Migumisiro inoratidza kuti chirwere ichi chinogona kuderedza chirwere cheAlzheimer
Handifariri zvinyorwa zvekunyora nezvemawere uye chirwere cheAlzheimer . Chirwere cheAlzheimer chirwere chinosuruvarisa. Inoramba ichifambira mberi. Mishonga inogamuchirwa neDAA yekurapa chirwere ichi chakafanana neAricept, Nemenda, uye Cognex hazviiti kuderedza chirwere chemakiriniki.
Nyanzvi dzakawanda dzeukama dzinoziva kuti mishonga inokosha zvikuru kune varwere vane chirwere cheAlzheimer.
Kunyange zvakadaro, vadadi vanokumbira mishonga iyi netariro yokuti iyi meds inogona kubatsira mune imwe nzira duku. Pakupedzisira, kurapa kwakanakisisa kwevaya vane chirwere cheAlzheimer ishungu yekuchengetedza iyo isingori kuchengetedza hutano hwakanaka hwehupenyu kune munhu ane chirwere asiwo mararamiro ehupenyu kune muchengeti pachake.
Pasinei nekukanganisa kwangu kwakanyanya kunyora nyaya pamusoro pehosha yeAlzheimer, ndakabvumirana neni kuti ndivhare chirwere chete kana imwe chirwere chechirwere chechirwere ichi chichiratidza kuderedza kusagadzikana kwekuziva kune avo vane chirwere. Munguva pfupi yapfuura, migumisiro yepakutanga kubva kumisungo inosanganisira biogen's aducanumab inoratidza kuti iyi antioclonal antibody inogona kudzivisa kufambira mberi kwekliniki yeAlzheimer's disease.
Chirwere cheAlzheimer ndiyo inonyanyozivikanwa yehutano hwemwoyo. MuUnited States, inofungidzirwa mamiriyoni mashanu eAmerica ane makore makumi matanhatu nemashanu apfuura anogara nechirwere ichi. Chikamu chechirwere cheAlzheimer chinonoka uye hachikwanisiki.
Nokufamba kwenguva, kuchema kweAlzheimer erodes, kufunga, uye kufunga. Pakupedzisira, munhu ane chirwere chinotyisa ichi asiya asingakwanisi kuita kunyange mabasa akajeka uye mabasa ehupenyu hwezuva nezuva.
Tsanangudzo yedu yezvino yehutachiona hwechirwere cheAlzheimer inogumira kune "amyloid hypothesis ." Kunyanya, neurodegeneration inokonzerwa nehomwe ye amyloid-beta (Aß) peptides muuropi-tissue plaques.
Kuunganidza Aß kunokonzera Alzheimer's disease pathogenesis. Chimwe chinhu chinokonzera chinosanganisira neurofibrillary tangles yakaitwa tau protein. Kusanzwisisana pakati peAß kuburitsa uye Aß kusununguka kunotungamirira pakuumbwa kwemashoko aya.
Kusvika iye zvino, mhuka yezvirwere zvakasiyana-siyana yakagadzirirwa kurwisana nechirwere cheAlzheimer nekutsvaga amyloid. Kunyanya, iyo anti-aducanumab inoshanda nekukonzera Fc-receptor-mediated phagocytosis yeAß plaques. Mune mamwe mazwi, aducanumab inokurudzira mapegocyte emuviri wedu kuti tipe Aß.
Mumakore achangobva kupfuura, "amyloid hypothesis" yakabvunzurudzwa zvakanyanya uye yakanyorwa neyanzvi dzakawanda sekudzvinyirirwa. Tisati tine kliniki yekugadzirisa kwehana, uye vazhinji vanodavira kuti kuunganidza kweAß kunogona kuva chikamu chekutakura kukuru uye kusinganzwisisiki kunokonzera neurodegeneration. Kunyanya kunyanya, mune avo vane chirwere cheAlzheimer, Aß inotanga kukanganisa kusagadzikana kwegore kusvika makore gumi kusvika kune gumi nekudaro kuvhara chirevo chechikonzero chinongonzwisisika-uye-effect. Uyezve, kushandiswa kwemasabolism ye-amyloid precursor protein (APP) kunoguma kwete Aß chete asiwo zvimwe zvikamu zvinogona kuita basa muAlzheimer's pathogenesis.
Kubva pamigumisiro yepakati pePekutanga 1b kuongororwa kwechipatara kweAducanumab inonzi PRIME, Biogen yakazvipira kuChirwere chechitatu chechipatara chechirwere.
Heano mamwe emigumisiro yemazuva ano:
- Kurapa neAducanumab kwakaguma nokuderedza kwemajoka emamyloid kune vanhu vane chirwere chinonzi prodromal kana chidiki cheAlzheimer's disease.
- Kuderedza muzvikwangwani kwakaratidzwa nenzira yekufungidzira kwePET, uye kuderedzwa uku kwaiva mubairo- uye nguva-inotarisirwa.
- Mushure megore rimwe rekurapa, vatori vechikamu vane chirwere chekutanga cheAlzheimer vakaratidza kuora mwoyo kunononoka mukusaziva kwepfungwa sezvakaonekwa ne Mini-Mental Status Examination (MMSE) uye Cognitive Dementia Rating.
- Kuchengetedzwa uye kushivirira kushivirira kweAducanumab kwakagamuchirwa. Mimwe migumisiro yakaipa yaisanganisira misoro uye ARIA (maitiro akasiyana-siyana emifananidzo yeamyloid).
Nekuda kwechirwere cheAlzheimer kana chero ipi zvayo mishonga mitsva inobvumidzwa neDFA, inofanirwa kupfuura nepamuedzo weChikamu chechitatu. Sezvakakurukurwa munyaya ino ichangobva kutaurwa inonzi "Zvimwe zviedzo zve b-secretase inhibitors muAlzheimer" kubva kuChitubu Biotechnology , vamwe vanogadzira zvinodhaka zvezvinodhaka zveAlzheimer vanomhanyira kuPeople 3 trials. Iyi tsika ine ngozi nokuti migumisiro yechipatara isingakoshi kubva muChikamu chechitatu chechitatu ichavhara kukurudzira kwechirwere. Mushure mezvose, hapana munhu anoda kuisa mu "drug" zvinodhaka.
Nemhaka yokuti chirwere chinokundikana kuratidzira zvikwereti zvikakosha mune imwe chirongwa cheChikamu 3 chekare hazvirevi kuti mushonga haushandi. Somuenzaniso, zvinogoneka kuti mishonga inogona kubudirira pamatayanisi akasiyana kune avo vakaedzwa. Kana, mamwe mishonga inoshanda zvakanaka kune vamwe vanhu. Panzvimbo yekudarika Rubicon nekuita kuChiedza chePeji 3, iri pfungwa yakanaka yekuita tsvakurudzo yechikamu chechipiri chekuedza uye kunyatsonzwisisa mushonga nemigumisiro yacho. Kusiyana neizvi, Biogen yakasarudza kuenderera mberi neChirwere chechikamu chechikamu chechikamu chechitatu muchiedza chekukurudzira zviitiko zvishoma kubva ((pasi-powered) Phase 1b miedzo.
Kana iwe kana munhu waunoda ane chirwere cheAlzheimer, tapota verenga nyaya ino mukati menyaya uye pasina tariro yechema. Biogene ichiri imwe nguva kubva pakugadzira kugamuchirwa kweAducanumab, uye isu tichiri kuda zvakawanda zvezvipatara zvinowanikwa. Kunyangwe zviitiko zvekutanga pamusoro peAducanumab zviri kuvimbisa, madhiragi eAlzheimer anozivikaniswa nekukundikana kutema musweard, uye isu tisati tatoona kurapa kwakanyatsoshanda kunobatsira kuderedza kufambira mberi kwechirwere ichi.
Sarudzo Sources
Chinyorwa chinonzi "The Amyloid Hypothesis yeAlzheimer's Disease: Kufambira Mberi uye Kupikira Pamugwagwa weTrapeutics" naJ J Hardy uye DJ Selkoe vakaparidzirwa muScience muna 2002. Vanosvika musi we3/22/2015.
Ropper AH, Samuels MA, Klein JP. Chitsauko 39. Zvirwere zvechirwere zveNerous System. Mu: Ropper AH, Samuels MA, Klein JP. eds. Adams & Victor's Principles of Neurology, 10e . New York, NY: McGraw-Hill; 2014. Yakasvika musi waMarch 22, 2015
Chinyorwa chakanzi "Zvinonyanya Kuedzwa zve ß-secretase inhibitors muAlzheimer's naCormac Sheridan yakabudiswa muChina Biotechnology muna 2015. Yakapiwa musi wa3/22/2015.