Kupararira Kanzera DNA May Aid Lymphoma Detection
Kunyanya kutsvaga-kutora sampu yemashizha anonyunyuta ekuongorora-laboratory-inowanzodiwa kuti kutanga kuongororwa kwe lymphoma. Tsanangudzo kubva kune zvinyorwa zvinoshandiswa zvinobvumira vanachirwere kuti vafunge nezvekenza yemakemikari maitiro, kana mavara ose akasiyana emakemikirini emukenza uye mapuroteni, uye kujekesa ruzivo irworwo kuti iwedzere kurapa.
Saka zvipembenene zvinopa vanachiremba ruzivo rwakakosha ruzivo rwekuongororwa uye kurapwa. Pasinei nekukosha kwavo kusinganzwisisike, biopsies haisi pangozi uye zvikanganiso.
Mukuwedzera, vanhu vakamboonekwa kuti vane lymphomas vanodawo kuti chirwere chavo "chikwirirwe" pane zvakasiyana-siyana: pakutanga, kuona kuti zvakapararira sei panguva yekugadzira; mushure mokunge, kuona kuti iri kupera mukurapa kurapwa; uye zvizhinji gare gare, pakuongorora, kuve nechokwadi kuti vanachiremba vari pamusoro pezvinhu kana kenza inodzoka shure mushure mekutanga kurapwa. Zvakare, kukosha kwekufungidzira hakukwanisiki, asi imaging ine zvigadziro zvayo zvezvipingamupinyi, zvakadai sekutsvaira kumisi. Ndicho chikonzero izvi zvinoshandiswa zvinoshandiswa zvakarongedza kuitira kuti kubatsirwa kuri kudarika njodzi dzekutsvaga.
Remangwana: Kubvisa Kubva Kubva Biopsies uye Zvikamu
Nhasi, iyo nzira yegoridhe yakagadziriswa yekupedza kenza sezvinotsanangurwa pamusoro apa. Kunyanya, computed tomography ( CT ) uye fluorodeoxyglucose (FDG) positron emission tomography (PET) kupenya kunowanzoshandiswa pakugadzira uye kuziva kuti kanhi inopindura sei kurapwa.
Kazhinji maitiro maviri aya akabatanidzwa, uye anonzi PET / CT. Kunyange zvazvo izvi zvidzidzo zvekufungidzira zvakakosha zvakakosha uye zvakagadzirisa kurapwa kwevarwere mu lymphoma, zvinosanganiswa nekusvibiswa nemirairo, mari, uye mune zvimwe zviitiko, kusava nechokwadi.
Zvose izvi zvinoita kuti vatsvakurudzi vafarire kutsvaga nzira itsva, dzakanyanyisa, dzinodhura uye dzisingasviki dzekusimudzira kenza yemunhu.
Chimwe chinangwa ndechokuti uwane zviratidzo zvakadai, sekuenzaniswa kwegene, izvo zvinogona kuyerwa chete neropa rekuongorora ropa kuti uchengetedze mabhesi pamukwereti kuitira kuti somuenzaniso iwe usatombofanira kuongororwa sezvinogara uchienzanisa munguva yemberi.
Apo kenza yemasera anofa, dzimwe dzeDNA dzavo dzinoguma muropa. DNA kubva mumasero ekenza akafa anonzi inopararira tumor DNA, kana ctDNA. Masayendisiti akagadzira miedzo kuti aone DNA inobuda. Mhando iyi yekutaurirana dzimwe nguva inonzi "mvura inoshandiswa mvura," uye vatsvakurudzo vanotaura nezvezvinobatsira zvekuongorora chirwere, uyewo kufanotaura nezvemhinduro yomunhu kune kurapwa kare.
Kuratidza Tumor DNA Study
Mukuongorora kwakabudiswa, vatsvakurudzo pa National Cancer Institute vakaongorora ropa kubva kuvanhu 126 neDLBCL nokuda kwekuvapo kwekufamba kwechirwere cheDNA. Kuparadzanisa guru-B-cell lymphoma, kana DLBCL, ndiyo inowanzosiyana yerinomma, kenza yeropa inotanga mune mamwe masero ezvirwere zvemuviri.
Pasinei nokuva nechitarisiko chakafanana pasi pemakroscope, zvikamu zvakasiyana zveDLBCL zvinogona kunge zvakasiyana. Maererano neAmerican Cancer Society, kazhinji, vanenge vatatu kubva kune vana vachange vasina zviratidzo zvehosha pashure pekurapwa kwekutanga, uye vazhinji vanorapwa nemishonga.
Kenza inowedzera kusvika kusvika ku40 muzana yevanhu, zvisinei, uye iyo inowanzorapora, kunyanya kana inodzoka kare uye / kana apo maitiro emarara masero muropa ravo akakwirira, maererano neNational Cancer Institute.
Munhu wese aripo purogiramu yemazuva ano akanga agamuchira kurapwa kweDLBCL maererano nemitemo mitatu yakasiyana, nemishonga yakadai sa etoposide, prednisone, vincristine, cyclophosphamide, uye doxorubicin, inozivikanwa seEEPOCH, kana kuti isina rituximab, mumakiriniki emakiriniki pakati paMay 1993 neDecember 2013.
Kuongororwa ropa kwakaitwa mushure memumwe wemakemikrasiro, pakupera kwekurapa, uye nguva dzose maitiro akaongororwa.
Vanhu vakateverwa kwemakore akawanda mushure mokurapa, uye CT zvikwangwani zvakaitwa panguva imwechete sekuongorora ropa. Vanhu vari muchidzidzo ichi vakateverwa kuva mumiriri wemakore gumi nemaviri mushure mekurapa-ndiko kuti, nhamba yepakati mumaketani yaiva makore gumi nemana, asi vanhu vakateverwa kwenguva pfupi uye kwenguva refu.
Ropa Rokuedzwa Rinofanotaurwa Kufambira mberi, Kudzokorora
Pakati pevanhu 107 vakange vane kuregererwa kwakakwana kwekenza, avo vakawana ctDNA inowanikwa mumarimusi eropa vakanga vanopfuura 200 kazhinji kacho kuti chirwere chavo chifambire mberi kune avo vasina kumboona DNA.
Kuongororwa ropa kwakakwanisa kufanotaura kuti vanhu vaisazopindurei kurapwa kwekutanga kwechipiri chekurwisa kenza.
Kuyera ropa kwakaitawo kuti kuonekwa kwekenza kuchidzoke zvakare pakati pemwedzi 3.4 kusati kwave nehupi hupi hwehupiki hwehutano hwehutachiona, tisati tawana kuonekwa neT CT scan.
Pari zvino, mvura inoshandiswa mumvura muDLBCL inotsvakurudza uye haisi FDA inobvumirwa kana inorayirwa nemitemo yeCNCN. Izvo ruzivo rwakapiwa nemvura yakasviba haifaniri kushandiswa kutungamirira kurapa muDLBCL.
Ramangwana Mirairo
Kune huri nemibvunzo yakawanda isina mhinduro uye zvinetso zvinosanganiswa mukuchengetedza mabheji pamatachiona achishandisa mashekeri ekuongorora ropa, asi nheyo yezivo inoramba ichikura nekuvandudza.
Munyaya ye lymphoma, uye zvikurukuru yose yakasiyana-siyana yeiyo isiri Hodgkin lymphoma , zvakasiyana-siyana zvezvipembenene izvi zvinokonzera basa rakaoma. Kunyange kana uchitarisa kuipa kwakafanana, kwakadai seDLBCL, zvinogoneka kuti rimwe chiratidzo chinogona kushanda zvakanaka mumatambudziko ose.
Pakupedzisira, tarisiro, ndeyekuti zvimwe zvezvinodiwa, nheyo, uye zviyero zvakajairika kune vanorwara nekenza vemazuva ano zvinogona kudziviswa uye zvinotsiviwa nezviedzo zvinocherechedza izvi zviratidzo uye kuyera mazinga avo mumuviri.
> Sources:
> America Cancer Society. B-cell lymphomas. Anoparadzira chikuru B-cell lymphoma.
> Melani C, Roschewski M. Mashekeri ekucherechedza masero-asingasviki anopararira dumire DNA mune zvisiri Hodgkin lymphoma. Oncology (Williston Park). 2016; 30 (8). pii: 218406.
> NIH. Kupararira DNA remuviri muropa kunogona kufanotaura kudzokorora kwechirwere chinowanzovhiringidzika che lymphoma.