Nodular sclerosing Hodgkin lymphoma, kenza yemarikisi masero, ndiyo chirwere cheHodgkin chirwere. Iyo ndiyo inowanzozivikanwa yeHodgkin lymphoma munyika dzakabudirira, inotora makumi matanhatu kusvika ku80 muzana yevanhu vose vanorwara nechirwere ichi.
Nodular sclerosing Hodgkin lymphoma inokanganisa zvikuru vechidiki uye vechidiki. Icho chinowanzoitawo zvishoma pane vasikana kupfuura vakomana.
Zita rokuti 'nodular sclerosing' rinotorwa kubva pakuonekwa kwemuviri wecymph node pasi pe microscope mune rudzi urwu rweHodgkin lymphoma.
Zvimwe zviratidzo zve nodular sclerosing Hodgkin lymphoma yakawedzerwa lymph nodes mumutsipa, mumakumbo kana mukati mebhokisi . Kuongororwa kwe lymphoma kunoitwa ne lymph node biopsy.
Vanhu vakawanda vanoongororwa muzvikamu zvekutanga uye vanogona kurapwa nemishonga inosanganisira chemotherapy uye remishonga inonzi radiation.
Imwe yeZviverengeka dzakasiyana Hodgkin Lymphomas
Mazita ose e-lymphoma marudzi uye subtypes anovhiringidza kunyange kune vanachiremba vasingatauri navo nguva dzose. Hodgkin chirwere uye Hodgkin lymphoma zvinoreva chinhu chimwe chete, asi, kune marudzi akasiyana-siyana e-lymphoma, ayo Hodgkin ari imwe chete. Uye kune marudzi akasiyana-siyana eHodgkin lymphoma, zvakare. Saka, hezvino mhanho-pasi ye nodular sclerosing Hodgkin lymphoma maererano neinopindirana mumufananidzo mukuru we lymphomas yose:
Izvo zvikamu zviviri zvinokosha zve lymphoma ndeyeHodgkin uye Kwete-Hodgkin lymphoma.
Hodgkin lymphoma inogona kuwedzera kuputsika mumapoka maviri:
- Classic Hodgkin lymphoma - iyo ine mazita akawanda
- Nodular lymphocyte-predominant Hodgkin lymphoma
"Nodular lymphocyte predominant" uye "nodular sclerosing" haisi chinhu chimwechete - iyo inotaura nezvemhando mbiri dzakasiyana dzeHodgkin lymphoma.
Nodular Sclerosing Hodgkin lymphoma - iyo lymphoma ichiri kutsanangurwa - is subtype ya Classic Hodgkin lymphoma. Classic Hodgkin lymphoma ine mavara mana anotevera:
- Nodular sclerosing
- Mixed cellularity
- Lymphocyte-rich
- Lymphocyte-yapera.
Mhinduro: Nodular Sclerosing Classic Hodgkin Lymphoma
Nodular sclerosis Hodgkin lymphoma (NSHL) ndiyo inonyanya kufanana-mahara-based pathology-based subtype pakati pevechiri kuyaruka uye vechidiki mumatunhu akabudirira. NSHL inewo simba rakagamuchirwa nhaka, uye ine zana yakawanda inowedzera ngozi kune zvakafanana mapatya.
Munguva pfupi yapfuura, pakanga paine chidzidzo chikuru chakaitwa pachisangano chemirairo ye ultraviolet kubva zuva uye zvakasiyana-siyana zveHodgkin lymphoma. Muchidzidzo chaEmily Bowen uye vashandi pamwe navo, Hodgkin lymphoma matambudziko akanga ari akaderera mumapoka evanhu vane yakakwirira kupfuura zuva rose. Kunyange zvazvo kuwanikwa uku kwakanga kuri kuitika, chete, izvi zvaionekwa zvichiita kuti vanhu vave ne nodular sclerosis subtype.
Zvimwe zvidzidzo zvenguva ichangobva kuve zvichiongorora kuongororwa kwakasiyana-siyana, kudzivirira zvirwere zvekuzvidzivirira, uye kuti ingabatana sei nedzimwe nzira dzinozivikanwa kuti dziri kuenderera mberi mune dzimwe nzira dzeklasi yeHL.
Chidzidzo chaPetro Hollander uye vaaishanda navo vakaona kuti kudzivirira zvirwere zvekudzivirirwa kwezvirwere zvinopindira kurongwa kwakagadzirirwa rufu receptor (PD) -1 nzira ndiyo nzira itsva yekurapa pakadzokorora uye kuratidzira classical Hodgkin lymphoma.
Iboka iri rakawana kuti mamwe maitiro emasero akawanikwa kumativi ose echitsauko, uye kwete chechiremera chemasero pachavo, aibatanidzwa nekufananidzira. Chidzidzo chacho chakawana kuti migumisiro yekare yeHL yakanga yakanyanya kuipa apo aya masero machena eropa, kana kuti microenvironment masero, akanga akawandisa achiita PD-1 na PD-L1. Vakaronga kuti mapoka aya evarwere angabatsirwa nekurwisana nechemotherapy regimens uye, zvichida, kubva kuDP-1 inhibitor semutambo wokutanga.
> Sources:
> Cozen W, Li D, Best T, et al. A geneome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma inoratidza ngozi yeloci pa6p21.32. Ropa. 2012; 119 (2): 469-475.
> Hollander P, Kamper P, Ekstrom K, et al. Kukwirira kwakawanda kwePD-1 + uye PD-L1 + leukocyte mukirasi yeHodgkin lymphoma microenvironment inobatanidzwa nechepasipera. Ropa Adv. 2017; 1 (18): 1427-1439.
> Bowen EM, Pfeiffer RM, Linet MS, et al. Ukama huri pakati pehutachiona hwemazuva uye Hodgkin lymphoma subtypes muUnited States. British Journal of Cancer. 2016; 114 (7): 826-831.