Prucalopride imishonga yakagadzirirwa kubata chirwere chisingaperi - dambudziko rehutano rinoratidzwa nechigarire chisina kuoma uye chakaoma chezvigaro kwenguva refu, pamwe chete nezvimwe zviratidzo zvinoshungurudza zvakadai sechizvaro chemuviri, flatulence, uye kunyange kurutsa. Nzira dzekurapwa kwechirongwa chekugara kwenguva refu dzinosanganisira kunyanya kudya uye mararamiro ehupenyu uye / kana marashi.
Prucalopride ikozvino inowanika muEurope, pasi pezita rezita rekuti "Resolor" uye muCanada se "Resotran". IEuropean Medicines Agency (EMA) yakabvumira kushandiswa kwe prucalopride (Resolor) chete yekurapa kusagadzikana kwenguva refu kuvakadzi vasina kugamuchira kushandiswa kwemarara . Zvidzidzo zviri kuitwa kuitira kuwana mvumo kuburikidza neEEM nokuda kwekushandisa prucalopride mune varume vanotambura nekugara kwenguva refu.
Prucalopride Inoshanda Sei?
Prucalopride inonzi se 5-HT4 agonist. Izvi zvinoreva kuti inobatsira ma-5-HT4 receptors nokuda kweeurotransmitter serotonin. Izvi zvinofungidzirwa kuti kuwedzere motility yemudumbu maitiro nekuwedzera peristalsis, kana kubuda kwemisumbu yematumbo inokonzera chigaro kubva mumuviri, zvichiita kuti zvibato zvive zviri nyore kupfuura uye zvichiita kuti pave nekufamba kwenguva kakawanda.
Prucalopride ndeyeboka rimwechete remishonga seZelnorm.
Zvisinei, prucalopride yakagadzirirwa kuva nechiito chakasiyana pamuviri kuitira kuti kuderedzwa mikana yevasingawanzo asi yakaoma zviratidzo zvepfungwa zvinokonzera Zelnorm kubudiswa pamusika.
Inobatsira Sei Prucalopride pakubata Chronic Constipation?
Muchiedza chemakiriniki kusvika zuva, prucalopride yakaratidzwa kuva yakakwirira pane placebo munzvimbo dzinotevera:
- Kuwedzerwa kuwanda kwemafambiro edzimba uye akazara.
- Kuvandudza kunzwisisa kwehutano hwehupenyu hwehupenyu.
- Kuguma mune murwere kuona kuti kuvimbiswa hakusi kwechinetso.
Chii Chiri Nhengo Dzakashata dzePrucalopride?
Mukutsvaga kusvika panguva ino, zvinotevera migumisiro yakave yakaitika:
Pane Prucalopide Kubatsira IBS?
Mukutsvaga kwekutsvaga kwekutsvakurudza, American College of Gastroenterology inopedzisa kuti tsvakurudzo inotsigira kubudirira kwe prucalopride kune zvose zvisingaperi kusagadzikana uye IBS-C. VaAcG vatsvakurudzo vanocherechedza kuti prucolopride haina kutakura ngozi yeZelnorm yezviitiko zvakakomba zvepfungwa.
Ndiani Asingafaniri Kutora Prucalopide?
Vamwe vanhu vari pangozi yakakwirira yokuva nemigumisiro yakaipa kana kuti zvinetso kubva pakutora prucalopride. Izvi zvinosanganisira vanhu:
- Anozivikanwa hypersensitivity kumushonga wezvinodhaka kana chimwe chezvigadzirwa zvayo
- Renal kuora mwoyo kunoda dialysis
- Utumbo hunokonzera kana kuvhara
- Kubvumira ileus
- Mamiriro ekutuka ane simba emukati wemukati
- Zvirwere zvakakomba uye zvisingagadziki zvakagadzikana zvinokonzera, kunyanya arhythmias kana ischemic cardiovascular disease.
Sources:
Ford, A., etal. " American College of Gastroenterology Monograph paKutonga kweIriritable Bowel Syndrome uye Chronic Idiopathic Constipation " American Journal of Gastroenterology 2014 109: S2-S26.
Ford, A. & Suares, N. "Migumisiro yemazimbe uye mapirisa emishonga muhutachiona hwemazuva ano: kuongorora nekuongorora meta" Gut 2011 60: 209-218.
Maneerattanaporn, M., Chang, L., & Chey, W. "Emerging Pharmacological Therapees for the Irritable Bowel Syndrome" Gastroenterology Mishonga yeNorth America 2011 40: 22-243.
"Movetis anotanga chikamu chechitatu kuchipatara chirwere ne prucalopride muvarume vane varwere vane chiremera chisingaperi" Movetis NV Press Release September 24, 2010.
"Resolor" European Medicines Agency Yakasvika musi waMarch 17, 2011.
Quigley, E. "Prucalopride: kuchengetedzwa, kubudirira uye zvingave zvishandiswa Kurapa Kwokuwedzera muGastroenterology 2012 5: 23-30.