chekuudza chiremba wako kana iwe uine kubvunda kana kubuda ropa iwe haugoni kutsanangura.
- Prednisone is steroid uye ine mikana yakawanda yemigumisiro, kusanganisira mafungiro emafungiro, kuwedzera kuwanda, uye kuzvimba.
> Sources:
> Offner F, Samoilova O, Osmanov E, et al. Frontline rituximab, cyclophosphamide, doxorubicin, uye prednisone ne bortezomib (VR-CAP) kana vincristine (R-CHOP) yevasiri GCB DLBCL. Ropa . 2015; 126 (16): 1893-1901.
> Eyre TA, Clifford R, Roberts C, et al. Simba rimwe NCRI chikamu chechipiri chekudzidza che CHOP pamwe chete neOatumumab mukugadziriswa nekuchengetedzwa kwevarwere vane Hurter's syndrome. BMC Kanzura. 2015; 15: 52.
> Bibas M, Castillo JJ. Ruzivo rwezvino pamusoro peHIV-inobatanidza Plasmablastic Lymphoma. Mediterr J Hematol Inofadza Dis. 2014; 6 (1): e2014064.