Kana iwe wakamboudzwa kuti une multiple endocrine neoplasia (MEN) syndrome, iwe unoziva kuti pane zvakanyatsoongorora uye kurapwa kweiyo isiri iyo mamiriro.
The Definition of MEN
Multiple endocrine neoplasia (MEN) chirwere chekurapa chinoratidzwa nekuve nekamwe kemukari imwe nhengo dzehengo dzedocrine panguva imwe. Kune hutano hwakasiyana-siyana hwemakumbo endocrine anozivikanwa kuti aitika pamwe chete, uye imwe neimwe yemitambo iyi inorongwa seumwe wezvimwe zvakasiyana (MEN) syndromes.
Izvo zvipembenene zvinokura sechikamu chehurwere hweMENU imwe neimwe inogona kuva yakashata kana yakaipa. Utachiona hwemhondi ndeyezviremera zvisingadziviriki zvinogona kukonzera zviratidzo zvekurapa asi kukura zvishoma, hazviparadzi kune dzimwe nhengo dzomuviri uye hazvisi kuuraya. Zvimwe zvironda zvinosuruvarisa , kune rumwe rutivi, zvinokonzera kenza zvinogona kukura nokukurumidza, zvinogona kupararira kune dzimwe nhengo dzomuviri, uye zvinogona kunyange kuuraya kana dzikasara dzisingateereri.
Syndromes
Kune zvitatu zve syndromes izvo zvinoonekwa sevanhu vanowanzovhiringidzika veMEN syndromes. Chirwere chimwe nechimwe chinokonzerwa nehutano husina kuchena, izvo zvinoreva kuti chirwere ichi chinosangana mumhuri senhaka. Vane syndromes vanonzi MEN 1, MEN 2A, uye MEN 2B.
VANHU 1: Vanhu vanoonekwa kuti vane MEN 1 vane zviremara zveganda repituitary, gland parathyroid, uye pancreas. Kazhinji, matumbu aya anonhuwa, kunyange zvazvo zvisingaiti kuti zvive zvakaipa.
VANHU 1 Zviratidzo: Zviratidzo zveVANHU 1 zvinogona kutanga panguva yehuduku kana pahukuru.
Zviratidzo zvacho zvinokanganisa nokuti matumire anosanganisira nhengo dze endocrine dzinogona kuita kuti huwandu huve nemigumisiro yakawanda pamuviri. Chimwe chemakumbo chinokonzera kuchinja kusina kuenzana kwakabatana nehutoni husingaiti.
- Nhengo dzepamuviri dzinokonzera misoro , kusara kwemwedzi, kusabereka, kubudisa mukaka wemukaka, nekuwedzerwa kwemapfupa.
- Mimba inopisa inokonzera kurwadziwa kwepamu, kurutsa, chirwere, uye zvionda.
- Zvirwere zvepathyroid zvinokonzera kukwirira kwema calcium, iyo inogona kubudisa mafyvo matombo sechiratidzo chekutanga chinoonekwa.
VANHU 2A: Vanhu vane MEN 2 vane zvirwere zvehutachiona, matrenal adrenal gland, uye tumaronda yepathyroid.
VANHU 2A Zviratidzo: Zviratidzo zveMEN 2A dzinotanga mukukura; kazhinji kana munhu ari mumakore ake makumi matatu. Sezvakaita kune vamwe vEV syndromes, zviratidzo zvinokonzerwa nokushanda kwezviremera zve endocrine.
- Utachiona hwemaperembudzi kazhinji huno matamu anotanga kuonekwa muMEN 2A, uye zvinogona kuguma nekuputika kana kuti kudzvinyirira mumutsipa, uye zvinogona kuva zvakaipa.
- Adrenal gland tumors, inonzi pheochromocytoma , kunyanya inosanganisira chikamu chedrenal gland chinonzi adrenal medulla. Pheochromocytoma inogona kukonzera high blood pressure, rapid heart rate, uye sweating.
- Zvironda zvePathyroid zvinogona kukonzera kukwirira kwekasiki, uye zviratidzo zvinogona kusanganisira nyota yakawandisa uye kugara uchicheka.
VANHU 2B: Izvi ndizvo zvisingambozivikanwi zvezvipembenene zvisingawaniki uye zvinoratidzirwa nehutachiona, chirwere chinonzi adrenal gland tumor, neuromas (cysts) mumuromo uye chirwere chekudya, kusagadzikana kwemapfupa emapfupa, uye chimiro chisina kujairika uye chine simba chinotsanangurwa se marfanoid features.
VANHU 2B Zviratidzo: Zviratidzo zvinogona kutanga muhuduku, kazhinji vasati vava nemakore gumi. Chiratidzo chakajeka cheMEN 2B chimiro chakareba, chinyararire. Neuromas inoratidzika sekukura mukati uye kumativi ose mumuromo, uye vanhu vane MEN 2B vanogona kunge vane dumbu uye zvinetso zvekudya, kunze kwezviratidzo zvekenza yekenza uye pheochromocytoma.
Kuziva
Chiremba wako angave ane hanya kuti iwe unogona kuva neVANHU syndrome yakatevedzana nehutano hwemapfupa anopfuura endocrine, pamwe chete nemhuri yako nhoroondo. Iwe haufaniri kunge uine zvirume zvepachiina zveimwe yevarume veMEN syndromes kuti chiremba wako afunge nezveVANHU. Kana iwe uine kamuviri kamwe kana unhu, kana kunyange kana uine chirwere chimwe chekupedzisira chechigodhi chinosanganiswa neVANHU, ipapo chiremba wako angakuongorore kune mamwe maronda zvisati zvava zviratidzo.
Saizvozvowo, nhoroondo yemhuri haisi yekuti vanhu vatsungirire, nokuti munhu anogona kuva wekutanga mumhuri kuti ave nechirwere. Izvo zvipembenene zvinokonzera vanhu vanga vatsanangurwa, uye kuongorora mazita ega kunogona kuva sarudzo mukusimbisa kuongororwa.
Panewo kuenzana kwehutano nehutano hweVANHU wese-unogona kunge uine VANHU kunyange kana iwe usingaiti zvakakwana mune imwe yemararamiro emuviri.
Kurapa
Mushonga wevanhu vose veSEN syndromes unobva pane zvishoma zvakasiyana. Haasi munhu wose anoonekwa kuti ane MEN 1, MEN 2A, kana MEN 2B vanowana chirwere chakafanana chaihwo chirwere. Kazhinji, kurapwa kunowanikwa pane zvinangwa zvitatu, izvo zvinosanganisira kuderedza zviratidzo, kuona mutezo mangwanani, nekudzivirira migumisiro yezviremara zvakaipa.
Kana iwe uine zviratidzo zvinokonzerwa nekusava nehomoni, iwe unenge uchitsvaga kurapwa kwezviratidzo izvozvo. Zvirwere zveMedocrine zvinowanzochinja maererano nenguva, nokuti nhengo dze endocrine dzinoshanda zvichienderana nekuenzanisa kwakaoma kwezvakanaka uye zvisina kunaka mhinduro. Izvi zvinoreva kuti mahomoni anowedzera kusagadzikana angagumisa kupomesa kana kukurudzira kugadzirwa kwemamwe mahomoni mumuviri. Nokudaro, kunyange kana iwe ukagamuchira kurapwa kwehomoni kwechinguva, iwe ungada chirongwa chakasiyana kana kuchinjwa kwemuti wako munguva yemberi.
Icho chimwe chinhu chinokosha chekuita kweMENI kunosanganisa kunyatsocherechedza uye kutarisa kuziva zviratidzo zvitsva uye kuona chero kuipa kwepakutanga. Zvirwere zvinosuruvarisa zvingadikanwa kurapwa nekuvhiyiwa kana chemotherapy vasati vaita zvinetso zvehutano zvakanyanya.
Shoko Rinobva
Chero mhando ipi neipi yemaronda inogona kutyisa. Uye kuva nechirwere chinopfuura chimwe chinotyisa zvikuru. Kana iwe wakamboudzwa kuti une kana unogona kunge uine endocrine neoplasia, iwe unogona kunge unonetseka nezvekuti zviratidzo zvipi zvinogona kuitika zvakare uye kana hutano hwako huri panjodzi.
Icho chikonzero chokuti MEN syndromes inozivikanwa uye yakasarudzwa inoita kuti mamiriro ako aoneke kupfuura zvaanoita. Pasinei nokuti izvozvi hazvisi nyore syndromes, zvakarondedzerwa muhuwandu hwakanyanya uye kune nzira dzakarongeka dzekutarisira zvirwere izvi. Nepo iwe uchinyatsodikanwa nekutsvaga kurapwa mune zvekurapa, pane nzira dzinobatsira dzekutarisa mamiriro ako uye iwe unogona kunyatsogutsikana kuti nehutano hwepedyo, iwe unogona kuva nemugumisiro wakanaka.
> Kwakabva:
> Wasserman JD, Tomlinson GE, Druker H, et al. Multiple Endocrine Neoplasia uye Hyperparathyroid-Jaw Tumor Syndromes: Clinical Features, Genetics, uye Kuongororwa Mukurumbira Muhuduku. Clin Cancer Res . 2017 Jul 1; 23 (13): e123-e132.